Egg excretion indicators for the measurement of soil-transmitted helminth response to treatment.
Background Periodic administration of anthelmintic drugs is a cost-effective intervention for morbidity control of soil-transmitted helminth (STH) infections. However, with programs expanding, drug pressure potentially selecting for drug-resistant parasites increases. While monitoring anthelmintic d...
Published in: | PLOS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2022
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0010593 https://doaj.org/article/5b1563a9a0d04c94b28795a04a7a6f83 |
id |
ftdoajarticles:oai:doaj.org/article:5b1563a9a0d04c94b28795a04a7a6f83 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:5b1563a9a0d04c94b28795a04a7a6f83 2023-05-15T15:14:32+02:00 Egg excretion indicators for the measurement of soil-transmitted helminth response to treatment. Piero L Olliaro Michel T Vaillant Aïssatou Diawara Benjamin Speich Marco Albonico Jürg Utzinger Jennifer Keiser 2022-08-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0010593 https://doaj.org/article/5b1563a9a0d04c94b28795a04a7a6f83 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0010593 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010593 https://doaj.org/article/5b1563a9a0d04c94b28795a04a7a6f83 PLoS Neglected Tropical Diseases, Vol 16, Iss 8, p e0010593 (2022) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2022 ftdoajarticles https://doi.org/10.1371/journal.pntd.0010593 2022-12-31T01:08:41Z Background Periodic administration of anthelmintic drugs is a cost-effective intervention for morbidity control of soil-transmitted helminth (STH) infections. However, with programs expanding, drug pressure potentially selecting for drug-resistant parasites increases. While monitoring anthelmintic drug efficacy is crucial to inform country control program strategies, different factors must be taken into consideration that influence drug efficacy and make it difficult to standardize treatment outcome measures. We aimed to identify suitable approaches to assess and compare the efficacy of different anthelmintic treatments. Methodology We built an individual participant-level database from 11 randomized controlled trials and two observational studies in which subjects received single-agent or combination therapy, or placebo. Eggs per gram of stool were calculated from egg counts at baseline and post-treatment. Egg reduction rates (ERR; based on mean group egg counts) and individual-patient ERR (iERR) were utilized to express drug efficacy and analyzed after log-transformation with a linear mixed effect model. The analyses were separated by follow-up duration (14-21 and 22-45 days) after drug administration. Principal findings The 13 studies enrolled 5,759 STH stool-positive individuals; 5,688 received active medication or placebo contributing a total of 11,103 STH infections (65% had two or three concurrent infections), of whom 3,904 (8,503 infections) and 1,784 (2,550 infections) had efficacy assessed at 14-21 days and 22-45 days post-treatment, respectively. Neither the number of helminth co-infections nor duration of follow-up affected ERR for any helminth species. The number of participants treated with single-dose albendazole was 689 (18%), with single-dose mebendazole 658 (17%), and with albendazole-based co-administrations 775 (23%). The overall mean ERR assessed by day 14-21 for albendazole and mebendazole was 94.5% and 87.4%, respectively on Ascaris lumbricoides, 86.8% and 40.8% on hookworm, and 44.9% and ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 16 8 e0010593 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Piero L Olliaro Michel T Vaillant Aïssatou Diawara Benjamin Speich Marco Albonico Jürg Utzinger Jennifer Keiser Egg excretion indicators for the measurement of soil-transmitted helminth response to treatment. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Periodic administration of anthelmintic drugs is a cost-effective intervention for morbidity control of soil-transmitted helminth (STH) infections. However, with programs expanding, drug pressure potentially selecting for drug-resistant parasites increases. While monitoring anthelmintic drug efficacy is crucial to inform country control program strategies, different factors must be taken into consideration that influence drug efficacy and make it difficult to standardize treatment outcome measures. We aimed to identify suitable approaches to assess and compare the efficacy of different anthelmintic treatments. Methodology We built an individual participant-level database from 11 randomized controlled trials and two observational studies in which subjects received single-agent or combination therapy, or placebo. Eggs per gram of stool were calculated from egg counts at baseline and post-treatment. Egg reduction rates (ERR; based on mean group egg counts) and individual-patient ERR (iERR) were utilized to express drug efficacy and analyzed after log-transformation with a linear mixed effect model. The analyses were separated by follow-up duration (14-21 and 22-45 days) after drug administration. Principal findings The 13 studies enrolled 5,759 STH stool-positive individuals; 5,688 received active medication or placebo contributing a total of 11,103 STH infections (65% had two or three concurrent infections), of whom 3,904 (8,503 infections) and 1,784 (2,550 infections) had efficacy assessed at 14-21 days and 22-45 days post-treatment, respectively. Neither the number of helminth co-infections nor duration of follow-up affected ERR for any helminth species. The number of participants treated with single-dose albendazole was 689 (18%), with single-dose mebendazole 658 (17%), and with albendazole-based co-administrations 775 (23%). The overall mean ERR assessed by day 14-21 for albendazole and mebendazole was 94.5% and 87.4%, respectively on Ascaris lumbricoides, 86.8% and 40.8% on hookworm, and 44.9% and ... |
format |
Article in Journal/Newspaper |
author |
Piero L Olliaro Michel T Vaillant Aïssatou Diawara Benjamin Speich Marco Albonico Jürg Utzinger Jennifer Keiser |
author_facet |
Piero L Olliaro Michel T Vaillant Aïssatou Diawara Benjamin Speich Marco Albonico Jürg Utzinger Jennifer Keiser |
author_sort |
Piero L Olliaro |
title |
Egg excretion indicators for the measurement of soil-transmitted helminth response to treatment. |
title_short |
Egg excretion indicators for the measurement of soil-transmitted helminth response to treatment. |
title_full |
Egg excretion indicators for the measurement of soil-transmitted helminth response to treatment. |
title_fullStr |
Egg excretion indicators for the measurement of soil-transmitted helminth response to treatment. |
title_full_unstemmed |
Egg excretion indicators for the measurement of soil-transmitted helminth response to treatment. |
title_sort |
egg excretion indicators for the measurement of soil-transmitted helminth response to treatment. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2022 |
url |
https://doi.org/10.1371/journal.pntd.0010593 https://doaj.org/article/5b1563a9a0d04c94b28795a04a7a6f83 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 16, Iss 8, p e0010593 (2022) |
op_relation |
https://doi.org/10.1371/journal.pntd.0010593 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010593 https://doaj.org/article/5b1563a9a0d04c94b28795a04a7a6f83 |
op_doi |
https://doi.org/10.1371/journal.pntd.0010593 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
16 |
container_issue |
8 |
container_start_page |
e0010593 |
_version_ |
1766344980864958464 |