In vivo anti-salmonella activity of aqueous extract of Euphorbia prostrata Aiton (Euphorbiaceae) and its toxicological evaluation
Objective: To investigate the in vivo anti-salmonella activity and the safety of aqueous extract of Euphorbia prostratra (E. prostratra), a plant commonly used in Cameroon by traditional healers. Methods: A Salmonella typhimurium-infected rat model was used for the study. The physiological, biochemi...
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Wolters Kluwer Medknow Publications
2015
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ftdoajarticles:oai:doaj.org/article:5b89748653464088807139d98b87ff49 2023-05-15T15:08:07+02:00 In vivo anti-salmonella activity of aqueous extract of Euphorbia prostrata Aiton (Euphorbiaceae) and its toxicological evaluation Donald Sédric Tala Donatien Gatsing Siméon Pierre Chegaing Fodouop Charles Fokunang Fabrice Kengni Merline Namekong Djimeli 2015-04-01T00:00:00Z https://doi.org/10.1016/S2221-1691(15)30350-6 https://doaj.org/article/5b89748653464088807139d98b87ff49 EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169115303506 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/S2221-1691(15)30350-6 https://doaj.org/article/5b89748653464088807139d98b87ff49 Asian Pacific Journal of Tropical Biomedicine, Vol 5, Iss 4, Pp 310-318 (2015) Euphorbia prostrata Ait Typhoid fever Salmonella Safety Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2015 ftdoajarticles https://doi.org/10.1016/S2221-1691(15)30350-6 2022-12-31T00:58:52Z Objective: To investigate the in vivo anti-salmonella activity and the safety of aqueous extract of Euphorbia prostratra (E. prostratra), a plant commonly used in Cameroon by traditional healers. Methods: A Salmonella typhimurium-infected rat model was used for the study. The physiological, biochemical and histopathological markers of possible side effects of this extract were studied using standard methods. Results: The extract had a significant effect on the number of viable Salmonella typhimurium recovered from faeces, and could stop salmonellosis after 8 and 10 days of treatment for male and female rats, respectively, with non-toxic doses. However, the biochemical and histopathological analyses revealed that at relatively high doses (≥ 73.48 mg/kg for female and ≥ 122.71 mg/kg for male) the extract could induce liver damage, as illustrated by a rise of serum transaminases’ levels and significant inflammation of the parenchyma and portal vein. Side effects were also observed on the kidneys, as shown by both serum and urinary creatinine, and urinary proteins. Conclusions: The overall results indicate that the aqueous extract of E. prostrata has the potential to provide an effective treatment for salmonellosis, including typhoid fever. However, it is necessary to extrapolate these results in large animals, in further studies. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 5 4 310 318 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Euphorbia prostrata Ait Typhoid fever Salmonella Safety Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
Euphorbia prostrata Ait Typhoid fever Salmonella Safety Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Donald Sédric Tala Donatien Gatsing Siméon Pierre Chegaing Fodouop Charles Fokunang Fabrice Kengni Merline Namekong Djimeli In vivo anti-salmonella activity of aqueous extract of Euphorbia prostrata Aiton (Euphorbiaceae) and its toxicological evaluation |
topic_facet |
Euphorbia prostrata Ait Typhoid fever Salmonella Safety Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To investigate the in vivo anti-salmonella activity and the safety of aqueous extract of Euphorbia prostratra (E. prostratra), a plant commonly used in Cameroon by traditional healers. Methods: A Salmonella typhimurium-infected rat model was used for the study. The physiological, biochemical and histopathological markers of possible side effects of this extract were studied using standard methods. Results: The extract had a significant effect on the number of viable Salmonella typhimurium recovered from faeces, and could stop salmonellosis after 8 and 10 days of treatment for male and female rats, respectively, with non-toxic doses. However, the biochemical and histopathological analyses revealed that at relatively high doses (≥ 73.48 mg/kg for female and ≥ 122.71 mg/kg for male) the extract could induce liver damage, as illustrated by a rise of serum transaminases’ levels and significant inflammation of the parenchyma and portal vein. Side effects were also observed on the kidneys, as shown by both serum and urinary creatinine, and urinary proteins. Conclusions: The overall results indicate that the aqueous extract of E. prostrata has the potential to provide an effective treatment for salmonellosis, including typhoid fever. However, it is necessary to extrapolate these results in large animals, in further studies. |
format |
Article in Journal/Newspaper |
author |
Donald Sédric Tala Donatien Gatsing Siméon Pierre Chegaing Fodouop Charles Fokunang Fabrice Kengni Merline Namekong Djimeli |
author_facet |
Donald Sédric Tala Donatien Gatsing Siméon Pierre Chegaing Fodouop Charles Fokunang Fabrice Kengni Merline Namekong Djimeli |
author_sort |
Donald Sédric Tala |
title |
In vivo anti-salmonella activity of aqueous extract of Euphorbia prostrata Aiton (Euphorbiaceae) and its toxicological evaluation |
title_short |
In vivo anti-salmonella activity of aqueous extract of Euphorbia prostrata Aiton (Euphorbiaceae) and its toxicological evaluation |
title_full |
In vivo anti-salmonella activity of aqueous extract of Euphorbia prostrata Aiton (Euphorbiaceae) and its toxicological evaluation |
title_fullStr |
In vivo anti-salmonella activity of aqueous extract of Euphorbia prostrata Aiton (Euphorbiaceae) and its toxicological evaluation |
title_full_unstemmed |
In vivo anti-salmonella activity of aqueous extract of Euphorbia prostrata Aiton (Euphorbiaceae) and its toxicological evaluation |
title_sort |
in vivo anti-salmonella activity of aqueous extract of euphorbia prostrata aiton (euphorbiaceae) and its toxicological evaluation |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2015 |
url |
https://doi.org/10.1016/S2221-1691(15)30350-6 https://doaj.org/article/5b89748653464088807139d98b87ff49 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 5, Iss 4, Pp 310-318 (2015) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169115303506 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/S2221-1691(15)30350-6 https://doaj.org/article/5b89748653464088807139d98b87ff49 |
op_doi |
https://doi.org/10.1016/S2221-1691(15)30350-6 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
5 |
container_issue |
4 |
container_start_page |
310 |
op_container_end_page |
318 |
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1766339534494105600 |