Lymphoepithelial carcinoma of the parotid gland

• Published in: SAGE Open Medical Case Reports
• Main Authors: Souha Kallel, Sirine Ayadi, Noura Salem, Mouna Zghal, Ben Ayed Mariem, Lobna Ayedi, Malek Mnejja, Tahya Boudawara, Ilhem Charfeddine
• Format: Article in Journal/Newspaper
• Language: English
• Published: SAGE Publishing 2024
• Subjects: Medicine (General); R5-920; inuit
• Online Access: https://doi.org/10.1177/2050313X241260210; https://doaj.org/article/5bea6e40d25d4d70b8040c76a6376b86

Primary lymphoepithelial carcinoma of the salivary glands is an exceptional oncological condition that predominantly emerges within the parotid gland. A significant prevalence of lymphoepithelial carcinoma has been reported in the Inuit population, along with an associated positive serology for Epstein-Barr virus in these endemic regions. In this paper, we present a case of primary lymphoepithelial carcinoma of the parotid gland in a 68-year-old female patient with a history of diabetes and hypertension residing in a non-endemic area. Histology plays a critical role in the definitive diagnosis, and confirming the primary origin of lymphoepithelial carcinoma after ruling out metastasis from undifferentiated nasopharyngeal carcinoma. The mainstay of treatment is a combination of surgical resection and adjuvant radiotherapy. Inoperable forms are typically managed with chemoradiotherapy.