Community-based mass treatment with azithromycin for the elimination of yaws in Ghana-Results of a pilot study.
INTRODUCTION:The WHO yaws eradication strategy consists of one round of total community treatment (TCT) of single-dose azithromycin with coverage of > 90%.The efficacy of the strategy to reduce the levels on infection has been demonstrated previously in isolated island communities in the Pacific...
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ftdoajarticles:oai:doaj.org/article:5bbb5f2445374970a909e60e1950018c 2023-05-15T15:17:45+02:00 Community-based mass treatment with azithromycin for the elimination of yaws in Ghana-Results of a pilot study. Abdul Aziz Abdulai Patrick Agana-Nsiire Frank Biney Cynthia Kwakye-Maclean Sardick Kyei-Faried Kwame Amponsa-Achiano Shirley Victoria Simpson George Bonsu Sally-Ann Ohene William Kwabena Ampofo Yaw Adu-Sarkodie Kennedy Kwasi Addo Kai-Hua Chi Damien Danavall Cheng Y Chen Allan Pillay Sergi Sanz Ye Tun Oriol Mitjà Kingsley Bampoe Asiedu Ronald C Ballard 2018-03-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0006303 https://doaj.org/article/5bbb5f2445374970a909e60e1950018c EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5863939?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006303 https://doaj.org/article/5bbb5f2445374970a909e60e1950018c PLoS Neglected Tropical Diseases, Vol 12, Iss 3, p e0006303 (2018) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2018 ftdoajarticles https://doi.org/10.1371/journal.pntd.0006303 2022-12-31T06:03:55Z INTRODUCTION:The WHO yaws eradication strategy consists of one round of total community treatment (TCT) of single-dose azithromycin with coverage of > 90%.The efficacy of the strategy to reduce the levels on infection has been demonstrated previously in isolated island communities in the Pacific region. We aimed to determine the efficacy of a single round of TCT with azithromycin to achieve a decrease in yaws prevalence in communities that are endemic for yaws and surrounded by other yaws-endemic areas. METHODS:Surveys for yaws seroprevalence and prevalence of skin lesions were conducted among schoolchildren aged 5-15 years before and one year after the TCT intervention in the Abamkrom sub-district of Ghana. We used a cluster design with the schools as the primary sampling unit. Among 20 eligible primary schools in the sub district, 10 were assigned to the baseline survey and 10 to the post-TCT survey. The field teams conducted a physical examination for skin lesions and a dual point-of-care immunoassay for non-treponemal and treponemal antibodies of all children present at the time of the visit. We also undertook surveys with non-probabilistic sampling to collect lesion swabs for etiology and macrolide resistance assessment. RESULTS:At baseline 14,548 (89%) of 16,287 population in the sub-district received treatment during TCT. Following one round of TCT, the prevalence of dual seropositivity among all children decreased from 10.9% (103/943) pre-TCT to 2.2% (27/1211) post-TCT (OR 0.19; 95%CI 0.09-0.37). The prevalence of serologically confirmed skin lesions consistent with active yaws was reduced from 5.7% (54/943) pre-TCT to 0.6% (7/1211) post-TCT (OR 0.10; 95% CI 0.25-0.35). No evidence of resistance to macrolides against Treponema pallidum subsp. pertenue was seen. DISCUSSION:A single round of high coverage TCT with azithromycin in a yaws affected sub-district adjoining other endemic areas is effective in reducing the prevalence of seropositive children and the prevalence of early skin lesions consistent ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Pacific PLOS Neglected Tropical Diseases 12 3 e0006303 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Abdul Aziz Abdulai Patrick Agana-Nsiire Frank Biney Cynthia Kwakye-Maclean Sardick Kyei-Faried Kwame Amponsa-Achiano Shirley Victoria Simpson George Bonsu Sally-Ann Ohene William Kwabena Ampofo Yaw Adu-Sarkodie Kennedy Kwasi Addo Kai-Hua Chi Damien Danavall Cheng Y Chen Allan Pillay Sergi Sanz Ye Tun Oriol Mitjà Kingsley Bampoe Asiedu Ronald C Ballard Community-based mass treatment with azithromycin for the elimination of yaws in Ghana-Results of a pilot study. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
INTRODUCTION:The WHO yaws eradication strategy consists of one round of total community treatment (TCT) of single-dose azithromycin with coverage of > 90%.The efficacy of the strategy to reduce the levels on infection has been demonstrated previously in isolated island communities in the Pacific region. We aimed to determine the efficacy of a single round of TCT with azithromycin to achieve a decrease in yaws prevalence in communities that are endemic for yaws and surrounded by other yaws-endemic areas. METHODS:Surveys for yaws seroprevalence and prevalence of skin lesions were conducted among schoolchildren aged 5-15 years before and one year after the TCT intervention in the Abamkrom sub-district of Ghana. We used a cluster design with the schools as the primary sampling unit. Among 20 eligible primary schools in the sub district, 10 were assigned to the baseline survey and 10 to the post-TCT survey. The field teams conducted a physical examination for skin lesions and a dual point-of-care immunoassay for non-treponemal and treponemal antibodies of all children present at the time of the visit. We also undertook surveys with non-probabilistic sampling to collect lesion swabs for etiology and macrolide resistance assessment. RESULTS:At baseline 14,548 (89%) of 16,287 population in the sub-district received treatment during TCT. Following one round of TCT, the prevalence of dual seropositivity among all children decreased from 10.9% (103/943) pre-TCT to 2.2% (27/1211) post-TCT (OR 0.19; 95%CI 0.09-0.37). The prevalence of serologically confirmed skin lesions consistent with active yaws was reduced from 5.7% (54/943) pre-TCT to 0.6% (7/1211) post-TCT (OR 0.10; 95% CI 0.25-0.35). No evidence of resistance to macrolides against Treponema pallidum subsp. pertenue was seen. DISCUSSION:A single round of high coverage TCT with azithromycin in a yaws affected sub-district adjoining other endemic areas is effective in reducing the prevalence of seropositive children and the prevalence of early skin lesions consistent ... |
format |
Article in Journal/Newspaper |
author |
Abdul Aziz Abdulai Patrick Agana-Nsiire Frank Biney Cynthia Kwakye-Maclean Sardick Kyei-Faried Kwame Amponsa-Achiano Shirley Victoria Simpson George Bonsu Sally-Ann Ohene William Kwabena Ampofo Yaw Adu-Sarkodie Kennedy Kwasi Addo Kai-Hua Chi Damien Danavall Cheng Y Chen Allan Pillay Sergi Sanz Ye Tun Oriol Mitjà Kingsley Bampoe Asiedu Ronald C Ballard |
author_facet |
Abdul Aziz Abdulai Patrick Agana-Nsiire Frank Biney Cynthia Kwakye-Maclean Sardick Kyei-Faried Kwame Amponsa-Achiano Shirley Victoria Simpson George Bonsu Sally-Ann Ohene William Kwabena Ampofo Yaw Adu-Sarkodie Kennedy Kwasi Addo Kai-Hua Chi Damien Danavall Cheng Y Chen Allan Pillay Sergi Sanz Ye Tun Oriol Mitjà Kingsley Bampoe Asiedu Ronald C Ballard |
author_sort |
Abdul Aziz Abdulai |
title |
Community-based mass treatment with azithromycin for the elimination of yaws in Ghana-Results of a pilot study. |
title_short |
Community-based mass treatment with azithromycin for the elimination of yaws in Ghana-Results of a pilot study. |
title_full |
Community-based mass treatment with azithromycin for the elimination of yaws in Ghana-Results of a pilot study. |
title_fullStr |
Community-based mass treatment with azithromycin for the elimination of yaws in Ghana-Results of a pilot study. |
title_full_unstemmed |
Community-based mass treatment with azithromycin for the elimination of yaws in Ghana-Results of a pilot study. |
title_sort |
community-based mass treatment with azithromycin for the elimination of yaws in ghana-results of a pilot study. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2018 |
url |
https://doi.org/10.1371/journal.pntd.0006303 https://doaj.org/article/5bbb5f2445374970a909e60e1950018c |
geographic |
Arctic Pacific |
geographic_facet |
Arctic Pacific |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 12, Iss 3, p e0006303 (2018) |
op_relation |
http://europepmc.org/articles/PMC5863939?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006303 https://doaj.org/article/5bbb5f2445374970a909e60e1950018c |
op_doi |
https://doi.org/10.1371/journal.pntd.0006303 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
12 |
container_issue |
3 |
container_start_page |
e0006303 |
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1766347994265812992 |