Clinical and hematological profiles of children with dengue residing in a non-endemic zone of Bangladesh.
Background The clinical and hematological parameters of children with dengue during an outbreak in a non-endemic region have not been well described. To delineate the clinical profile of pediatric cases from a tertiary care center located in a non-endemic zone (Tangail district) in Bangladesh was th...
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ftdoajarticles:oai:doaj.org/article:5a2623c240094a6daae4fb213c41c737 2023-05-15T15:15:24+02:00 Clinical and hematological profiles of children with dengue residing in a non-endemic zone of Bangladesh. Saiful Islam Md Abdullah Saeed Khan Md Fakhrul Amin Badal Muhammad Ziaul Islam Khan David Gozal Mohammad Jahid Hasan 2022-10-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0010847 https://doaj.org/article/5a2623c240094a6daae4fb213c41c737 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0010847 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010847 https://doaj.org/article/5a2623c240094a6daae4fb213c41c737 PLoS Neglected Tropical Diseases, Vol 16, Iss 10, p e0010847 (2022) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2022 ftdoajarticles https://doi.org/10.1371/journal.pntd.0010847 2022-12-30T22:56:19Z Background The clinical and hematological parameters of children with dengue during an outbreak in a non-endemic region have not been well described. To delineate the clinical profile of pediatric cases from a tertiary care center located in a non-endemic zone (Tangail district) in Bangladesh was the objective of the study. Methods A cross-sectional observational study was conducted in the Department of Pediatrics of a 250-bed general hospital in Tangail, Bangladesh, between June 2019 to September 2019. Data collection was done using a pre-structured case record form. All patients underwent detailed history taking, physical examination, and hematological profiling. A total of 123 confirmed dengue cases were analyzed. Results The average age of patients was 7.3±4.1 (SD) years, with nearly two-thirds being male (61.8%) and the majority living in rural areas (76.4%). Fever (100%), body ache (57.7%), headache (56.9%), and rash (55.3%) were the four common clinical manifestations. NS1 antigen and anti-dengue IgM antibody tests were positive in 86% (102 out of 119) and 37.7% (20 out of 53) of cases, respectively. Thrombocytopenia was present in 42% of cases. The majority of the cases had dengue fever (73.2%), and the remaining cases were either dengue hemorrhagic fever or dengue shock syndrome (26.8%). Clinical and hematological parameters varied with the type of dengue. Particularly, rash (p = <0.001), bleeding manifestation (p = <0.001), vomiting (p = 0.012), hypotension (p = 0.018), pleural effusion (p = 0.018), ascites (p = 0.018), hepatomegaly (p = <0.001) and low platelet count (<150 x 103cells/μL) (p = 0.038) were significantly more common among dengue hemorrhagic fever or dengue shock syndrome cases. Conclusions The present study documented the clinical features of dengue in a pediatric group of patients from a non-endemic zone of Bangladesh. This vulnerable patient group requires earlier identification and keen attention during management. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 16 10 e0010847 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Saiful Islam Md Abdullah Saeed Khan Md Fakhrul Amin Badal Muhammad Ziaul Islam Khan David Gozal Mohammad Jahid Hasan Clinical and hematological profiles of children with dengue residing in a non-endemic zone of Bangladesh. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background The clinical and hematological parameters of children with dengue during an outbreak in a non-endemic region have not been well described. To delineate the clinical profile of pediatric cases from a tertiary care center located in a non-endemic zone (Tangail district) in Bangladesh was the objective of the study. Methods A cross-sectional observational study was conducted in the Department of Pediatrics of a 250-bed general hospital in Tangail, Bangladesh, between June 2019 to September 2019. Data collection was done using a pre-structured case record form. All patients underwent detailed history taking, physical examination, and hematological profiling. A total of 123 confirmed dengue cases were analyzed. Results The average age of patients was 7.3±4.1 (SD) years, with nearly two-thirds being male (61.8%) and the majority living in rural areas (76.4%). Fever (100%), body ache (57.7%), headache (56.9%), and rash (55.3%) were the four common clinical manifestations. NS1 antigen and anti-dengue IgM antibody tests were positive in 86% (102 out of 119) and 37.7% (20 out of 53) of cases, respectively. Thrombocytopenia was present in 42% of cases. The majority of the cases had dengue fever (73.2%), and the remaining cases were either dengue hemorrhagic fever or dengue shock syndrome (26.8%). Clinical and hematological parameters varied with the type of dengue. Particularly, rash (p = <0.001), bleeding manifestation (p = <0.001), vomiting (p = 0.012), hypotension (p = 0.018), pleural effusion (p = 0.018), ascites (p = 0.018), hepatomegaly (p = <0.001) and low platelet count (<150 x 103cells/μL) (p = 0.038) were significantly more common among dengue hemorrhagic fever or dengue shock syndrome cases. Conclusions The present study documented the clinical features of dengue in a pediatric group of patients from a non-endemic zone of Bangladesh. This vulnerable patient group requires earlier identification and keen attention during management. |
format |
Article in Journal/Newspaper |
author |
Saiful Islam Md Abdullah Saeed Khan Md Fakhrul Amin Badal Muhammad Ziaul Islam Khan David Gozal Mohammad Jahid Hasan |
author_facet |
Saiful Islam Md Abdullah Saeed Khan Md Fakhrul Amin Badal Muhammad Ziaul Islam Khan David Gozal Mohammad Jahid Hasan |
author_sort |
Saiful Islam |
title |
Clinical and hematological profiles of children with dengue residing in a non-endemic zone of Bangladesh. |
title_short |
Clinical and hematological profiles of children with dengue residing in a non-endemic zone of Bangladesh. |
title_full |
Clinical and hematological profiles of children with dengue residing in a non-endemic zone of Bangladesh. |
title_fullStr |
Clinical and hematological profiles of children with dengue residing in a non-endemic zone of Bangladesh. |
title_full_unstemmed |
Clinical and hematological profiles of children with dengue residing in a non-endemic zone of Bangladesh. |
title_sort |
clinical and hematological profiles of children with dengue residing in a non-endemic zone of bangladesh. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2022 |
url |
https://doi.org/10.1371/journal.pntd.0010847 https://doaj.org/article/5a2623c240094a6daae4fb213c41c737 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 16, Iss 10, p e0010847 (2022) |
op_relation |
https://doi.org/10.1371/journal.pntd.0010847 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010847 https://doaj.org/article/5a2623c240094a6daae4fb213c41c737 |
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https://doi.org/10.1371/journal.pntd.0010847 |
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PLOS Neglected Tropical Diseases |
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