EGF-mediated EGFR/ERK signaling pathway promotes germinative cell proliferation in Echinococcus multilocularis that contributes to larval growth and development.
BACKGROUND:Larvae of the tapeworm E. multilocularis cause alveolar echinococcosis (AE), one of the most lethal helminthic infections in humans. A population of stem cell-like cells, the germinative cells, is considered to drive the larval growth and development within the host. The molecular mechani...
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Online Access: | https://doi.org/10.1371/journal.pntd.0005418 https://doaj.org/article/5a3e8954b4754c52bcec2e972b22c1da |
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ftdoajarticles:oai:doaj.org/article:5a3e8954b4754c52bcec2e972b22c1da 2023-05-15T15:05:30+02:00 EGF-mediated EGFR/ERK signaling pathway promotes germinative cell proliferation in Echinococcus multilocularis that contributes to larval growth and development. Zhe Cheng Fan Liu Xiu Li Mengya Dai Jianjian Wu Xinrui Guo Huimin Tian Zhijie Heng Ying Lu Xiaoli Chai Yanhai Wang 2017-02-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005418 https://doaj.org/article/5a3e8954b4754c52bcec2e972b22c1da EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5344531?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005418 https://doaj.org/article/5a3e8954b4754c52bcec2e972b22c1da PLoS Neglected Tropical Diseases, Vol 11, Iss 2, p e0005418 (2017) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2017 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005418 2022-12-31T12:31:56Z BACKGROUND:Larvae of the tapeworm E. multilocularis cause alveolar echinococcosis (AE), one of the most lethal helminthic infections in humans. A population of stem cell-like cells, the germinative cells, is considered to drive the larval growth and development within the host. The molecular mechanisms controlling the behavior of germinative cells are largely unknown. METHODOLOGY/PRINCIPAL FINDINGS:Using in vitro cultivation systems we show here that the EGFR/ERK signaling in the parasite can promote germinative cell proliferation in response to addition of human EGF, resulting in stimulated growth and development of the metacestode larvae. Inhibition of the signaling by either the EGFR inhibitors CI-1033 and BIBW2992 or the MEK/ERK inhibitor U0126 impairs germinative cell proliferation and larval growth. CONCLUSIONS/SIGNIFICANCE:These data demonstrate the contribution of EGF-mediated EGFR/ERK signaling to the regulation of germinative cells in E. multilocularis, and suggest the EGFR/ERK signaling as a potential therapeutic target for AE and perhaps other human cestodiasis. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Mek ENVELOPE(7.086,7.086,62.735,62.735) PLOS Neglected Tropical Diseases 11 2 e0005418 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Zhe Cheng Fan Liu Xiu Li Mengya Dai Jianjian Wu Xinrui Guo Huimin Tian Zhijie Heng Ying Lu Xiaoli Chai Yanhai Wang EGF-mediated EGFR/ERK signaling pathway promotes germinative cell proliferation in Echinococcus multilocularis that contributes to larval growth and development. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:Larvae of the tapeworm E. multilocularis cause alveolar echinococcosis (AE), one of the most lethal helminthic infections in humans. A population of stem cell-like cells, the germinative cells, is considered to drive the larval growth and development within the host. The molecular mechanisms controlling the behavior of germinative cells are largely unknown. METHODOLOGY/PRINCIPAL FINDINGS:Using in vitro cultivation systems we show here that the EGFR/ERK signaling in the parasite can promote germinative cell proliferation in response to addition of human EGF, resulting in stimulated growth and development of the metacestode larvae. Inhibition of the signaling by either the EGFR inhibitors CI-1033 and BIBW2992 or the MEK/ERK inhibitor U0126 impairs germinative cell proliferation and larval growth. CONCLUSIONS/SIGNIFICANCE:These data demonstrate the contribution of EGF-mediated EGFR/ERK signaling to the regulation of germinative cells in E. multilocularis, and suggest the EGFR/ERK signaling as a potential therapeutic target for AE and perhaps other human cestodiasis. |
format |
Article in Journal/Newspaper |
author |
Zhe Cheng Fan Liu Xiu Li Mengya Dai Jianjian Wu Xinrui Guo Huimin Tian Zhijie Heng Ying Lu Xiaoli Chai Yanhai Wang |
author_facet |
Zhe Cheng Fan Liu Xiu Li Mengya Dai Jianjian Wu Xinrui Guo Huimin Tian Zhijie Heng Ying Lu Xiaoli Chai Yanhai Wang |
author_sort |
Zhe Cheng |
title |
EGF-mediated EGFR/ERK signaling pathway promotes germinative cell proliferation in Echinococcus multilocularis that contributes to larval growth and development. |
title_short |
EGF-mediated EGFR/ERK signaling pathway promotes germinative cell proliferation in Echinococcus multilocularis that contributes to larval growth and development. |
title_full |
EGF-mediated EGFR/ERK signaling pathway promotes germinative cell proliferation in Echinococcus multilocularis that contributes to larval growth and development. |
title_fullStr |
EGF-mediated EGFR/ERK signaling pathway promotes germinative cell proliferation in Echinococcus multilocularis that contributes to larval growth and development. |
title_full_unstemmed |
EGF-mediated EGFR/ERK signaling pathway promotes germinative cell proliferation in Echinococcus multilocularis that contributes to larval growth and development. |
title_sort |
egf-mediated egfr/erk signaling pathway promotes germinative cell proliferation in echinococcus multilocularis that contributes to larval growth and development. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://doi.org/10.1371/journal.pntd.0005418 https://doaj.org/article/5a3e8954b4754c52bcec2e972b22c1da |
long_lat |
ENVELOPE(7.086,7.086,62.735,62.735) |
geographic |
Arctic Mek |
geographic_facet |
Arctic Mek |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 11, Iss 2, p e0005418 (2017) |
op_relation |
http://europepmc.org/articles/PMC5344531?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005418 https://doaj.org/article/5a3e8954b4754c52bcec2e972b22c1da |
op_doi |
https://doi.org/10.1371/journal.pntd.0005418 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
11 |
container_issue |
2 |
container_start_page |
e0005418 |
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1766337192524775424 |