Increased osmotic sensitivity for antidiuretic response in chronic chagas' disease

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Joel Paulo Russomano Veiga, Tatsuto Kimachi, Euclydes Custódio Lima Filho, Luiz Fernando Junqueira Jr
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 1985
• Subjects: Doença de Chagas; Limiar osmótico; Resposta antídiurética; Desnervação hipotalâmica; Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.1590/S0037-86821985000200005; https://doaj.org/article/5bb8d9bd804c4d8095d44a2c9596ff95

The osmotic threshold for attaining the antidiuretic response to hypertonic saline infusion and Progressive dehydration was studied in 31 patients with the chronic form of Chagas' disease and 16 control patients. The chagasic patients exhibited enhanced osmoticsensitivity to the antidiuretic response. This was demonstrated by lower values of the increments in plasma osmolarity sufficient to induce a significant fall in water clearance, without alterations in the osmolar clearance or creatinine excretion. The time needed to attain the antidiuretic response was shorterfor chagasics in relation to normal subjects. The results suggest the existence of a disturbance in the fine control of osmoregulation in the chagasic patients. They are interpreted to be a consequence of the denervation in hypothalamic or extrahypothalamic areas that regulate the secretion of vasopressin in chronic Chagas' disease.