Perceptions and acceptability of co-administered albendazole, ivermectin and azithromycin mass drug administration, among the health workforce and recipient communities in Ethiopia.
Several neglected tropical diseases (NTDs) employ mass drug administration (MDA) as part of their control or elimination strategies. This has historically required multiple distinct campaigns, each targeting one or more NTDs, representing a strain on both the recipient communities and the local heal...
Published in: | PLOS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , , , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2023
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0011332 https://doaj.org/article/5c7bd01ddd8e4aef919ee52114ba08c6 |
id |
ftdoajarticles:oai:doaj.org/article:5c7bd01ddd8e4aef919ee52114ba08c6 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:5c7bd01ddd8e4aef919ee52114ba08c6 2024-01-28T10:04:12+01:00 Perceptions and acceptability of co-administered albendazole, ivermectin and azithromycin mass drug administration, among the health workforce and recipient communities in Ethiopia. Scott McPherson Dereje Geleta Getinet Tafese Temesgen Tafese Sinkinesh Behaksira Hiwot Solomon Birhanu Oljira Hirpa Miecha Lalisa Gemechu Kaleab Debebe Biruck Kebede Teshome Gebre Fikreab Kebede Fikre Seife Fentahun Tadesse Belete Mammo Abraham Aseffa Anthony W Solomon David C W Mabey Michael Marks Endalamaw Gadisa 2023-10-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0011332 https://doaj.org/article/5c7bd01ddd8e4aef919ee52114ba08c6 EN eng Public Library of Science (PLoS) https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0011332&type=printable https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0011332 https://doaj.org/article/5c7bd01ddd8e4aef919ee52114ba08c6 PLoS Neglected Tropical Diseases, Vol 17, Iss 10, p e0011332 (2023) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2023 ftdoajarticles https://doi.org/10.1371/journal.pntd.0011332 2023-12-31T01:49:19Z Several neglected tropical diseases (NTDs) employ mass drug administration (MDA) as part of their control or elimination strategies. This has historically required multiple distinct campaigns, each targeting one or more NTDs, representing a strain on both the recipient communities and the local health workforce implementing the distribution. We explored perceptions and attitudes surrounding combined MDA among these two groups of stakeholders. Our qualitative study was nested within a cluster randomized non-inferiority safety trial of combined ivermectin, albendazole and azithromycin MDA. Using semi-structured question guides, we conducted 16 key informant interviews with selected individuals involved in implementing MDA within the participating district. To better understand the perceptions of recipient communities, we also conducted four focus group discussions with key community groups. Individuals were selected from both the trial arm (integrated MDA) and the control arm (standard MDA) to provide a means of comparison and discussion. All interviews and focus group discussions were led by fluent Afaan oromo speakers. Interviewers transcribed and later translated all discussions into English. The study team synthesized and analyzed the results via a coding framework and software. Most respondents appreciated the time and effort saved via the co-administered MDA strategy but there were some misgivings amongst community beneficiaries surrounding pill burden. Both the implementing health work force members and beneficiaries reported refusals stemming from lack of understanding around the need for the new drug regimen as well as some mistrust of government officials among the youth. The house-to-house distribution method, adopted as a COVID-19 prevention strategy, was by far preferred by all beneficiaries over central-point MDA, and may have led to greater acceptability of co-administration. Our data demonstrate that a co-administration strategy for NTDs is acceptable to both communities and health staff. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 17 10 e0011332 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Scott McPherson Dereje Geleta Getinet Tafese Temesgen Tafese Sinkinesh Behaksira Hiwot Solomon Birhanu Oljira Hirpa Miecha Lalisa Gemechu Kaleab Debebe Biruck Kebede Teshome Gebre Fikreab Kebede Fikre Seife Fentahun Tadesse Belete Mammo Abraham Aseffa Anthony W Solomon David C W Mabey Michael Marks Endalamaw Gadisa Perceptions and acceptability of co-administered albendazole, ivermectin and azithromycin mass drug administration, among the health workforce and recipient communities in Ethiopia. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Several neglected tropical diseases (NTDs) employ mass drug administration (MDA) as part of their control or elimination strategies. This has historically required multiple distinct campaigns, each targeting one or more NTDs, representing a strain on both the recipient communities and the local health workforce implementing the distribution. We explored perceptions and attitudes surrounding combined MDA among these two groups of stakeholders. Our qualitative study was nested within a cluster randomized non-inferiority safety trial of combined ivermectin, albendazole and azithromycin MDA. Using semi-structured question guides, we conducted 16 key informant interviews with selected individuals involved in implementing MDA within the participating district. To better understand the perceptions of recipient communities, we also conducted four focus group discussions with key community groups. Individuals were selected from both the trial arm (integrated MDA) and the control arm (standard MDA) to provide a means of comparison and discussion. All interviews and focus group discussions were led by fluent Afaan oromo speakers. Interviewers transcribed and later translated all discussions into English. The study team synthesized and analyzed the results via a coding framework and software. Most respondents appreciated the time and effort saved via the co-administered MDA strategy but there were some misgivings amongst community beneficiaries surrounding pill burden. Both the implementing health work force members and beneficiaries reported refusals stemming from lack of understanding around the need for the new drug regimen as well as some mistrust of government officials among the youth. The house-to-house distribution method, adopted as a COVID-19 prevention strategy, was by far preferred by all beneficiaries over central-point MDA, and may have led to greater acceptability of co-administration. Our data demonstrate that a co-administration strategy for NTDs is acceptable to both communities and health staff. |
format |
Article in Journal/Newspaper |
author |
Scott McPherson Dereje Geleta Getinet Tafese Temesgen Tafese Sinkinesh Behaksira Hiwot Solomon Birhanu Oljira Hirpa Miecha Lalisa Gemechu Kaleab Debebe Biruck Kebede Teshome Gebre Fikreab Kebede Fikre Seife Fentahun Tadesse Belete Mammo Abraham Aseffa Anthony W Solomon David C W Mabey Michael Marks Endalamaw Gadisa |
author_facet |
Scott McPherson Dereje Geleta Getinet Tafese Temesgen Tafese Sinkinesh Behaksira Hiwot Solomon Birhanu Oljira Hirpa Miecha Lalisa Gemechu Kaleab Debebe Biruck Kebede Teshome Gebre Fikreab Kebede Fikre Seife Fentahun Tadesse Belete Mammo Abraham Aseffa Anthony W Solomon David C W Mabey Michael Marks Endalamaw Gadisa |
author_sort |
Scott McPherson |
title |
Perceptions and acceptability of co-administered albendazole, ivermectin and azithromycin mass drug administration, among the health workforce and recipient communities in Ethiopia. |
title_short |
Perceptions and acceptability of co-administered albendazole, ivermectin and azithromycin mass drug administration, among the health workforce and recipient communities in Ethiopia. |
title_full |
Perceptions and acceptability of co-administered albendazole, ivermectin and azithromycin mass drug administration, among the health workforce and recipient communities in Ethiopia. |
title_fullStr |
Perceptions and acceptability of co-administered albendazole, ivermectin and azithromycin mass drug administration, among the health workforce and recipient communities in Ethiopia. |
title_full_unstemmed |
Perceptions and acceptability of co-administered albendazole, ivermectin and azithromycin mass drug administration, among the health workforce and recipient communities in Ethiopia. |
title_sort |
perceptions and acceptability of co-administered albendazole, ivermectin and azithromycin mass drug administration, among the health workforce and recipient communities in ethiopia. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2023 |
url |
https://doi.org/10.1371/journal.pntd.0011332 https://doaj.org/article/5c7bd01ddd8e4aef919ee52114ba08c6 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 17, Iss 10, p e0011332 (2023) |
op_relation |
https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0011332&type=printable https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0011332 https://doaj.org/article/5c7bd01ddd8e4aef919ee52114ba08c6 |
op_doi |
https://doi.org/10.1371/journal.pntd.0011332 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
17 |
container_issue |
10 |
container_start_page |
e0011332 |
_version_ |
1789329805433372672 |