Insights into the Evolution of Longevity from the Bowhead Whale Genome
The bowhead whale (Balaena mysticetus) is estimated to live over 200 years and is possibly the longest-living mammal. These animals should possess protective molecular adaptations relevant to age-related diseases, particularly cancer. Here, we report the sequencing and comparative analysis of the bo...
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ftdoajarticles:oai:doaj.org/article:5cb71fcc599b4343858c3cc10a216423 2023-05-15T15:35:58+02:00 Insights into the Evolution of Longevity from the Bowhead Whale Genome Michael Keane Jeremy Semeiks Andrew E. Webb Yang I. Li Víctor Quesada Thomas Craig Lone Bruhn Madsen Sipko van Dam David Brawand Patrícia I. Marques Pawel Michalak Lin Kang Jong Bhak Hyung-Soon Yim Nick V. Grishin Nynne Hjort Nielsen Mads Peter Heide-Jørgensen Elias M. Oziolor Cole W. Matson George M. Church Gary W. Stuart John C. Patton J. Craig George Robert Suydam Knud Larsen Carlos López-Otín Mary J. O’Connell John W. Bickham Bo Thomsen João Pedro de Magalhães 2015-01-01T00:00:00Z https://doi.org/10.1016/j.celrep.2014.12.008 https://doaj.org/article/5cb71fcc599b4343858c3cc10a216423 EN eng Elsevier http://www.sciencedirect.com/science/article/pii/S2211124714010195 https://doaj.org/toc/2211-1247 2211-1247 doi:10.1016/j.celrep.2014.12.008 https://doaj.org/article/5cb71fcc599b4343858c3cc10a216423 Cell Reports, Vol 10, Iss 1, Pp 112-122 (2015) Biology (General) QH301-705.5 article 2015 ftdoajarticles https://doi.org/10.1016/j.celrep.2014.12.008 2022-12-31T12:08:19Z The bowhead whale (Balaena mysticetus) is estimated to live over 200 years and is possibly the longest-living mammal. These animals should possess protective molecular adaptations relevant to age-related diseases, particularly cancer. Here, we report the sequencing and comparative analysis of the bowhead whale genome and two transcriptomes from different populations. Our analysis identifies genes under positive selection and bowhead-specific mutations in genes linked to cancer and aging. In addition, we identify gene gain and loss involving genes associated with DNA repair, cell-cycle regulation, cancer, and aging. Our results expand our understanding of the evolution of mammalian longevity and suggest possible players involved in adaptive genetic changes conferring cancer resistance. We also found potentially relevant changes in genes related to additional processes, including thermoregulation, sensory perception, dietary adaptations, and immune response. Our data are made available online (http://www.bowhead-whale.org) to facilitate research in this long-lived species. Article in Journal/Newspaper Balaena mysticetus bowhead whale Directory of Open Access Journals: DOAJ Articles Cell Reports 10 1 112 122 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Biology (General) QH301-705.5 |
spellingShingle |
Biology (General) QH301-705.5 Michael Keane Jeremy Semeiks Andrew E. Webb Yang I. Li Víctor Quesada Thomas Craig Lone Bruhn Madsen Sipko van Dam David Brawand Patrícia I. Marques Pawel Michalak Lin Kang Jong Bhak Hyung-Soon Yim Nick V. Grishin Nynne Hjort Nielsen Mads Peter Heide-Jørgensen Elias M. Oziolor Cole W. Matson George M. Church Gary W. Stuart John C. Patton J. Craig George Robert Suydam Knud Larsen Carlos López-Otín Mary J. O’Connell John W. Bickham Bo Thomsen João Pedro de Magalhães Insights into the Evolution of Longevity from the Bowhead Whale Genome |
topic_facet |
Biology (General) QH301-705.5 |
description |
The bowhead whale (Balaena mysticetus) is estimated to live over 200 years and is possibly the longest-living mammal. These animals should possess protective molecular adaptations relevant to age-related diseases, particularly cancer. Here, we report the sequencing and comparative analysis of the bowhead whale genome and two transcriptomes from different populations. Our analysis identifies genes under positive selection and bowhead-specific mutations in genes linked to cancer and aging. In addition, we identify gene gain and loss involving genes associated with DNA repair, cell-cycle regulation, cancer, and aging. Our results expand our understanding of the evolution of mammalian longevity and suggest possible players involved in adaptive genetic changes conferring cancer resistance. We also found potentially relevant changes in genes related to additional processes, including thermoregulation, sensory perception, dietary adaptations, and immune response. Our data are made available online (http://www.bowhead-whale.org) to facilitate research in this long-lived species. |
format |
Article in Journal/Newspaper |
author |
Michael Keane Jeremy Semeiks Andrew E. Webb Yang I. Li Víctor Quesada Thomas Craig Lone Bruhn Madsen Sipko van Dam David Brawand Patrícia I. Marques Pawel Michalak Lin Kang Jong Bhak Hyung-Soon Yim Nick V. Grishin Nynne Hjort Nielsen Mads Peter Heide-Jørgensen Elias M. Oziolor Cole W. Matson George M. Church Gary W. Stuart John C. Patton J. Craig George Robert Suydam Knud Larsen Carlos López-Otín Mary J. O’Connell John W. Bickham Bo Thomsen João Pedro de Magalhães |
author_facet |
Michael Keane Jeremy Semeiks Andrew E. Webb Yang I. Li Víctor Quesada Thomas Craig Lone Bruhn Madsen Sipko van Dam David Brawand Patrícia I. Marques Pawel Michalak Lin Kang Jong Bhak Hyung-Soon Yim Nick V. Grishin Nynne Hjort Nielsen Mads Peter Heide-Jørgensen Elias M. Oziolor Cole W. Matson George M. Church Gary W. Stuart John C. Patton J. Craig George Robert Suydam Knud Larsen Carlos López-Otín Mary J. O’Connell John W. Bickham Bo Thomsen João Pedro de Magalhães |
author_sort |
Michael Keane |
title |
Insights into the Evolution of Longevity from the Bowhead Whale Genome |
title_short |
Insights into the Evolution of Longevity from the Bowhead Whale Genome |
title_full |
Insights into the Evolution of Longevity from the Bowhead Whale Genome |
title_fullStr |
Insights into the Evolution of Longevity from the Bowhead Whale Genome |
title_full_unstemmed |
Insights into the Evolution of Longevity from the Bowhead Whale Genome |
title_sort |
insights into the evolution of longevity from the bowhead whale genome |
publisher |
Elsevier |
publishDate |
2015 |
url |
https://doi.org/10.1016/j.celrep.2014.12.008 https://doaj.org/article/5cb71fcc599b4343858c3cc10a216423 |
genre |
Balaena mysticetus bowhead whale |
genre_facet |
Balaena mysticetus bowhead whale |
op_source |
Cell Reports, Vol 10, Iss 1, Pp 112-122 (2015) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2211124714010195 https://doaj.org/toc/2211-1247 2211-1247 doi:10.1016/j.celrep.2014.12.008 https://doaj.org/article/5cb71fcc599b4343858c3cc10a216423 |
op_doi |
https://doi.org/10.1016/j.celrep.2014.12.008 |
container_title |
Cell Reports |
container_volume |
10 |
container_issue |
1 |
container_start_page |
112 |
op_container_end_page |
122 |
_version_ |
1766366313735782400 |