Dodecapeptide Cathelicidins of Cetartiodactyla: Structure, Mechanism of Antimicrobial Action, and Synergistic Interaction With Other Cathelicidins

• Published in: Frontiers in Microbiology
• Main Authors: Ilia A. Bolosov, Pavel V. Panteleev, Sergei V. Sychev, Stanislav V. Sukhanov, Pavel A. Mironov, Mikhail Yu. Myshkin, Zakhar O. Shenkarev, Tatiana V. Ovchinnikova
• Format: Article in Journal/Newspaper
• Language: English
• Published: Frontiers Media S.A. 2021
• Subjects: antimicrobial peptide; cathelicidin; dodecapeptide; goat; synergy; NMR; Microbiology; QR1-502; Catodon; Sperm whale
• Online Access: https://doi.org/10.3389/fmicb.2021.725526; https://doaj.org/article/5bdff750a9d0479a9f0fb4bd9d62559d

In this study, dodecapeptide cathelicidins were shown to be widespread antimicrobial peptides among the Cetruminantia clade. In particular, we investigated the dodecapeptide from the domestic goat Capra hircus, designated as ChDode and its unique ortholog from the sperm whale Physeter catodon (PcDod...