Resveratrol as an epigenetic therapy for flavivirus infection: A narrative review

• Published in: Asian Pacific Journal of Tropical Medicine
• Main Authors: Kim-Ling Chin, Kim-Kee Tan, Sazaly Abu Bakar, Nurhafiza Zainal
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wolters Kluwer Medknow Publications 2023
• Subjects: infectious diseases; epigenetic; resveratrol; flavivirus; dna methylation; histone; non-histone proteins; micro-rna; Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.4103/1995-7645.391776; https://doaj.org/article/5ccc5c1b037e48a4b0149e7edcd8d9c5

Flaviviruses are a group of positive-stranded RNA viruses that cause a broad spectrum of severe illnesses in humans worldwide. Clinical manifestations of flavivirus infections range from mild febrile illness to hemorrhage, shock, and neurological manifestations. Flavivirus infections cause a substantial global health impact, with an estimated more than 400 million cases of infections annually. Hence, an understanding of flavivirus-host interaction is urgently needed for new antiviral therapeutic strategies. In recent years, many aspects concerning epigenetic therapy for viral infections have been addressed, including methylation of the genome, acetylation/deacetylation of histone complex and microRNA regulation. In this context, we surveyed and reviewed the literature and summarized the epigenetic effects of resveratrol, a natural polyphenol with potential anti-viral properties, on flavivirus infections.