A review of preventative methods against human leishmaniasis infection.
Leishmaniasis is an intracellular parasitic infection transmitted to humans via the sandfly. Approximately 350 million people are at risk of contracting the disease and an estimated 1.6 million new cases occur annually. Of the two main forms, visceral and cutaneous, the visceral form is fatal in 85-...
Published in: | PLoS Neglected Tropical Diseases |
---|---|
Main Authors: | , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0002278 https://doaj.org/article/5aa262551e9b454f87c8cb768a666e5f |
id |
ftdoajarticles:oai:doaj.org/article:5aa262551e9b454f87c8cb768a666e5f |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:5aa262551e9b454f87c8cb768a666e5f 2023-05-15T15:08:45+02:00 A review of preventative methods against human leishmaniasis infection. Lisa Stockdale Robert Newton 2013-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0002278 https://doaj.org/article/5aa262551e9b454f87c8cb768a666e5f EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3688540?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002278 https://doaj.org/article/5aa262551e9b454f87c8cb768a666e5f PLoS Neglected Tropical Diseases, Vol 7, Iss 6, p e2278 (2013) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2013 ftdoajarticles https://doi.org/10.1371/journal.pntd.0002278 2022-12-31T06:05:41Z Leishmaniasis is an intracellular parasitic infection transmitted to humans via the sandfly. Approximately 350 million people are at risk of contracting the disease and an estimated 1.6 million new cases occur annually. Of the two main forms, visceral and cutaneous, the visceral form is fatal in 85-90% of untreated cases.This literature review aims to identify and evaluate the current evidence base for the use of various preventative methods against human leishmaniasis.A literature search was performed of the relevant database repositories for primary research conforming to a priori inclusion and exclusion criteria.A total of 84 controlled studies investigating 12 outcome measures were identified, implementing four broad categories of preventative interventions: animal reservoir control, vector population control, human reservoir control and a category for multiple concurrently implemented interventions. The primary studies investigated a heterogeneous mix of outcome measures using a range of different methods.This review highlights an absence of research measuring human-specific outcomes (35% of the total) across all intervention categories. The apparent inability of study findings to be generalizable across different geographic locations, points towards gaps in knowledge regarding the biology of transmission of Leishmania in different settings. More research is needed which investigates human infection as the primary outcome measure as opposed to intermediate surrogate markers, with a focus on developing a human vaccine. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 7 6 e2278 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Lisa Stockdale Robert Newton A review of preventative methods against human leishmaniasis infection. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Leishmaniasis is an intracellular parasitic infection transmitted to humans via the sandfly. Approximately 350 million people are at risk of contracting the disease and an estimated 1.6 million new cases occur annually. Of the two main forms, visceral and cutaneous, the visceral form is fatal in 85-90% of untreated cases.This literature review aims to identify and evaluate the current evidence base for the use of various preventative methods against human leishmaniasis.A literature search was performed of the relevant database repositories for primary research conforming to a priori inclusion and exclusion criteria.A total of 84 controlled studies investigating 12 outcome measures were identified, implementing four broad categories of preventative interventions: animal reservoir control, vector population control, human reservoir control and a category for multiple concurrently implemented interventions. The primary studies investigated a heterogeneous mix of outcome measures using a range of different methods.This review highlights an absence of research measuring human-specific outcomes (35% of the total) across all intervention categories. The apparent inability of study findings to be generalizable across different geographic locations, points towards gaps in knowledge regarding the biology of transmission of Leishmania in different settings. More research is needed which investigates human infection as the primary outcome measure as opposed to intermediate surrogate markers, with a focus on developing a human vaccine. |
format |
Article in Journal/Newspaper |
author |
Lisa Stockdale Robert Newton |
author_facet |
Lisa Stockdale Robert Newton |
author_sort |
Lisa Stockdale |
title |
A review of preventative methods against human leishmaniasis infection. |
title_short |
A review of preventative methods against human leishmaniasis infection. |
title_full |
A review of preventative methods against human leishmaniasis infection. |
title_fullStr |
A review of preventative methods against human leishmaniasis infection. |
title_full_unstemmed |
A review of preventative methods against human leishmaniasis infection. |
title_sort |
review of preventative methods against human leishmaniasis infection. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2013 |
url |
https://doi.org/10.1371/journal.pntd.0002278 https://doaj.org/article/5aa262551e9b454f87c8cb768a666e5f |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 7, Iss 6, p e2278 (2013) |
op_relation |
http://europepmc.org/articles/PMC3688540?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002278 https://doaj.org/article/5aa262551e9b454f87c8cb768a666e5f |
op_doi |
https://doi.org/10.1371/journal.pntd.0002278 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
7 |
container_issue |
6 |
container_start_page |
e2278 |
_version_ |
1766340052699316224 |