High incidence of hypertriglyceridemia in a Brazilian cohort of people living with HIV/AIDS undergoing antiretroviral treatment in Belo Horizonte, 2001-2010

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Cássia Cristina Pinto Mendicino, Letícia Pena Braga, Cristiane Aparecida Menezes de Pádua, Mark Drew Crosland Guimarães
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT)
• Subjects: HIV/AIDS; Hypertriglyceridemia; ART; Arctic medicine. Tropical medicine; RC955-962; Arctic; Meier
• Online Access: https://doi.org/10.1590/0037-8682-0078-2016; https://doaj.org/article/5acc75f06f314ded849507b586628422

Abstract INTRODUCTION: Hypertriglyceridemia incidence should be estimated in HIV-infected patients after antiretroviral therapy (ART) initiation. METHODS: We retrospectively analyzed clinical data of HIV-infected adults at 3 public referral centers. Cumulative and person-time incidences were estimated for patients without hypertriglyceridemia. Survival time and hazard ratio (HR) were estimated by Kaplan-Meier analysis and Cox proportional regression, respectively. RESULTS: Cumulative and person-time incidences were 40.4% and 1.4 cases/100 person-months, respectively. The median period for hypertriglyceridemia occurrence was 47 months. Men and patients with switched ART regimens had increased hypertriglyceridemia risk (HR=3.05 and 3.34, respectively). CONCLUSIONS: Hypertriglyceridemia incidence is high in HIV-infected patients undergoing ART.