Functional characterization of 5' untranslated region (UTR) secondary RNA structures in the replication of tick-borne encephalitis virus in mammalian cells.

• Published in: PLOS Neglected Tropical Diseases
• Main Authors: Laura Upstone, Robin Colley, Mark Harris, Niluka Goonawardane
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2023
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; The ''Y''
• Online Access: https://doi.org/10.1371/journal.pntd.0011098; https://doaj.org/article/5a1288844aed44c49cfbec6140863941

Tick-borne Encephalitis Virus (TBEV) is an emerging flavivirus that causes neurological disorders including viral encephalitis of varying severity. Whilst secondary RNA structures within the 5' untranslated regions (UTRs) of many flaviviruses determine both virus replication and pathogenic outc...