Investigating the Contribution of Peri-domestic Transmission to Risk of Zoonotic Malaria Infection in Humans.
In recent years, the primate malaria Plasmodium knowlesi has emerged in human populations throughout South East Asia, with the largest hotspot being in Sabah, Malaysian Borneo. Control efforts are hindered by limited knowledge of where and when people get exposed to mosquito vectors. It is assumed t...
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ftdoajarticles:oai:doaj.org/article:59bf97d1267047dcabe51e4df3807664 2023-05-15T15:13:37+02:00 Investigating the Contribution of Peri-domestic Transmission to Risk of Zoonotic Malaria Infection in Humans. Benny O Manin Heather M Ferguson Indra Vythilingam Kim Fornace Timothy William Steve J Torr Chris Drakeley Tock H Chua 2016-10-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005064 https://doaj.org/article/59bf97d1267047dcabe51e4df3807664 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5065189?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005064 https://doaj.org/article/59bf97d1267047dcabe51e4df3807664 PLoS Neglected Tropical Diseases, Vol 10, Iss 10, p e0005064 (2016) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2016 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005064 2022-12-31T13:27:19Z In recent years, the primate malaria Plasmodium knowlesi has emerged in human populations throughout South East Asia, with the largest hotspot being in Sabah, Malaysian Borneo. Control efforts are hindered by limited knowledge of where and when people get exposed to mosquito vectors. It is assumed that exposure occurs primarily when people are working in forest areas, but the role of other potential exposure routes (including domestic or peri-domestic transmission) has not been thoroughly investigated.We integrated entomological surveillance within a comprehensive case-control study occurring within a large hotspot of transmission in Sabah, Malaysia. Mosquitoes were collected at 28 pairs households composed of one where an occupant had a confirmed P. knowlesi infection within the preceding 3 weeks ("case") and an associated "control" where no infection was reported. Human landing catches were conducted to measure the number and diversity of mosquitoes host seeking inside houses and in the surrounding peri-domestic (outdoors but around the household) areas. The predominant malaria vector species was Anopheles balabacensis, most of which were caught outdoors in the early evening (6pm - 9pm). It was significantly more abundant in the peri-domestic area than inside houses (5.5-fold), and also higher at case than control households (0.28±0.194 vs 0.17±0.127, p<0.001). Ten out of 641 An. balabacensis tested were positive for simian malaria parasites, but none for P. knowlesi.This study shows there is a possibility that humans can be exposed to P. knowlesi infection around their homes. The vector is highly exophagic and few were caught indoors indicating interventions using bednets inside households may have relatively little impact. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 10 10 e0005064 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Benny O Manin Heather M Ferguson Indra Vythilingam Kim Fornace Timothy William Steve J Torr Chris Drakeley Tock H Chua Investigating the Contribution of Peri-domestic Transmission to Risk of Zoonotic Malaria Infection in Humans. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
In recent years, the primate malaria Plasmodium knowlesi has emerged in human populations throughout South East Asia, with the largest hotspot being in Sabah, Malaysian Borneo. Control efforts are hindered by limited knowledge of where and when people get exposed to mosquito vectors. It is assumed that exposure occurs primarily when people are working in forest areas, but the role of other potential exposure routes (including domestic or peri-domestic transmission) has not been thoroughly investigated.We integrated entomological surveillance within a comprehensive case-control study occurring within a large hotspot of transmission in Sabah, Malaysia. Mosquitoes were collected at 28 pairs households composed of one where an occupant had a confirmed P. knowlesi infection within the preceding 3 weeks ("case") and an associated "control" where no infection was reported. Human landing catches were conducted to measure the number and diversity of mosquitoes host seeking inside houses and in the surrounding peri-domestic (outdoors but around the household) areas. The predominant malaria vector species was Anopheles balabacensis, most of which were caught outdoors in the early evening (6pm - 9pm). It was significantly more abundant in the peri-domestic area than inside houses (5.5-fold), and also higher at case than control households (0.28±0.194 vs 0.17±0.127, p<0.001). Ten out of 641 An. balabacensis tested were positive for simian malaria parasites, but none for P. knowlesi.This study shows there is a possibility that humans can be exposed to P. knowlesi infection around their homes. The vector is highly exophagic and few were caught indoors indicating interventions using bednets inside households may have relatively little impact. |
format |
Article in Journal/Newspaper |
author |
Benny O Manin Heather M Ferguson Indra Vythilingam Kim Fornace Timothy William Steve J Torr Chris Drakeley Tock H Chua |
author_facet |
Benny O Manin Heather M Ferguson Indra Vythilingam Kim Fornace Timothy William Steve J Torr Chris Drakeley Tock H Chua |
author_sort |
Benny O Manin |
title |
Investigating the Contribution of Peri-domestic Transmission to Risk of Zoonotic Malaria Infection in Humans. |
title_short |
Investigating the Contribution of Peri-domestic Transmission to Risk of Zoonotic Malaria Infection in Humans. |
title_full |
Investigating the Contribution of Peri-domestic Transmission to Risk of Zoonotic Malaria Infection in Humans. |
title_fullStr |
Investigating the Contribution of Peri-domestic Transmission to Risk of Zoonotic Malaria Infection in Humans. |
title_full_unstemmed |
Investigating the Contribution of Peri-domestic Transmission to Risk of Zoonotic Malaria Infection in Humans. |
title_sort |
investigating the contribution of peri-domestic transmission to risk of zoonotic malaria infection in humans. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pntd.0005064 https://doaj.org/article/59bf97d1267047dcabe51e4df3807664 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 10, Iss 10, p e0005064 (2016) |
op_relation |
http://europepmc.org/articles/PMC5065189?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005064 https://doaj.org/article/59bf97d1267047dcabe51e4df3807664 |
op_doi |
https://doi.org/10.1371/journal.pntd.0005064 |
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PLOS Neglected Tropical Diseases |
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10 |
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10 |
container_start_page |
e0005064 |
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1766344155517157376 |