Cases and distribution of visceral leishmaniasis in western São Paulo: A neglected disease in this region of Brazil.
Visceral leishmaniasis (VL) is one of the most prevalent parasitic diseases worldwide. In 2019, 97% of the total numbers of cases in Latin America were reported in Brazil. In São Paulo state, currently 17.6% of infected individuals live in the western region. To study this neglected disease on a reg...
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ftdoajarticles:oai:doaj.org/article:5b19825ece1b47bb82846c45e888a0c5 2023-05-15T15:16:19+02:00 Cases and distribution of visceral leishmaniasis in western São Paulo: A neglected disease in this region of Brazil. Regiane Soares Santana Karina Briguenti Souza Fernanda Lussari Elivelton Silva Fonseca Cristiane Oliveira Andrade Marcia Mitiko Kaihara Meidas Lourdes Aparecida Zampieri D'Andrea Francisco Assis Silva Edilson Ferreira Flores Ivete Rocha Anjolete Luiz Euribel Prestes-Carneiro 2021-06-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009411 https://doaj.org/article/5b19825ece1b47bb82846c45e888a0c5 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009411 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009411 https://doaj.org/article/5b19825ece1b47bb82846c45e888a0c5 PLoS Neglected Tropical Diseases, Vol 15, Iss 6, p e0009411 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009411 2022-12-31T11:11:01Z Visceral leishmaniasis (VL) is one of the most prevalent parasitic diseases worldwide. In 2019, 97% of the total numbers of cases in Latin America were reported in Brazil. In São Paulo state, currently 17.6% of infected individuals live in the western region. To study this neglected disease on a regional scale, we describe the spread of VL in 45 municipalities of the Regional Network for Health Assistance11(RNHA11). Environmental, human VL (HVL), and canine VL (CVL) cases, Human Development Index, and Lutzomyia longipalpis databases were obtained from public agencies. Global Moran's I index and local indicators of spatial association (LISA) statistics were used to identify spatial autocorrelation and to generate maps for the identification of VL clusters. On a local scale, we determined the spread of VL in the city of Teodoro Sampaio, part of the Pontal of Paranapanema. In Teodoro Sampaio, monthly peri-domicile sand fly collection; ELISA, IFAT and Rapid Test serological CVL; and ELISA HVL serum surveys were carried out. In RNHA11 from 2000 to 2018, Lu. longipalpis was found in 77.8%, CVL in 69%, and HVL in 42.2% of the 45 municipalities, and 537 individuals were notified with HVL. Dispersion occurred from the epicenter in the north to Teodoro Sampaio, in the south, where Lu. longipalpis and CVL were found in 2010, HVL in 2018, and critical hotspots of CVL were found in the periphery. Moran's Global Index showed a weak but statistically significant spatial autocorrelation related to cases of CVL (I = 0.2572), and 11 municipalities were identified as priority areas for implementing surveillance and control actions. In RNHA11, a complex array of socioeconomic and environmental factors may be fueling the epidemic and sustaining endemic transmission of VL, adding to the study of a neglected disease in a region of São Paulo, Brazil. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 15 6 e0009411 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Regiane Soares Santana Karina Briguenti Souza Fernanda Lussari Elivelton Silva Fonseca Cristiane Oliveira Andrade Marcia Mitiko Kaihara Meidas Lourdes Aparecida Zampieri D'Andrea Francisco Assis Silva Edilson Ferreira Flores Ivete Rocha Anjolete Luiz Euribel Prestes-Carneiro Cases and distribution of visceral leishmaniasis in western São Paulo: A neglected disease in this region of Brazil. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Visceral leishmaniasis (VL) is one of the most prevalent parasitic diseases worldwide. In 2019, 97% of the total numbers of cases in Latin America were reported in Brazil. In São Paulo state, currently 17.6% of infected individuals live in the western region. To study this neglected disease on a regional scale, we describe the spread of VL in 45 municipalities of the Regional Network for Health Assistance11(RNHA11). Environmental, human VL (HVL), and canine VL (CVL) cases, Human Development Index, and Lutzomyia longipalpis databases were obtained from public agencies. Global Moran's I index and local indicators of spatial association (LISA) statistics were used to identify spatial autocorrelation and to generate maps for the identification of VL clusters. On a local scale, we determined the spread of VL in the city of Teodoro Sampaio, part of the Pontal of Paranapanema. In Teodoro Sampaio, monthly peri-domicile sand fly collection; ELISA, IFAT and Rapid Test serological CVL; and ELISA HVL serum surveys were carried out. In RNHA11 from 2000 to 2018, Lu. longipalpis was found in 77.8%, CVL in 69%, and HVL in 42.2% of the 45 municipalities, and 537 individuals were notified with HVL. Dispersion occurred from the epicenter in the north to Teodoro Sampaio, in the south, where Lu. longipalpis and CVL were found in 2010, HVL in 2018, and critical hotspots of CVL were found in the periphery. Moran's Global Index showed a weak but statistically significant spatial autocorrelation related to cases of CVL (I = 0.2572), and 11 municipalities were identified as priority areas for implementing surveillance and control actions. In RNHA11, a complex array of socioeconomic and environmental factors may be fueling the epidemic and sustaining endemic transmission of VL, adding to the study of a neglected disease in a region of São Paulo, Brazil. |
format |
Article in Journal/Newspaper |
author |
Regiane Soares Santana Karina Briguenti Souza Fernanda Lussari Elivelton Silva Fonseca Cristiane Oliveira Andrade Marcia Mitiko Kaihara Meidas Lourdes Aparecida Zampieri D'Andrea Francisco Assis Silva Edilson Ferreira Flores Ivete Rocha Anjolete Luiz Euribel Prestes-Carneiro |
author_facet |
Regiane Soares Santana Karina Briguenti Souza Fernanda Lussari Elivelton Silva Fonseca Cristiane Oliveira Andrade Marcia Mitiko Kaihara Meidas Lourdes Aparecida Zampieri D'Andrea Francisco Assis Silva Edilson Ferreira Flores Ivete Rocha Anjolete Luiz Euribel Prestes-Carneiro |
author_sort |
Regiane Soares Santana |
title |
Cases and distribution of visceral leishmaniasis in western São Paulo: A neglected disease in this region of Brazil. |
title_short |
Cases and distribution of visceral leishmaniasis in western São Paulo: A neglected disease in this region of Brazil. |
title_full |
Cases and distribution of visceral leishmaniasis in western São Paulo: A neglected disease in this region of Brazil. |
title_fullStr |
Cases and distribution of visceral leishmaniasis in western São Paulo: A neglected disease in this region of Brazil. |
title_full_unstemmed |
Cases and distribution of visceral leishmaniasis in western São Paulo: A neglected disease in this region of Brazil. |
title_sort |
cases and distribution of visceral leishmaniasis in western são paulo: a neglected disease in this region of brazil. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009411 https://doaj.org/article/5b19825ece1b47bb82846c45e888a0c5 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 6, p e0009411 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009411 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009411 https://doaj.org/article/5b19825ece1b47bb82846c45e888a0c5 |
op_doi |
https://doi.org/10.1371/journal.pntd.0009411 |
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PLOS Neglected Tropical Diseases |
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15 |
container_issue |
6 |
container_start_page |
e0009411 |
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1766346611319898112 |