EGF-mediated EGFR/ERK signaling pathway promotes germinative cell proliferation in Echinococcus multilocularis that contributes to larval growth and development.

• Published in: PLOS Neglected Tropical Diseases
• Main Authors: Zhe Cheng, Fan Liu, Xiu Li, Mengya Dai, Jianjian Wu, Xinrui Guo, Huimin Tian, Zhijie Heng, Ying Lu, Xiaoli Chai, Yanhai Wang
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2017
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; Mek
• Online Access: https://doi.org/10.1371/journal.pntd.0005418; https://doaj.org/article/5a3e8954b4754c52bcec2e972b22c1da

BACKGROUND:Larvae of the tapeworm E. multilocularis cause alveolar echinococcosis (AE), one of the most lethal helminthic infections in humans. A population of stem cell-like cells, the germinative cells, is considered to drive the larval growth and development within the host. The molecular mechani...