Characterization of the primary antibody response to Plasmodium falciparum antigens in infants living in a malaria-endemic area
Abstract Background The primary antibody (Ab) response to Plasmodium falciparum is a critical step in developing immunity to malaria. Information on the initial Ab responses of babies in malaria-endemic areas is incomplete, in part, because babies receive maternal IgG via transplacental-transfer and...
Published in: | Malaria Journal |
---|---|
Main Authors: | , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
BMC
2022
|
Subjects: | |
Online Access: | https://doi.org/10.1186/s12936-022-04360-x https://doaj.org/article/5c35799565b24baebf08b90e0dbb54e5 |
id |
ftdoajarticles:oai:doaj.org/article:5c35799565b24baebf08b90e0dbb54e5 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:5c35799565b24baebf08b90e0dbb54e5 2023-05-15T15:17:36+02:00 Characterization of the primary antibody response to Plasmodium falciparum antigens in infants living in a malaria-endemic area Samuel Tassi Yunga Chathura Siriwardhana Genevieve G. Fouda Naveen Bobbili Grace Sama John J. Chen Rose F. G. Leke Diane Wallace Taylor 2022-11-01T00:00:00Z https://doi.org/10.1186/s12936-022-04360-x https://doaj.org/article/5c35799565b24baebf08b90e0dbb54e5 EN eng BMC https://doi.org/10.1186/s12936-022-04360-x https://doaj.org/toc/1475-2875 doi:10.1186/s12936-022-04360-x 1475-2875 https://doaj.org/article/5c35799565b24baebf08b90e0dbb54e5 Malaria Journal, Vol 21, Iss 1, Pp 1-14 (2022) Malaria Plasmodium falciparum First antibody response Babies IgM IgG Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2022 ftdoajarticles https://doi.org/10.1186/s12936-022-04360-x 2022-12-30T21:14:41Z Abstract Background The primary antibody (Ab) response to Plasmodium falciparum is a critical step in developing immunity to malaria. Information on the initial Ab responses of babies in malaria-endemic areas is incomplete, in part, because babies receive maternal IgG via transplacental-transfer and usually become infected before maternal IgG wanes. The study aimed to identify the primary IgM and IgG Ab responses to malarial antigens in Cameroonian babies. Methods Infants (n = 70) living in a high malaria transmission area were followed from birth throughout the first year of life (mean 341 ± 42 days, an average of 8.5 time points per infant). Malaria infection was assessed by microscopy and PCR, and IgM and IgG antibodies (Abs) were measured using a multiplex immunoassay to AMA1, EBA-175, MSP1-42, MSP2, MSP3, RESA, LSA1, and CSP. Results The half-life of maternal IgG varied among the antigens, ranging from 0.7 to 2.5 months. The first infection of 41% of the babies was sub-microscopic and only 11 to 44% of the babies produced IgM to the above antigens; however, when the first infection was detected by microscopy, 59–82% of the infants made IgM Abs to the antigens. Infants were able to produce IgM even when maternal IgG was present, suggesting maternal Abs did not suppress the baby’s initial Ab response. Using longitudinal regression models that incorporated time-varying covariates, infants were found to produce IgG Ab to only AMA-1 when the first infection was sub-microscopic, but they produced IgG Abs to MSP1-42 (3D7, FVO), AMA1 (3D7, FVO) MSP2-FC27, MSP3, RESA, and LSA1, but not MSP 2-3D7, EBA-175, and CSP during their first slide-positive infection. Notably, the primary and secondary IgG responses were short-lived with little evidence of boosting. Conclusions The primary Ab response of babies who had maternal IgG was similar to that reported for primary infections in malaria-naïve adults. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 21 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Malaria Plasmodium falciparum First antibody response Babies IgM IgG Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Malaria Plasmodium falciparum First antibody response Babies IgM IgG Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Samuel Tassi Yunga Chathura Siriwardhana Genevieve G. Fouda Naveen Bobbili Grace Sama John J. Chen Rose F. G. Leke Diane Wallace Taylor Characterization of the primary antibody response to Plasmodium falciparum antigens in infants living in a malaria-endemic area |
topic_facet |
Malaria Plasmodium falciparum First antibody response Babies IgM IgG Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background The primary antibody (Ab) response to Plasmodium falciparum is a critical step in developing immunity to malaria. Information on the initial Ab responses of babies in malaria-endemic areas is incomplete, in part, because babies receive maternal IgG via transplacental-transfer and usually become infected before maternal IgG wanes. The study aimed to identify the primary IgM and IgG Ab responses to malarial antigens in Cameroonian babies. Methods Infants (n = 70) living in a high malaria transmission area were followed from birth throughout the first year of life (mean 341 ± 42 days, an average of 8.5 time points per infant). Malaria infection was assessed by microscopy and PCR, and IgM and IgG antibodies (Abs) were measured using a multiplex immunoassay to AMA1, EBA-175, MSP1-42, MSP2, MSP3, RESA, LSA1, and CSP. Results The half-life of maternal IgG varied among the antigens, ranging from 0.7 to 2.5 months. The first infection of 41% of the babies was sub-microscopic and only 11 to 44% of the babies produced IgM to the above antigens; however, when the first infection was detected by microscopy, 59–82% of the infants made IgM Abs to the antigens. Infants were able to produce IgM even when maternal IgG was present, suggesting maternal Abs did not suppress the baby’s initial Ab response. Using longitudinal regression models that incorporated time-varying covariates, infants were found to produce IgG Ab to only AMA-1 when the first infection was sub-microscopic, but they produced IgG Abs to MSP1-42 (3D7, FVO), AMA1 (3D7, FVO) MSP2-FC27, MSP3, RESA, and LSA1, but not MSP 2-3D7, EBA-175, and CSP during their first slide-positive infection. Notably, the primary and secondary IgG responses were short-lived with little evidence of boosting. Conclusions The primary Ab response of babies who had maternal IgG was similar to that reported for primary infections in malaria-naïve adults. |
format |
Article in Journal/Newspaper |
author |
Samuel Tassi Yunga Chathura Siriwardhana Genevieve G. Fouda Naveen Bobbili Grace Sama John J. Chen Rose F. G. Leke Diane Wallace Taylor |
author_facet |
Samuel Tassi Yunga Chathura Siriwardhana Genevieve G. Fouda Naveen Bobbili Grace Sama John J. Chen Rose F. G. Leke Diane Wallace Taylor |
author_sort |
Samuel Tassi Yunga |
title |
Characterization of the primary antibody response to Plasmodium falciparum antigens in infants living in a malaria-endemic area |
title_short |
Characterization of the primary antibody response to Plasmodium falciparum antigens in infants living in a malaria-endemic area |
title_full |
Characterization of the primary antibody response to Plasmodium falciparum antigens in infants living in a malaria-endemic area |
title_fullStr |
Characterization of the primary antibody response to Plasmodium falciparum antigens in infants living in a malaria-endemic area |
title_full_unstemmed |
Characterization of the primary antibody response to Plasmodium falciparum antigens in infants living in a malaria-endemic area |
title_sort |
characterization of the primary antibody response to plasmodium falciparum antigens in infants living in a malaria-endemic area |
publisher |
BMC |
publishDate |
2022 |
url |
https://doi.org/10.1186/s12936-022-04360-x https://doaj.org/article/5c35799565b24baebf08b90e0dbb54e5 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 21, Iss 1, Pp 1-14 (2022) |
op_relation |
https://doi.org/10.1186/s12936-022-04360-x https://doaj.org/toc/1475-2875 doi:10.1186/s12936-022-04360-x 1475-2875 https://doaj.org/article/5c35799565b24baebf08b90e0dbb54e5 |
op_doi |
https://doi.org/10.1186/s12936-022-04360-x |
container_title |
Malaria Journal |
container_volume |
21 |
container_issue |
1 |
_version_ |
1766347831285645312 |