Plug for the parasitophorous duct: a solution of two conundra
Abstract Background We present two conundra in the biology of intraerythrocytic malaria parasite: how an apparent open parasitophorous duct provide direct access of only a select set of serum proteins to the parasitophorous vacuole, and how proteases mediate membrane lysis to allow merozoite egress....
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Online Access: | https://doi.org/10.1186/s12936-020-03445-9 https://doaj.org/article/59f5e5e131824b8fa9d3dd8661c2d103 |
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ftdoajarticles:oai:doaj.org/article:59f5e5e131824b8fa9d3dd8661c2d103 2023-05-15T15:07:29+02:00 Plug for the parasitophorous duct: a solution of two conundra Prapon Wilairat Saranya Auparakkitanon 2020-10-01T00:00:00Z https://doi.org/10.1186/s12936-020-03445-9 https://doaj.org/article/59f5e5e131824b8fa9d3dd8661c2d103 EN eng BMC http://link.springer.com/article/10.1186/s12936-020-03445-9 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-020-03445-9 1475-2875 https://doaj.org/article/59f5e5e131824b8fa9d3dd8661c2d103 Malaria Journal, Vol 19, Iss 1, Pp 1-3 (2020) Plasmodium falciparum Merozoite egress Merozoite invasion Parasitophorous duct Parasitophorous vacuolar membrane Plug Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2020 ftdoajarticles https://doi.org/10.1186/s12936-020-03445-9 2022-12-31T08:22:02Z Abstract Background We present two conundra in the biology of intraerythrocytic malaria parasite: how an apparent open parasitophorous duct provide direct access of only a select set of serum proteins to the parasitophorous vacuole, and how proteases mediate membrane lysis to allow merozoite egress. Solution We posit the existence of a parasitophorous vacuolar duct plug that is originally formed from a tight junction (or parts thereof) between merozoite apical surface and red blood cell plasma membrane, which by moving over the parasite surface towards the posterior end draws the parasite into the host cell interior, and by remaining at the passage orifice provides a location of transporter(s) for import of serum proteins into parasitophorous vacuole and an opening for merozoite egress upon its dissolution/dismantling through protease(s) action. Conclusion This notion obviates the need of a distinct intact parasitophorous vacuolar membrane, which in the proposed model is an extension of the red blood cell membrane but still forms an intracellular compartment for parasite growth and development. The model is testable using existing high-resolution electron and X-ray tomography tools. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 19 1 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Plasmodium falciparum Merozoite egress Merozoite invasion Parasitophorous duct Parasitophorous vacuolar membrane Plug Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Plasmodium falciparum Merozoite egress Merozoite invasion Parasitophorous duct Parasitophorous vacuolar membrane Plug Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Prapon Wilairat Saranya Auparakkitanon Plug for the parasitophorous duct: a solution of two conundra |
topic_facet |
Plasmodium falciparum Merozoite egress Merozoite invasion Parasitophorous duct Parasitophorous vacuolar membrane Plug Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background We present two conundra in the biology of intraerythrocytic malaria parasite: how an apparent open parasitophorous duct provide direct access of only a select set of serum proteins to the parasitophorous vacuole, and how proteases mediate membrane lysis to allow merozoite egress. Solution We posit the existence of a parasitophorous vacuolar duct plug that is originally formed from a tight junction (or parts thereof) between merozoite apical surface and red blood cell plasma membrane, which by moving over the parasite surface towards the posterior end draws the parasite into the host cell interior, and by remaining at the passage orifice provides a location of transporter(s) for import of serum proteins into parasitophorous vacuole and an opening for merozoite egress upon its dissolution/dismantling through protease(s) action. Conclusion This notion obviates the need of a distinct intact parasitophorous vacuolar membrane, which in the proposed model is an extension of the red blood cell membrane but still forms an intracellular compartment for parasite growth and development. The model is testable using existing high-resolution electron and X-ray tomography tools. |
format |
Article in Journal/Newspaper |
author |
Prapon Wilairat Saranya Auparakkitanon |
author_facet |
Prapon Wilairat Saranya Auparakkitanon |
author_sort |
Prapon Wilairat |
title |
Plug for the parasitophorous duct: a solution of two conundra |
title_short |
Plug for the parasitophorous duct: a solution of two conundra |
title_full |
Plug for the parasitophorous duct: a solution of two conundra |
title_fullStr |
Plug for the parasitophorous duct: a solution of two conundra |
title_full_unstemmed |
Plug for the parasitophorous duct: a solution of two conundra |
title_sort |
plug for the parasitophorous duct: a solution of two conundra |
publisher |
BMC |
publishDate |
2020 |
url |
https://doi.org/10.1186/s12936-020-03445-9 https://doaj.org/article/59f5e5e131824b8fa9d3dd8661c2d103 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 19, Iss 1, Pp 1-3 (2020) |
op_relation |
http://link.springer.com/article/10.1186/s12936-020-03445-9 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-020-03445-9 1475-2875 https://doaj.org/article/59f5e5e131824b8fa9d3dd8661c2d103 |
op_doi |
https://doi.org/10.1186/s12936-020-03445-9 |
container_title |
Malaria Journal |
container_volume |
19 |
container_issue |
1 |
_version_ |
1766338978370289664 |