Evidence for Suppression of Onchocerciasis Transmission in Bioko Island, Equatorial Guinea.
Onchocerciasis or "river blindness" is a chronic parasitic neglected tropical disease which is endemic both in mainland and insular Equatorial Guinea. We aim to estimate the current epidemiological situation of onchocerciasis in Bioko Island after vector elimination in 2005 and more than s...
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ftdoajarticles:oai:doaj.org/article:5b23f81f14664a51969874ecc9efba3d 2023-05-15T15:16:52+02:00 Evidence for Suppression of Onchocerciasis Transmission in Bioko Island, Equatorial Guinea. Laura Moya Zaida Herrador Thuy Huong Ta-Tang Jose Miguel Rubio Maria Jesús Perteguer Ana Hernandez-González Belén García Rufino Nguema Justino Nguema Policarpo Ncogo Teresa Garate Agustín Benito Anacleto Sima Pilar Aparicio 2016-07-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0004829 https://doaj.org/article/5b23f81f14664a51969874ecc9efba3d EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4957785?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004829 https://doaj.org/article/5b23f81f14664a51969874ecc9efba3d PLoS Neglected Tropical Diseases, Vol 10, Iss 7, p e0004829 (2016) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2016 ftdoajarticles https://doi.org/10.1371/journal.pntd.0004829 2022-12-31T08:58:02Z Onchocerciasis or "river blindness" is a chronic parasitic neglected tropical disease which is endemic both in mainland and insular Equatorial Guinea. We aim to estimate the current epidemiological situation of onchocerciasis in Bioko Island after vector elimination in 2005 and more than sixteen years of Community Directed Treatment with Ivermectin (CDTI) by using molecular and serological approaches for onchocerciasis diagnosis. A community-based cross-sectional study was carried out in Bioko Island from mid-January to mid-February 2014. A total of 544 study participants were recruited. A complete dermatological examination was performed and three skin snips were performed in every participant for parasitological and molecular assessments. Blood spots were also taken for determination of Ov16 IgG4 antibodies trough an "in-house" ELISA assay. Overall, we found 15 out of 522 individuals suffering any onchocerciasis specific cutaneous lesions and 16 out of 528 (3.0%) with onchocercal nodules in the skin. Nodules were significantly associated with age, being more common in subjects older than 10 years than in younger people (3.9% vs. 0%, p = 0.029). Regarding the onchocerciasis laboratory assessment, no positive parasitological test for microfilaria detection was found in the skin snips. The calculated seroprevalence through IgG4 serology was 7.9%. No children less than 10 years old were found to be positive for this test. Only one case was positive for Onchocerca volvulus (O. volvulus) after skin PCR. The present study points out that the on-going mass ivermectin treatment has been effective in reducing the prevalence of onchocerciasis and corroborates the interruption of transmission in Bioko Island. To our knowledge, this is the first time that accurate information through molecular and serological techniques is generated to estimate the onchocerciasis prevalence in this zone. Sustained support from the national program and appropriate communication and health education strategies to reinforce participation in ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 10 7 e0004829 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Laura Moya Zaida Herrador Thuy Huong Ta-Tang Jose Miguel Rubio Maria Jesús Perteguer Ana Hernandez-González Belén García Rufino Nguema Justino Nguema Policarpo Ncogo Teresa Garate Agustín Benito Anacleto Sima Pilar Aparicio Evidence for Suppression of Onchocerciasis Transmission in Bioko Island, Equatorial Guinea. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Onchocerciasis or "river blindness" is a chronic parasitic neglected tropical disease which is endemic both in mainland and insular Equatorial Guinea. We aim to estimate the current epidemiological situation of onchocerciasis in Bioko Island after vector elimination in 2005 and more than sixteen years of Community Directed Treatment with Ivermectin (CDTI) by using molecular and serological approaches for onchocerciasis diagnosis. A community-based cross-sectional study was carried out in Bioko Island from mid-January to mid-February 2014. A total of 544 study participants were recruited. A complete dermatological examination was performed and three skin snips were performed in every participant for parasitological and molecular assessments. Blood spots were also taken for determination of Ov16 IgG4 antibodies trough an "in-house" ELISA assay. Overall, we found 15 out of 522 individuals suffering any onchocerciasis specific cutaneous lesions and 16 out of 528 (3.0%) with onchocercal nodules in the skin. Nodules were significantly associated with age, being more common in subjects older than 10 years than in younger people (3.9% vs. 0%, p = 0.029). Regarding the onchocerciasis laboratory assessment, no positive parasitological test for microfilaria detection was found in the skin snips. The calculated seroprevalence through IgG4 serology was 7.9%. No children less than 10 years old were found to be positive for this test. Only one case was positive for Onchocerca volvulus (O. volvulus) after skin PCR. The present study points out that the on-going mass ivermectin treatment has been effective in reducing the prevalence of onchocerciasis and corroborates the interruption of transmission in Bioko Island. To our knowledge, this is the first time that accurate information through molecular and serological techniques is generated to estimate the onchocerciasis prevalence in this zone. Sustained support from the national program and appropriate communication and health education strategies to reinforce participation in ... |
format |
Article in Journal/Newspaper |
author |
Laura Moya Zaida Herrador Thuy Huong Ta-Tang Jose Miguel Rubio Maria Jesús Perteguer Ana Hernandez-González Belén García Rufino Nguema Justino Nguema Policarpo Ncogo Teresa Garate Agustín Benito Anacleto Sima Pilar Aparicio |
author_facet |
Laura Moya Zaida Herrador Thuy Huong Ta-Tang Jose Miguel Rubio Maria Jesús Perteguer Ana Hernandez-González Belén García Rufino Nguema Justino Nguema Policarpo Ncogo Teresa Garate Agustín Benito Anacleto Sima Pilar Aparicio |
author_sort |
Laura Moya |
title |
Evidence for Suppression of Onchocerciasis Transmission in Bioko Island, Equatorial Guinea. |
title_short |
Evidence for Suppression of Onchocerciasis Transmission in Bioko Island, Equatorial Guinea. |
title_full |
Evidence for Suppression of Onchocerciasis Transmission in Bioko Island, Equatorial Guinea. |
title_fullStr |
Evidence for Suppression of Onchocerciasis Transmission in Bioko Island, Equatorial Guinea. |
title_full_unstemmed |
Evidence for Suppression of Onchocerciasis Transmission in Bioko Island, Equatorial Guinea. |
title_sort |
evidence for suppression of onchocerciasis transmission in bioko island, equatorial guinea. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pntd.0004829 https://doaj.org/article/5b23f81f14664a51969874ecc9efba3d |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 10, Iss 7, p e0004829 (2016) |
op_relation |
http://europepmc.org/articles/PMC4957785?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004829 https://doaj.org/article/5b23f81f14664a51969874ecc9efba3d |
op_doi |
https://doi.org/10.1371/journal.pntd.0004829 |
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PLOS Neglected Tropical Diseases |
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10 |
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7 |
container_start_page |
e0004829 |
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