Annuloaortic ectasia in a dog: long-term follow-up and immunofluorescent study
A 4 month-old, 14.8 kg, male Newfoundland dog was presented for cardiovascular evaluation following detection of a heart murmur. Echocardiography revealed enlargement of the sinuses of Valsalva and marked, diffuse dilation of the ascending aorta (annuloaortic ectasia, AAE), with mild/equivocal subao...
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ftdoajarticles:oai:doaj.org/article:5b87751bb97b4986891377689f3f5552 2023-05-15T17:22:41+02:00 Annuloaortic ectasia in a dog: long-term follow-up and immunofluorescent study Etienne Côté Rong-Mo Zhang Nicole Kaiser Dieter P. Reinhardt Chelsea K. Martin 2021-12-01T00:00:00Z https://doi.org/10.1080/01652176.2021.1961039 https://doaj.org/article/5b87751bb97b4986891377689f3f5552 EN eng Taylor & Francis Group http://dx.doi.org/10.1080/01652176.2021.1961039 https://doaj.org/toc/0165-2176 https://doaj.org/toc/1875-5941 0165-2176 1875-5941 doi:10.1080/01652176.2021.1961039 https://doaj.org/article/5b87751bb97b4986891377689f3f5552 Veterinary Quarterly, Vol 41, Iss 1, Pp 280-291 (2021) canine aorta aneurysm subaortic stenosis marfan syndrome fibrillin-1 Veterinary medicine SF600-1100 article 2021 ftdoajarticles https://doi.org/10.1080/01652176.2021.1961039 2022-12-31T15:48:22Z A 4 month-old, 14.8 kg, male Newfoundland dog was presented for cardiovascular evaluation following detection of a heart murmur. Echocardiography revealed enlargement of the sinuses of Valsalva and marked, diffuse dilation of the ascending aorta (annuloaortic ectasia, AAE), with mild/equivocal subaortic stenosis (SAS). The dog was monitored over the duration of its lifetime, with serial echocardiograms performed at 5, 6, and 8 months and 1, 2, 3, 4, 8, and 10 years demonstrating persistent, diffuse dilation of the ascending aorta. The dog lived until it was 10 years old and died of metastatic carcinoma. Postmortem examination confirmed AAE and mild SAS. Hematoxylin and eosin and Weigert van Gieson stains were used to compare the ascending aorta to the descending aorta and left subclavian artery, and to compare aortic samples to those of three control dogs. Histopathologic evaluation revealed mild medial degeneration in the ascending aorta of all four dogs. Immunofluorescent microscopy was used for determining the deposition of proteins known to play a role in aortic aneurysms in humans: fibrillin-1 (FBN1), latent transforming growth factor beta binding protein 4 (LTBP4) and fibronectin. The ascending aorta of the AAE case demonstrated reduced deposition of FBN1, indicating that its loss may have contributed to aortic dilation. Diffuse, primary ascending aortic dilation is uncommonly reported in dogs; when it is, it carries a poor prognosis. This case provides an important example of marked dilation of the ascending aorta in a dog that lived with no associated adverse effects for 10 years. Article in Journal/Newspaper Newfoundland Directory of Open Access Journals: DOAJ Articles Veterinary Quarterly 41 1 280 291 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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topic |
canine aorta aneurysm subaortic stenosis marfan syndrome fibrillin-1 Veterinary medicine SF600-1100 |
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canine aorta aneurysm subaortic stenosis marfan syndrome fibrillin-1 Veterinary medicine SF600-1100 Etienne Côté Rong-Mo Zhang Nicole Kaiser Dieter P. Reinhardt Chelsea K. Martin Annuloaortic ectasia in a dog: long-term follow-up and immunofluorescent study |
topic_facet |
canine aorta aneurysm subaortic stenosis marfan syndrome fibrillin-1 Veterinary medicine SF600-1100 |
description |
A 4 month-old, 14.8 kg, male Newfoundland dog was presented for cardiovascular evaluation following detection of a heart murmur. Echocardiography revealed enlargement of the sinuses of Valsalva and marked, diffuse dilation of the ascending aorta (annuloaortic ectasia, AAE), with mild/equivocal subaortic stenosis (SAS). The dog was monitored over the duration of its lifetime, with serial echocardiograms performed at 5, 6, and 8 months and 1, 2, 3, 4, 8, and 10 years demonstrating persistent, diffuse dilation of the ascending aorta. The dog lived until it was 10 years old and died of metastatic carcinoma. Postmortem examination confirmed AAE and mild SAS. Hematoxylin and eosin and Weigert van Gieson stains were used to compare the ascending aorta to the descending aorta and left subclavian artery, and to compare aortic samples to those of three control dogs. Histopathologic evaluation revealed mild medial degeneration in the ascending aorta of all four dogs. Immunofluorescent microscopy was used for determining the deposition of proteins known to play a role in aortic aneurysms in humans: fibrillin-1 (FBN1), latent transforming growth factor beta binding protein 4 (LTBP4) and fibronectin. The ascending aorta of the AAE case demonstrated reduced deposition of FBN1, indicating that its loss may have contributed to aortic dilation. Diffuse, primary ascending aortic dilation is uncommonly reported in dogs; when it is, it carries a poor prognosis. This case provides an important example of marked dilation of the ascending aorta in a dog that lived with no associated adverse effects for 10 years. |
format |
Article in Journal/Newspaper |
author |
Etienne Côté Rong-Mo Zhang Nicole Kaiser Dieter P. Reinhardt Chelsea K. Martin |
author_facet |
Etienne Côté Rong-Mo Zhang Nicole Kaiser Dieter P. Reinhardt Chelsea K. Martin |
author_sort |
Etienne Côté |
title |
Annuloaortic ectasia in a dog: long-term follow-up and immunofluorescent study |
title_short |
Annuloaortic ectasia in a dog: long-term follow-up and immunofluorescent study |
title_full |
Annuloaortic ectasia in a dog: long-term follow-up and immunofluorescent study |
title_fullStr |
Annuloaortic ectasia in a dog: long-term follow-up and immunofluorescent study |
title_full_unstemmed |
Annuloaortic ectasia in a dog: long-term follow-up and immunofluorescent study |
title_sort |
annuloaortic ectasia in a dog: long-term follow-up and immunofluorescent study |
publisher |
Taylor & Francis Group |
publishDate |
2021 |
url |
https://doi.org/10.1080/01652176.2021.1961039 https://doaj.org/article/5b87751bb97b4986891377689f3f5552 |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_source |
Veterinary Quarterly, Vol 41, Iss 1, Pp 280-291 (2021) |
op_relation |
http://dx.doi.org/10.1080/01652176.2021.1961039 https://doaj.org/toc/0165-2176 https://doaj.org/toc/1875-5941 0165-2176 1875-5941 doi:10.1080/01652176.2021.1961039 https://doaj.org/article/5b87751bb97b4986891377689f3f5552 |
op_doi |
https://doi.org/10.1080/01652176.2021.1961039 |
container_title |
Veterinary Quarterly |
container_volume |
41 |
container_issue |
1 |
container_start_page |
280 |
op_container_end_page |
291 |
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