Update on rabies
Alan C JacksonDepartments of Internal Medicine (Neurology) and Medical Microbiology, University of Manitoba, Winnipeg, MB, CanadaAbstract: Human rabies is almost invariably fatal, and globally it remains an important public health problem. Our knowledge of rabies pathogenesis has been learned mainly...
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ftdoajarticles:oai:doaj.org/article:5ccfe0af89444ada9053a7b46fc0bd5a 2023-05-15T15:11:36+02:00 Update on rabies Alan C Jackson 2011-02-01T00:00:00Z https://doaj.org/article/5ccfe0af89444ada9053a7b46fc0bd5a EN eng Dove Medical Press http://www.dovepress.com/update-on-rabies-a6197 https://doaj.org/toc/1179-7282 1179-7282 https://doaj.org/article/5ccfe0af89444ada9053a7b46fc0bd5a Research and Reports in Tropical Medicine, Vol 2011, Iss default, Pp 31-43 (2011) Arctic medicine. Tropical medicine RC955-962 article 2011 ftdoajarticles 2022-12-31T00:09:57Z Alan C JacksonDepartments of Internal Medicine (Neurology) and Medical Microbiology, University of Manitoba, Winnipeg, MB, CanadaAbstract: Human rabies is almost invariably fatal, and globally it remains an important public health problem. Our knowledge of rabies pathogenesis has been learned mainly from studies performed in experimental animal models, and a number of unresolved issues remain. In contrast with the neural pathway of spread, there is still no credible evidence that hematogenous spread of rabies virus to the central nervous system plays a significant role in rabies pathogenesis. Although neuronal dysfunction has been thought to explain the neurological disease in rabies, recent evidence indicates that structural changes involving neuronal processes may explain the severe clinical disease and fatal outcome. Endemic dog rabies results in an ongoing risk to humans in many resource-limited and resource-poor countries, whereas rabies in wildlife is important in North America and Europe. In human cases in North America, transmission from bats is most common, but there is usually no history of a bat bite and there may be no history of contact with bats. Physicians may not recognize typical features of rabies in North America and Europe. Laboratory diagnostic evaluation for rabies includes rabies serology plus skin biopsy, cerebrospinal fluid, and saliva specimens for rabies virus antigen and/or RNA detection. Methods of postexposure rabies prophylaxis, including wound cleansing and administration of rabies vaccine and human rabies immune globulin, are highly effective after recognized exposure. Although there have been rare survivors of human rabies, no effective therapy is presently available. Therapeutic coma (midazolam and phenobarbital), ketamine, and antiviral therapies (known as the “Milwaukee protocol”) were given to a rabies survivor, but this therapy was likely not directly responsible for the favorable outcome. New therapeutic approaches for human rabies need to be developed. A better ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
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Directory of Open Access Journals: DOAJ Articles |
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Arctic medicine. Tropical medicine RC955-962 |
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Arctic medicine. Tropical medicine RC955-962 Alan C Jackson Update on rabies |
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Arctic medicine. Tropical medicine RC955-962 |
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Alan C JacksonDepartments of Internal Medicine (Neurology) and Medical Microbiology, University of Manitoba, Winnipeg, MB, CanadaAbstract: Human rabies is almost invariably fatal, and globally it remains an important public health problem. Our knowledge of rabies pathogenesis has been learned mainly from studies performed in experimental animal models, and a number of unresolved issues remain. In contrast with the neural pathway of spread, there is still no credible evidence that hematogenous spread of rabies virus to the central nervous system plays a significant role in rabies pathogenesis. Although neuronal dysfunction has been thought to explain the neurological disease in rabies, recent evidence indicates that structural changes involving neuronal processes may explain the severe clinical disease and fatal outcome. Endemic dog rabies results in an ongoing risk to humans in many resource-limited and resource-poor countries, whereas rabies in wildlife is important in North America and Europe. In human cases in North America, transmission from bats is most common, but there is usually no history of a bat bite and there may be no history of contact with bats. Physicians may not recognize typical features of rabies in North America and Europe. Laboratory diagnostic evaluation for rabies includes rabies serology plus skin biopsy, cerebrospinal fluid, and saliva specimens for rabies virus antigen and/or RNA detection. Methods of postexposure rabies prophylaxis, including wound cleansing and administration of rabies vaccine and human rabies immune globulin, are highly effective after recognized exposure. Although there have been rare survivors of human rabies, no effective therapy is presently available. Therapeutic coma (midazolam and phenobarbital), ketamine, and antiviral therapies (known as the “Milwaukee protocol”) were given to a rabies survivor, but this therapy was likely not directly responsible for the favorable outcome. New therapeutic approaches for human rabies need to be developed. A better ... |
format |
Article in Journal/Newspaper |
author |
Alan C Jackson |
author_facet |
Alan C Jackson |
author_sort |
Alan C Jackson |
title |
Update on rabies |
title_short |
Update on rabies |
title_full |
Update on rabies |
title_fullStr |
Update on rabies |
title_full_unstemmed |
Update on rabies |
title_sort |
update on rabies |
publisher |
Dove Medical Press |
publishDate |
2011 |
url |
https://doaj.org/article/5ccfe0af89444ada9053a7b46fc0bd5a |
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Arctic |
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Arctic |
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Arctic |
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Arctic |
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Research and Reports in Tropical Medicine, Vol 2011, Iss default, Pp 31-43 (2011) |
op_relation |
http://www.dovepress.com/update-on-rabies-a6197 https://doaj.org/toc/1179-7282 1179-7282 https://doaj.org/article/5ccfe0af89444ada9053a7b46fc0bd5a |
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