Genotype®MTBDRplus and Xpert®MTB/RIF in the diagnosis of tuberculosis and resistant tuberculosis: cost analysis in a tertiary referral hospital

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Valéria Martins Soares, Isabela Neves de Almeida, Maria Cláudia Vater, Suely Alves, Lida Jouca de Assis Figueredo, Luciene Scherer, Afrânio Lineu Kritski, Wânia da Silva Carvalho, Silvana Spindola de Miranda
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT)
• Subjects: tuberculosis; mycobacteria; diagnosis; mean cost; activity based cost; Arctic medicine. Tropical medicine; RC955-962; Arctic; Rif
• Online Access: https://doi.org/10.1590/0037-8682-0175-2019; https://doaj.org/article/5b99115ef055430e804b3c90e167f1e0

Abstract INTRODUCTION: The present study sought to assess the mean and activity based cost (ABC) of the laboratory diagnosis for tuberculosis through the application of conventional and molecular techniques-Xpert®MTB/RIF and Genotype®MTBDRplus-in a tertiary referral hospital in Brazil. METHODS: The mean cost and ABC formed the basis for the cost analysis of the TB laboratory diagnosis. RESULTS: The mean cost and ABC were US$ 4.00 and US$ 3.24, respectively, for a bacilloscopy; US$ 6.73 and US$ 5.27 for a Lowenstein-Jensen (LJ) culture; US$ 105.42 and US$ 76.56 for a drug sensitivity test (DST)-proportions method (PM) in LJ; US$ 148.45 and US$ 136.80 for a DST-BACTECTM MGITTM 960 system; US$ 11.53 and US$ 9.89 for an Xpert®MTB/RIF; and US$ 84.21 and US$ 48.38 for a Genotype®MTBDRplus. CONCLUSIONS: The mean cost and ABC proved to be good decision-making parameters in the diagnosis of TB and MDR-TB. The effective implementation of algorithms will depend on the conditions at each location.