Health education through analogies: preparation of a community for clinical trials of a vaccine against hookworm in an endemic area of Brazil.
BACKGROUND: Obtaining informed consent for clinical trials is especially challenging when working in rural, resource-limited areas, where there are often high levels of illiteracy and lack of experience with clinical research. Such an area, a remote field site in the northeastern part of the state o...
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ftdoajarticles:oai:doaj.org/article:5b51d9750e804152bf5b5129cd660289 2023-05-15T15:17:32+02:00 Health education through analogies: preparation of a community for clinical trials of a vaccine against hookworm in an endemic area of Brazil. Maria Flavia Gazzinelli Lucas Lobato Leonardo Matoso Renato Avila Rita de Cassia Marques Ami Shah Brown Rodrigo Correa-Oliveira Jeffrey M Bethony David J Diemert 2010-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000749 https://doaj.org/article/5b51d9750e804152bf5b5129cd660289 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC2907418?pdf=render https://doaj.org/toc/1935-2735 1935-2735 doi:10.1371/journal.pntd.0000749 https://doaj.org/article/5b51d9750e804152bf5b5129cd660289 PLoS Neglected Tropical Diseases, Vol 4, Iss 7, p e749 (2010) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2010 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000749 2022-12-30T22:30:08Z BACKGROUND: Obtaining informed consent for clinical trials is especially challenging when working in rural, resource-limited areas, where there are often high levels of illiteracy and lack of experience with clinical research. Such an area, a remote field site in the northeastern part of the state of Minas Gerais, Brazil, is currently being prepared for clinical trials of experimental hookworm vaccines. This study was conducted to assess whether special educational tools can be developed to increase the knowledge and comprehension of potential clinical trial participants and thereby enable them to make truly informed decisions to participate in such research. METHODOLOGY/PRINCIPAL FINDINGS: An informational video was produced to explain the work of the research team and the first planned hookworm vaccine trial, using a pedagogical method based on analogies. Seventy-two adults living in a rural community of Minas Gerais were administered a structured questionnaire that assessed their knowledge of hookworm, of research and of the planned hookworm vaccine trial, as well as their attitudes and perceptions about the researchers and participation in future vaccine trials. The questionnaire was administered before being shown the educational video and two months after and the results compared. After viewing the video, significant improvements in knowledge related to hookworm infection and its health impact were observed: using a composite score combining related questions for which correct answers were assigned a value of 1 and incorrect answers a value of 0, participants had a mean score of 0.76 post-video compared to 0.68 pre-video (p = 0.0001). Similar improvements were seen in understanding the purpose of vaccination and the possible adverse effects of an experimental vaccine. Although 100% of participants expressed a positive opinion of the researchers even before viewing the film and over 90% said that they would participate in a hookworm vaccine trial, an increase in the number who expressed fear of being ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 4 7 e749 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Maria Flavia Gazzinelli Lucas Lobato Leonardo Matoso Renato Avila Rita de Cassia Marques Ami Shah Brown Rodrigo Correa-Oliveira Jeffrey M Bethony David J Diemert Health education through analogies: preparation of a community for clinical trials of a vaccine against hookworm in an endemic area of Brazil. |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND: Obtaining informed consent for clinical trials is especially challenging when working in rural, resource-limited areas, where there are often high levels of illiteracy and lack of experience with clinical research. Such an area, a remote field site in the northeastern part of the state of Minas Gerais, Brazil, is currently being prepared for clinical trials of experimental hookworm vaccines. This study was conducted to assess whether special educational tools can be developed to increase the knowledge and comprehension of potential clinical trial participants and thereby enable them to make truly informed decisions to participate in such research. METHODOLOGY/PRINCIPAL FINDINGS: An informational video was produced to explain the work of the research team and the first planned hookworm vaccine trial, using a pedagogical method based on analogies. Seventy-two adults living in a rural community of Minas Gerais were administered a structured questionnaire that assessed their knowledge of hookworm, of research and of the planned hookworm vaccine trial, as well as their attitudes and perceptions about the researchers and participation in future vaccine trials. The questionnaire was administered before being shown the educational video and two months after and the results compared. After viewing the video, significant improvements in knowledge related to hookworm infection and its health impact were observed: using a composite score combining related questions for which correct answers were assigned a value of 1 and incorrect answers a value of 0, participants had a mean score of 0.76 post-video compared to 0.68 pre-video (p = 0.0001). Similar improvements were seen in understanding the purpose of vaccination and the possible adverse effects of an experimental vaccine. Although 100% of participants expressed a positive opinion of the researchers even before viewing the film and over 90% said that they would participate in a hookworm vaccine trial, an increase in the number who expressed fear of being ... |
format |
Article in Journal/Newspaper |
author |
Maria Flavia Gazzinelli Lucas Lobato Leonardo Matoso Renato Avila Rita de Cassia Marques Ami Shah Brown Rodrigo Correa-Oliveira Jeffrey M Bethony David J Diemert |
author_facet |
Maria Flavia Gazzinelli Lucas Lobato Leonardo Matoso Renato Avila Rita de Cassia Marques Ami Shah Brown Rodrigo Correa-Oliveira Jeffrey M Bethony David J Diemert |
author_sort |
Maria Flavia Gazzinelli |
title |
Health education through analogies: preparation of a community for clinical trials of a vaccine against hookworm in an endemic area of Brazil. |
title_short |
Health education through analogies: preparation of a community for clinical trials of a vaccine against hookworm in an endemic area of Brazil. |
title_full |
Health education through analogies: preparation of a community for clinical trials of a vaccine against hookworm in an endemic area of Brazil. |
title_fullStr |
Health education through analogies: preparation of a community for clinical trials of a vaccine against hookworm in an endemic area of Brazil. |
title_full_unstemmed |
Health education through analogies: preparation of a community for clinical trials of a vaccine against hookworm in an endemic area of Brazil. |
title_sort |
health education through analogies: preparation of a community for clinical trials of a vaccine against hookworm in an endemic area of brazil. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2010 |
url |
https://doi.org/10.1371/journal.pntd.0000749 https://doaj.org/article/5b51d9750e804152bf5b5129cd660289 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 4, Iss 7, p e749 (2010) |
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http://europepmc.org/articles/PMC2907418?pdf=render https://doaj.org/toc/1935-2735 1935-2735 doi:10.1371/journal.pntd.0000749 https://doaj.org/article/5b51d9750e804152bf5b5129cd660289 |
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https://doi.org/10.1371/journal.pntd.0000749 |
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PLoS Neglected Tropical Diseases |
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