Drivers of Echinococcus multilocularis transmission in China: small mammal diversity, landscape or climate?
Background Human alveolar echinococcocosis (AE) is a highly pathogenic zoonotic disease caused by the larval stage of the cestode E. multilocularis. Its life-cycle includes more than 40 species of small mammal intermediate hosts. Therefore, host biodiversity losses could be expected to alter transmi...
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ftdoajarticles:oai:doaj.org/article:5c82b0ad4f3144c0b0692be71c89f3f1 2023-05-15T15:15:45+02:00 Drivers of Echinococcus multilocularis transmission in China: small mammal diversity, landscape or climate? Patrick Giraudoux Francis Raoul David Pleydell Tiaoying Li Xiuming Han Jiamin Qiu Yan Xie Hu Wang Akira Ito Philip S Craig 2013-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0002045 https://doaj.org/article/5c82b0ad4f3144c0b0692be71c89f3f1 EN eng Public Library of Science (PLoS) https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23505582/?tool=EBI https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002045 https://doaj.org/article/5c82b0ad4f3144c0b0692be71c89f3f1 PLoS Neglected Tropical Diseases, Vol 7, Iss 3, p e2045 (2013) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2013 ftdoajarticles https://doi.org/10.1371/journal.pntd.0002045 2022-12-31T05:07:05Z Background Human alveolar echinococcocosis (AE) is a highly pathogenic zoonotic disease caused by the larval stage of the cestode E. multilocularis. Its life-cycle includes more than 40 species of small mammal intermediate hosts. Therefore, host biodiversity losses could be expected to alter transmission. Climate may also have possible impacts on E. multilocularis egg survival. We examined the distribution of human AE across two spatial scales, (i) for continental China and (ii) over the eastern edge of the Tibetan plateau. We tested the hypotheses that human disease distribution can be explained by either the biodiversity of small mammal intermediate host species, or by environmental factors such as climate or landscape characteristics. Methodology/findings The distributions of 274 small mammal species were mapped to 967 point locations on a grid covering continental China. Land cover, elevation, monthly rainfall and temperature were mapped using remotely sensed imagery and compared to the distribution of human AE disease at continental scale and over the eastern Tibetan plateau. Infection status of 17,589 people screened by abdominal ultrasound in 2002-2008 in 94 villages of Tibetan areas of western Sichuan and Qinghai provinces was analyzed using generalized additive mixed models and related to epidemiological and environmental covariates. We found that human AE was not directly correlated with small mammal reservoir host species richness, but rather was spatially correlated with landscape features and climate which could confirm and predict human disease hotspots over a 200,000 km(2) region. Conclusions/significance E. multilocularis transmission and resultant human disease risk was better predicted from landscape features that could support increases of small mammal host species prone to population outbreaks, rather than host species richness. We anticipate that our study may be a starting point for further research wherein landscape management could be used to predict human disease risk and for controlling ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 7 3 e2045 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Patrick Giraudoux Francis Raoul David Pleydell Tiaoying Li Xiuming Han Jiamin Qiu Yan Xie Hu Wang Akira Ito Philip S Craig Drivers of Echinococcus multilocularis transmission in China: small mammal diversity, landscape or climate? |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Human alveolar echinococcocosis (AE) is a highly pathogenic zoonotic disease caused by the larval stage of the cestode E. multilocularis. Its life-cycle includes more than 40 species of small mammal intermediate hosts. Therefore, host biodiversity losses could be expected to alter transmission. Climate may also have possible impacts on E. multilocularis egg survival. We examined the distribution of human AE across two spatial scales, (i) for continental China and (ii) over the eastern edge of the Tibetan plateau. We tested the hypotheses that human disease distribution can be explained by either the biodiversity of small mammal intermediate host species, or by environmental factors such as climate or landscape characteristics. Methodology/findings The distributions of 274 small mammal species were mapped to 967 point locations on a grid covering continental China. Land cover, elevation, monthly rainfall and temperature were mapped using remotely sensed imagery and compared to the distribution of human AE disease at continental scale and over the eastern Tibetan plateau. Infection status of 17,589 people screened by abdominal ultrasound in 2002-2008 in 94 villages of Tibetan areas of western Sichuan and Qinghai provinces was analyzed using generalized additive mixed models and related to epidemiological and environmental covariates. We found that human AE was not directly correlated with small mammal reservoir host species richness, but rather was spatially correlated with landscape features and climate which could confirm and predict human disease hotspots over a 200,000 km(2) region. Conclusions/significance E. multilocularis transmission and resultant human disease risk was better predicted from landscape features that could support increases of small mammal host species prone to population outbreaks, rather than host species richness. We anticipate that our study may be a starting point for further research wherein landscape management could be used to predict human disease risk and for controlling ... |
format |
Article in Journal/Newspaper |
author |
Patrick Giraudoux Francis Raoul David Pleydell Tiaoying Li Xiuming Han Jiamin Qiu Yan Xie Hu Wang Akira Ito Philip S Craig |
author_facet |
Patrick Giraudoux Francis Raoul David Pleydell Tiaoying Li Xiuming Han Jiamin Qiu Yan Xie Hu Wang Akira Ito Philip S Craig |
author_sort |
Patrick Giraudoux |
title |
Drivers of Echinococcus multilocularis transmission in China: small mammal diversity, landscape or climate? |
title_short |
Drivers of Echinococcus multilocularis transmission in China: small mammal diversity, landscape or climate? |
title_full |
Drivers of Echinococcus multilocularis transmission in China: small mammal diversity, landscape or climate? |
title_fullStr |
Drivers of Echinococcus multilocularis transmission in China: small mammal diversity, landscape or climate? |
title_full_unstemmed |
Drivers of Echinococcus multilocularis transmission in China: small mammal diversity, landscape or climate? |
title_sort |
drivers of echinococcus multilocularis transmission in china: small mammal diversity, landscape or climate? |
publisher |
Public Library of Science (PLoS) |
publishDate |
2013 |
url |
https://doi.org/10.1371/journal.pntd.0002045 https://doaj.org/article/5c82b0ad4f3144c0b0692be71c89f3f1 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 7, Iss 3, p e2045 (2013) |
op_relation |
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23505582/?tool=EBI https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002045 https://doaj.org/article/5c82b0ad4f3144c0b0692be71c89f3f1 |
op_doi |
https://doi.org/10.1371/journal.pntd.0002045 |
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PLoS Neglected Tropical Diseases |
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7 |
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3 |
container_start_page |
e2045 |
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1766346093824573440 |