The effect of a dialyzable transfer factor (TFd) in the experimental american trypanosomiasis of mice: preliminary report

• Main Author: Humberto Menezes
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 1977
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doaj.org/article/5a5a21f69d1f4524aff30512feb2543b

A dialyzable transfer factor (TFd) was obtained from spleen cells, of mice vaccinated with the avirulent PF strain of Trypanosoma cruzi. This factor reduced significahtly the parasitemia of animals treated before or after the infection with a virulent strain of the same parasite, but does not reduced the mortality rate to a level lower than that of the control mice. It is expected that in a next future, new techniques in the use ofsuch factor will bring better resutts. Um fator dialisavel capaz de transferir a imunidade de células sensibilizadas foi obtido de camundongos vacinados com a cepa PF. Este fator foi capaz de reduzir significantemente a parasitemia de animais previamente tratados com o mesmo e depois infectados ou de camundongos infectados inicialmente e depois tratados. Os resultados foram considerados pobres com respeito a mortalidade dos tratados, mas não dcsencorajadores, esperando-se melhores conclusões no futuro.