Rapid change in the ciprofloxacin resistance pattern among Neisseria gonorrhoeae strains in Nuuk, Greenland: time to reconsider preventive and treatment strategies
Objectives: Sexually transmitted infections (STIs), including infections with Neisseria gonorrhoeae (GC), are highly incident in Greenland. Since January 2011, GC testing has been performed on urine with nucleic acid amplification tests (NAATs) by strand displacement amplification (Becton Dickinson...
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2015
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ftdoajarticles:oai:doaj.org/article:5aa8c5370a5f4de69e4967e524f4b419 2023-05-15T15:15:24+02:00 Rapid change in the ciprofloxacin resistance pattern among Neisseria gonorrhoeae strains in Nuuk, Greenland: time to reconsider preventive and treatment strategies Anne Skjerbæk Rolskov Karen Bjorn-Mortensen Gert Mulvad Peter Poulsen Jørgen Skov Jensen Michael Lynge Pedersen 2015-05-01T00:00:00Z https://doi.org/10.3402/ijch.v74.26916 https://doaj.org/article/5aa8c5370a5f4de69e4967e524f4b419 EN eng Taylor & Francis Group http://www.circumpolarhealthjournal.net/index.php/ijch/article/view/26916/pdf_19 https://doaj.org/toc/2242-3982 2242-3982 doi:10.3402/ijch.v74.26916 https://doaj.org/article/5aa8c5370a5f4de69e4967e524f4b419 International Journal of Circumpolar Health, Vol 74, Iss 0, Pp 1-3 (2015) Neisseria gonorrhoeae sexually transmitted infections antimicrobial resistance ciprofloxacin resistance Arctic medicine. Tropical medicine RC955-962 article 2015 ftdoajarticles https://doi.org/10.3402/ijch.v74.26916 2022-12-31T06:18:56Z Objectives: Sexually transmitted infections (STIs), including infections with Neisseria gonorrhoeae (GC), are highly incident in Greenland. Since January 2011, GC testing has been performed on urine with nucleic acid amplification tests (NAATs) by strand displacement amplification (Becton Dickinson ProbeTec). Monitoring of GC antibiotic susceptibility by culture was introduced in Nuuk in 2012. Until 2014, no cases of ciprofloxacin-resistant GC strains were reported. In this paper, we report the finding of ciprofloxacin-resistant GC and describe the most recent incidence of GC infections in Greenland. Methods: The number of urine NAATs and culture-positive swabs from January to October 2014 were obtained from the Central Laboratory at Queens Ingrid's Hospital in Nuuk and stratified on gender, place and period of testing. Incidence rates were estimated as number of urine NAAT * (12/10) per 100,000 inhabitants. Men in Nuuk with a positive NAAT for GC were encouraged to provide a urethral swab for culture and susceptibility testing. Results: From January to October 2014, a total of 5,436 urine GC NAATs were performed on patients from Nuuk and 9,031 from the rest of Greenland. Of these, 422 (8%) and 820 (9%) were positive, respectively. From January to August, 6 (15%) cultures from Nuuk were ciprofloxacin resistant while in September and October, 26 (59%) were ciprofloxacin resistant (p<0.01). In total, 35 (40%) of 88 culture-positive isolates showed ciprofloxacin resistance. GC incidence in Nuuk was 3,017 per 100,000 inhabitants per year, compared to 2,491 per 100,000 inhabitants per year in the rest of Greenland. Conclusion: Within a short period, a rapid and dramatic change in ciprofloxacin susceptibility among GC strains isolated in Nuuk was documented and recommendation for first line treatments has changed. Continued monitoring and rethinking of primary and secondary preventive initiatives is highly recommended in this high GC incidence setting. Article in Journal/Newspaper Arctic Circumpolar Health Greenland International Journal of Circumpolar Health Nuuk Directory of Open Access Journals: DOAJ Articles Arctic Greenland Nuuk ENVELOPE(-52.150,-52.150,68.717,68.717) International Journal of Circumpolar Health 74 1 26916 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Neisseria gonorrhoeae sexually transmitted infections antimicrobial resistance ciprofloxacin resistance Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Neisseria gonorrhoeae sexually transmitted infections antimicrobial resistance ciprofloxacin resistance Arctic medicine. Tropical medicine RC955-962 Anne Skjerbæk Rolskov Karen Bjorn-Mortensen Gert Mulvad Peter Poulsen Jørgen Skov Jensen Michael Lynge Pedersen Rapid change in the ciprofloxacin resistance pattern among Neisseria gonorrhoeae strains in Nuuk, Greenland: time to reconsider preventive and treatment strategies |
topic_facet |
Neisseria gonorrhoeae sexually transmitted infections antimicrobial resistance ciprofloxacin resistance Arctic medicine. Tropical medicine RC955-962 |
description |
Objectives: Sexually transmitted infections (STIs), including infections with Neisseria gonorrhoeae (GC), are highly incident in Greenland. Since January 2011, GC testing has been performed on urine with nucleic acid amplification tests (NAATs) by strand displacement amplification (Becton Dickinson ProbeTec). Monitoring of GC antibiotic susceptibility by culture was introduced in Nuuk in 2012. Until 2014, no cases of ciprofloxacin-resistant GC strains were reported. In this paper, we report the finding of ciprofloxacin-resistant GC and describe the most recent incidence of GC infections in Greenland. Methods: The number of urine NAATs and culture-positive swabs from January to October 2014 were obtained from the Central Laboratory at Queens Ingrid's Hospital in Nuuk and stratified on gender, place and period of testing. Incidence rates were estimated as number of urine NAAT * (12/10) per 100,000 inhabitants. Men in Nuuk with a positive NAAT for GC were encouraged to provide a urethral swab for culture and susceptibility testing. Results: From January to October 2014, a total of 5,436 urine GC NAATs were performed on patients from Nuuk and 9,031 from the rest of Greenland. Of these, 422 (8%) and 820 (9%) were positive, respectively. From January to August, 6 (15%) cultures from Nuuk were ciprofloxacin resistant while in September and October, 26 (59%) were ciprofloxacin resistant (p<0.01). In total, 35 (40%) of 88 culture-positive isolates showed ciprofloxacin resistance. GC incidence in Nuuk was 3,017 per 100,000 inhabitants per year, compared to 2,491 per 100,000 inhabitants per year in the rest of Greenland. Conclusion: Within a short period, a rapid and dramatic change in ciprofloxacin susceptibility among GC strains isolated in Nuuk was documented and recommendation for first line treatments has changed. Continued monitoring and rethinking of primary and secondary preventive initiatives is highly recommended in this high GC incidence setting. |
format |
Article in Journal/Newspaper |
author |
Anne Skjerbæk Rolskov Karen Bjorn-Mortensen Gert Mulvad Peter Poulsen Jørgen Skov Jensen Michael Lynge Pedersen |
author_facet |
Anne Skjerbæk Rolskov Karen Bjorn-Mortensen Gert Mulvad Peter Poulsen Jørgen Skov Jensen Michael Lynge Pedersen |
author_sort |
Anne Skjerbæk Rolskov |
title |
Rapid change in the ciprofloxacin resistance pattern among Neisseria gonorrhoeae strains in Nuuk, Greenland: time to reconsider preventive and treatment strategies |
title_short |
Rapid change in the ciprofloxacin resistance pattern among Neisseria gonorrhoeae strains in Nuuk, Greenland: time to reconsider preventive and treatment strategies |
title_full |
Rapid change in the ciprofloxacin resistance pattern among Neisseria gonorrhoeae strains in Nuuk, Greenland: time to reconsider preventive and treatment strategies |
title_fullStr |
Rapid change in the ciprofloxacin resistance pattern among Neisseria gonorrhoeae strains in Nuuk, Greenland: time to reconsider preventive and treatment strategies |
title_full_unstemmed |
Rapid change in the ciprofloxacin resistance pattern among Neisseria gonorrhoeae strains in Nuuk, Greenland: time to reconsider preventive and treatment strategies |
title_sort |
rapid change in the ciprofloxacin resistance pattern among neisseria gonorrhoeae strains in nuuk, greenland: time to reconsider preventive and treatment strategies |
publisher |
Taylor & Francis Group |
publishDate |
2015 |
url |
https://doi.org/10.3402/ijch.v74.26916 https://doaj.org/article/5aa8c5370a5f4de69e4967e524f4b419 |
long_lat |
ENVELOPE(-52.150,-52.150,68.717,68.717) |
geographic |
Arctic Greenland Nuuk |
geographic_facet |
Arctic Greenland Nuuk |
genre |
Arctic Circumpolar Health Greenland International Journal of Circumpolar Health Nuuk |
genre_facet |
Arctic Circumpolar Health Greenland International Journal of Circumpolar Health Nuuk |
op_source |
International Journal of Circumpolar Health, Vol 74, Iss 0, Pp 1-3 (2015) |
op_relation |
http://www.circumpolarhealthjournal.net/index.php/ijch/article/view/26916/pdf_19 https://doaj.org/toc/2242-3982 2242-3982 doi:10.3402/ijch.v74.26916 https://doaj.org/article/5aa8c5370a5f4de69e4967e524f4b419 |
op_doi |
https://doi.org/10.3402/ijch.v74.26916 |
container_title |
International Journal of Circumpolar Health |
container_volume |
74 |
container_issue |
1 |
container_start_page |
26916 |
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1766345770179493888 |