Therapeutic efficacy of artesunate–amodiaquine and artemether–lumefantrine combinations for uncomplicated malaria in 10 sentinel sites across Ghana: 2015–2017
Abstract Background Routine surveillance on the therapeutic efficacy of artemisinin-based combination therapy (ACT) has been ongoing in Ghana since 2005. The sixth round of surveillance was conducted between 2015 and 2017 to determine the therapeutic efficacy of artesunate–amodiaquine (AS–AQ) and ar...
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ftdoajarticles:oai:doaj.org/article:5c3f88f0c8984155a411aa3e62b13dc3 2023-05-15T15:17:55+02:00 Therapeutic efficacy of artesunate–amodiaquine and artemether–lumefantrine combinations for uncomplicated malaria in 10 sentinel sites across Ghana: 2015–2017 Benjamin Abuaku Nancy O. Duah-Quashie Lydia Quaye Sena A. Matrevi Neils Quashie Akosua Gyasi Felicia Owusu-Antwi Keziah Malm Kwadwo Koram 2019-06-01T00:00:00Z https://doi.org/10.1186/s12936-019-2848-1 https://doaj.org/article/5c3f88f0c8984155a411aa3e62b13dc3 EN eng BMC http://link.springer.com/article/10.1186/s12936-019-2848-1 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-2848-1 1475-2875 https://doaj.org/article/5c3f88f0c8984155a411aa3e62b13dc3 Malaria Journal, Vol 18, Iss 1, Pp 1-12 (2019) Therapeutic efficacy Artesunate–amodiaquine Artemether–lumefantrine Uncomplicated malaria Sentinel sites Ghana Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2019 ftdoajarticles https://doi.org/10.1186/s12936-019-2848-1 2022-12-31T00:18:08Z Abstract Background Routine surveillance on the therapeutic efficacy of artemisinin-based combination therapy (ACT) has been ongoing in Ghana since 2005. The sixth round of surveillance was conducted between 2015 and 2017 to determine the therapeutic efficacy of artesunate–amodiaquine (AS–AQ) and artemether–lumefantrine (AL) in 10 sentinel sites across the country. Methods The study was a one-arm, prospective, evaluation of the clinical, parasitological, and haematological responses to directly observed treatment with AS–AQ and AL among children 6 months to 9 years old with uncomplicated falciparum malaria. The WHO 2009 protocol on surveillance of anti-malaria drug efficacy was used for the study with primary outcomes as prevalence of day 3 parasitaemia and clinical and parasitological cure rates on day 28. Secondary outcomes assessed included patterns of fever and parasite clearance as well as changes in haemoglobin concentration. Results Day 3 parasitaemia was absent in all sites following treatment with AS–AQ whilst only one person (0.2%) was parasitaemic on day 3 following treatment with AL. Day 28 PCR-corrected cure rates following treatment with AS–AQ ranged between 96.7% (95% CI 88.5–99.6) and 100%, yielding a national rate of 99.2% (95% CI 97.7–99.7). Day 28 PCR-corrected cure rates following treatment with AL ranged between 91.3% (95% CI 79.2–97.6) and 100%, yielding a national rate of 96% (95% CI 93.5–97.6). Prevalence of fever declined by 88.4 and 80.4% after first day of treatment with AS–AQ and AL, respectively, whilst prevalence of parasitaemia on day 2 was 2.1% for AS–AQ and 1.5% for AL. Gametocytaemia was maintained at low levels (< 5%) during the 3 days of treatment. Post-treatment mean haemoglobin concentration was significantly higher than pre-treatment concentration following treatment with either AS–AQ or AL. Conclusions The therapeutic efficacy of AS–AQ and AL is over 90% in sentinel sites across Ghana. The two anti-malarial drugs therefore remain efficacious in the treatment of ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 18 1 |
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topic |
Therapeutic efficacy Artesunate–amodiaquine Artemether–lumefantrine Uncomplicated malaria Sentinel sites Ghana Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Therapeutic efficacy Artesunate–amodiaquine Artemether–lumefantrine Uncomplicated malaria Sentinel sites Ghana Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Benjamin Abuaku Nancy O. Duah-Quashie Lydia Quaye Sena A. Matrevi Neils Quashie Akosua Gyasi Felicia Owusu-Antwi Keziah Malm Kwadwo Koram Therapeutic efficacy of artesunate–amodiaquine and artemether–lumefantrine combinations for uncomplicated malaria in 10 sentinel sites across Ghana: 2015–2017 |
topic_facet |
Therapeutic efficacy Artesunate–amodiaquine Artemether–lumefantrine Uncomplicated malaria Sentinel sites Ghana Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Routine surveillance on the therapeutic efficacy of artemisinin-based combination therapy (ACT) has been ongoing in Ghana since 2005. The sixth round of surveillance was conducted between 2015 and 2017 to determine the therapeutic efficacy of artesunate–amodiaquine (AS–AQ) and artemether–lumefantrine (AL) in 10 sentinel sites across the country. Methods The study was a one-arm, prospective, evaluation of the clinical, parasitological, and haematological responses to directly observed treatment with AS–AQ and AL among children 6 months to 9 years old with uncomplicated falciparum malaria. The WHO 2009 protocol on surveillance of anti-malaria drug efficacy was used for the study with primary outcomes as prevalence of day 3 parasitaemia and clinical and parasitological cure rates on day 28. Secondary outcomes assessed included patterns of fever and parasite clearance as well as changes in haemoglobin concentration. Results Day 3 parasitaemia was absent in all sites following treatment with AS–AQ whilst only one person (0.2%) was parasitaemic on day 3 following treatment with AL. Day 28 PCR-corrected cure rates following treatment with AS–AQ ranged between 96.7% (95% CI 88.5–99.6) and 100%, yielding a national rate of 99.2% (95% CI 97.7–99.7). Day 28 PCR-corrected cure rates following treatment with AL ranged between 91.3% (95% CI 79.2–97.6) and 100%, yielding a national rate of 96% (95% CI 93.5–97.6). Prevalence of fever declined by 88.4 and 80.4% after first day of treatment with AS–AQ and AL, respectively, whilst prevalence of parasitaemia on day 2 was 2.1% for AS–AQ and 1.5% for AL. Gametocytaemia was maintained at low levels (< 5%) during the 3 days of treatment. Post-treatment mean haemoglobin concentration was significantly higher than pre-treatment concentration following treatment with either AS–AQ or AL. Conclusions The therapeutic efficacy of AS–AQ and AL is over 90% in sentinel sites across Ghana. The two anti-malarial drugs therefore remain efficacious in the treatment of ... |
format |
Article in Journal/Newspaper |
author |
Benjamin Abuaku Nancy O. Duah-Quashie Lydia Quaye Sena A. Matrevi Neils Quashie Akosua Gyasi Felicia Owusu-Antwi Keziah Malm Kwadwo Koram |
author_facet |
Benjamin Abuaku Nancy O. Duah-Quashie Lydia Quaye Sena A. Matrevi Neils Quashie Akosua Gyasi Felicia Owusu-Antwi Keziah Malm Kwadwo Koram |
author_sort |
Benjamin Abuaku |
title |
Therapeutic efficacy of artesunate–amodiaquine and artemether–lumefantrine combinations for uncomplicated malaria in 10 sentinel sites across Ghana: 2015–2017 |
title_short |
Therapeutic efficacy of artesunate–amodiaquine and artemether–lumefantrine combinations for uncomplicated malaria in 10 sentinel sites across Ghana: 2015–2017 |
title_full |
Therapeutic efficacy of artesunate–amodiaquine and artemether–lumefantrine combinations for uncomplicated malaria in 10 sentinel sites across Ghana: 2015–2017 |
title_fullStr |
Therapeutic efficacy of artesunate–amodiaquine and artemether–lumefantrine combinations for uncomplicated malaria in 10 sentinel sites across Ghana: 2015–2017 |
title_full_unstemmed |
Therapeutic efficacy of artesunate–amodiaquine and artemether–lumefantrine combinations for uncomplicated malaria in 10 sentinel sites across Ghana: 2015–2017 |
title_sort |
therapeutic efficacy of artesunate–amodiaquine and artemether–lumefantrine combinations for uncomplicated malaria in 10 sentinel sites across ghana: 2015–2017 |
publisher |
BMC |
publishDate |
2019 |
url |
https://doi.org/10.1186/s12936-019-2848-1 https://doaj.org/article/5c3f88f0c8984155a411aa3e62b13dc3 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 18, Iss 1, Pp 1-12 (2019) |
op_relation |
http://link.springer.com/article/10.1186/s12936-019-2848-1 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-2848-1 1475-2875 https://doaj.org/article/5c3f88f0c8984155a411aa3e62b13dc3 |
op_doi |
https://doi.org/10.1186/s12936-019-2848-1 |
container_title |
Malaria Journal |
container_volume |
18 |
container_issue |
1 |
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1766348172039290880 |