Heart and skeletal muscle inflammation of farmed salmon is associated with infection with a novel reovirus.
Atlantic salmon (Salmo salar L.) mariculture has been associated with epidemics of infectious diseases that threaten not only local production, but also wild fish coming into close proximity to marine pens and fish escaping from them. Heart and skeletal muscle inflammation (HSMI) is a frequently fat...
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ftdoajarticles:oai:doaj.org/article:5a7e1af2bf7547a6abd543f41f095213 2023-05-15T15:31:24+02:00 Heart and skeletal muscle inflammation of farmed salmon is associated with infection with a novel reovirus. Gustavo Palacios Marie Lovoll Torstein Tengs Mady Hornig Stephen Hutchison Jeffrey Hui Ruth-Torill Kongtorp Nazir Savji Ana V Bussetti Alexander Solovyov Anja B Kristoffersen Christopher Celone Craig Street Vladimir Trifonov David L Hirschberg Raul Rabadan Michael Egholm Espen Rimstad W Ian Lipkin 2010-07-01T00:00:00Z https://doi.org/10.1371/journal.pone.0011487 https://doaj.org/article/5a7e1af2bf7547a6abd543f41f095213 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC2901333?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0011487 https://doaj.org/article/5a7e1af2bf7547a6abd543f41f095213 PLoS ONE, Vol 5, Iss 7, p e11487 (2010) Medicine R Science Q article 2010 ftdoajarticles https://doi.org/10.1371/journal.pone.0011487 2022-12-31T00:04:23Z Atlantic salmon (Salmo salar L.) mariculture has been associated with epidemics of infectious diseases that threaten not only local production, but also wild fish coming into close proximity to marine pens and fish escaping from them. Heart and skeletal muscle inflammation (HSMI) is a frequently fatal disease of farmed Atlantic salmon. First recognized in one farm in Norway in 1999, HSMI was subsequently implicated in outbreaks in other farms in Norway and the United Kingdom. Although pathology and disease transmission studies indicated an infectious basis, efforts to identify an agent were unsuccessful. Here we provide evidence that HSMI is associated with infection with piscine reovirus (PRV). PRV is a novel reovirus identified by unbiased high throughput DNA sequencing and a bioinformatics program focused on nucleotide frequency as well as sequence alignment and motif analyses. Formal implication of PRV in HSMI will require isolation in cell culture and fulfillment of Koch's postulates, or prevention or modification of disease through use of specific drugs or vaccines. Nonetheless, as our data indicate that a causal relationship is plausible, measures must be taken to control PRV not only because it threatens domestic salmon production but also due to the potential for transmission to wild salmon populations. Article in Journal/Newspaper Atlantic salmon Salmo salar Directory of Open Access Journals: DOAJ Articles Norway PLoS ONE 5 7 e11487 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Medicine R Science Q |
spellingShingle |
Medicine R Science Q Gustavo Palacios Marie Lovoll Torstein Tengs Mady Hornig Stephen Hutchison Jeffrey Hui Ruth-Torill Kongtorp Nazir Savji Ana V Bussetti Alexander Solovyov Anja B Kristoffersen Christopher Celone Craig Street Vladimir Trifonov David L Hirschberg Raul Rabadan Michael Egholm Espen Rimstad W Ian Lipkin Heart and skeletal muscle inflammation of farmed salmon is associated with infection with a novel reovirus. |
topic_facet |
Medicine R Science Q |
description |
Atlantic salmon (Salmo salar L.) mariculture has been associated with epidemics of infectious diseases that threaten not only local production, but also wild fish coming into close proximity to marine pens and fish escaping from them. Heart and skeletal muscle inflammation (HSMI) is a frequently fatal disease of farmed Atlantic salmon. First recognized in one farm in Norway in 1999, HSMI was subsequently implicated in outbreaks in other farms in Norway and the United Kingdom. Although pathology and disease transmission studies indicated an infectious basis, efforts to identify an agent were unsuccessful. Here we provide evidence that HSMI is associated with infection with piscine reovirus (PRV). PRV is a novel reovirus identified by unbiased high throughput DNA sequencing and a bioinformatics program focused on nucleotide frequency as well as sequence alignment and motif analyses. Formal implication of PRV in HSMI will require isolation in cell culture and fulfillment of Koch's postulates, or prevention or modification of disease through use of specific drugs or vaccines. Nonetheless, as our data indicate that a causal relationship is plausible, measures must be taken to control PRV not only because it threatens domestic salmon production but also due to the potential for transmission to wild salmon populations. |
format |
Article in Journal/Newspaper |
author |
Gustavo Palacios Marie Lovoll Torstein Tengs Mady Hornig Stephen Hutchison Jeffrey Hui Ruth-Torill Kongtorp Nazir Savji Ana V Bussetti Alexander Solovyov Anja B Kristoffersen Christopher Celone Craig Street Vladimir Trifonov David L Hirschberg Raul Rabadan Michael Egholm Espen Rimstad W Ian Lipkin |
author_facet |
Gustavo Palacios Marie Lovoll Torstein Tengs Mady Hornig Stephen Hutchison Jeffrey Hui Ruth-Torill Kongtorp Nazir Savji Ana V Bussetti Alexander Solovyov Anja B Kristoffersen Christopher Celone Craig Street Vladimir Trifonov David L Hirschberg Raul Rabadan Michael Egholm Espen Rimstad W Ian Lipkin |
author_sort |
Gustavo Palacios |
title |
Heart and skeletal muscle inflammation of farmed salmon is associated with infection with a novel reovirus. |
title_short |
Heart and skeletal muscle inflammation of farmed salmon is associated with infection with a novel reovirus. |
title_full |
Heart and skeletal muscle inflammation of farmed salmon is associated with infection with a novel reovirus. |
title_fullStr |
Heart and skeletal muscle inflammation of farmed salmon is associated with infection with a novel reovirus. |
title_full_unstemmed |
Heart and skeletal muscle inflammation of farmed salmon is associated with infection with a novel reovirus. |
title_sort |
heart and skeletal muscle inflammation of farmed salmon is associated with infection with a novel reovirus. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2010 |
url |
https://doi.org/10.1371/journal.pone.0011487 https://doaj.org/article/5a7e1af2bf7547a6abd543f41f095213 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
PLoS ONE, Vol 5, Iss 7, p e11487 (2010) |
op_relation |
http://europepmc.org/articles/PMC2901333?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0011487 https://doaj.org/article/5a7e1af2bf7547a6abd543f41f095213 |
op_doi |
https://doi.org/10.1371/journal.pone.0011487 |
container_title |
PLoS ONE |
container_volume |
5 |
container_issue |
7 |
container_start_page |
e11487 |
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1766361900539445248 |