Phytochemical profiling and biological activity of Plectranthus amboinicus (Lour.) mediated by various solvent extracts against Aedes aegypti larvae and toxicity evaluation
Objective: To analyze the phytochemical compounds and to investigate the bio-toxic efficacy of various solvent extracts of Plectranthus amboinicus against mosquito larvae activity and lethality on non-targeting organisms. Methods: The methanol, ethyl acetate, hexane, and aqueous extracts of Plectran...
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ftdoajarticles:oai:doaj.org/article:594f911d83304365b3947ff0cd902ee4 2023-05-15T15:09:00+02:00 Phytochemical profiling and biological activity of Plectranthus amboinicus (Lour.) mediated by various solvent extracts against Aedes aegypti larvae and toxicity evaluation Deepak Paramasivam Balamuralikrishnan Balasubramanian Sungkwon Park Palanisamy Alagappan Tanushri Kaul Wenchao Liu Perumal Pachiappan 2020-01-01T00:00:00Z https://doi.org/10.4103/1995-7645.295360 https://doaj.org/article/594f911d83304365b3947ff0cd902ee4 EN eng Wolters Kluwer Medknow Publications http://www.apjtm.org/article.asp?issn=1995-7645;year=2020;volume=13;issue=11;spage=494;epage=502;aulast=Paramasivam https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.295360 https://doaj.org/article/594f911d83304365b3947ff0cd902ee4 Asian Pacific Journal of Tropical Medicine, Vol 13, Iss 11, Pp 494-502 (2020) plectranthus amboinicus cold percolation indian borage mosquitocidal Arctic medicine. Tropical medicine RC955-962 article 2020 ftdoajarticles https://doi.org/10.4103/1995-7645.295360 2023-01-08T01:31:18Z Objective: To analyze the phytochemical compounds and to investigate the bio-toxic efficacy of various solvent extracts of Plectranthus amboinicus against mosquito larvae activity and lethality on non-targeting organisms. Methods: The methanol, ethyl acetate, hexane, and aqueous extracts of Plectranthus amboinicus were subjected to analyze the mosquitocidal activity against the dengue vector, Aedes aegypti and toxicity assays on zebra fish and brine shrimp. Three replications were performed, and negative control was also maintained. Amongst, ethyl acetate extract of Plectranthus amboinicus was chosen for the determination of bio-active compounds. Results: The mosquitocidal assays of methanol and ethyl acetate extracts of Plectranthus amboinicus showed the maximal activity with minimal concentration against the 4th instar mosquito-larvae of Aedes aegypti through the following lethal concentration (LC50 and LC90) values: 53.36 & 92.51 μg/mL and 13.64 & 86.09 μg/mL, respectively. In addition, the plant extracts showed no toxicity on zebra fish embryo and brine shrimp assays. The gas-chromatography analysis of the ethyl acetate extract of Plectranthus amboinicus revealed the presence of seven different compounds. Among them, PAEA-fraction 60 contained a major active bioactive compound, hexadecanoic acid, methyl ester (270.0). Conclusions: Plectranthus amboinicus possesses mosquitocidal properties and could be used as a potential alternative source for preparing the mosquitocidal agents. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Indian Asian Pacific Journal of Tropical Medicine 13 11 494 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
plectranthus amboinicus cold percolation indian borage mosquitocidal Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
plectranthus amboinicus cold percolation indian borage mosquitocidal Arctic medicine. Tropical medicine RC955-962 Deepak Paramasivam Balamuralikrishnan Balasubramanian Sungkwon Park Palanisamy Alagappan Tanushri Kaul Wenchao Liu Perumal Pachiappan Phytochemical profiling and biological activity of Plectranthus amboinicus (Lour.) mediated by various solvent extracts against Aedes aegypti larvae and toxicity evaluation |
topic_facet |
plectranthus amboinicus cold percolation indian borage mosquitocidal Arctic medicine. Tropical medicine RC955-962 |
description |
Objective: To analyze the phytochemical compounds and to investigate the bio-toxic efficacy of various solvent extracts of Plectranthus amboinicus against mosquito larvae activity and lethality on non-targeting organisms. Methods: The methanol, ethyl acetate, hexane, and aqueous extracts of Plectranthus amboinicus were subjected to analyze the mosquitocidal activity against the dengue vector, Aedes aegypti and toxicity assays on zebra fish and brine shrimp. Three replications were performed, and negative control was also maintained. Amongst, ethyl acetate extract of Plectranthus amboinicus was chosen for the determination of bio-active compounds. Results: The mosquitocidal assays of methanol and ethyl acetate extracts of Plectranthus amboinicus showed the maximal activity with minimal concentration against the 4th instar mosquito-larvae of Aedes aegypti through the following lethal concentration (LC50 and LC90) values: 53.36 & 92.51 μg/mL and 13.64 & 86.09 μg/mL, respectively. In addition, the plant extracts showed no toxicity on zebra fish embryo and brine shrimp assays. The gas-chromatography analysis of the ethyl acetate extract of Plectranthus amboinicus revealed the presence of seven different compounds. Among them, PAEA-fraction 60 contained a major active bioactive compound, hexadecanoic acid, methyl ester (270.0). Conclusions: Plectranthus amboinicus possesses mosquitocidal properties and could be used as a potential alternative source for preparing the mosquitocidal agents. |
format |
Article in Journal/Newspaper |
author |
Deepak Paramasivam Balamuralikrishnan Balasubramanian Sungkwon Park Palanisamy Alagappan Tanushri Kaul Wenchao Liu Perumal Pachiappan |
author_facet |
Deepak Paramasivam Balamuralikrishnan Balasubramanian Sungkwon Park Palanisamy Alagappan Tanushri Kaul Wenchao Liu Perumal Pachiappan |
author_sort |
Deepak Paramasivam |
title |
Phytochemical profiling and biological activity of Plectranthus amboinicus (Lour.) mediated by various solvent extracts against Aedes aegypti larvae and toxicity evaluation |
title_short |
Phytochemical profiling and biological activity of Plectranthus amboinicus (Lour.) mediated by various solvent extracts against Aedes aegypti larvae and toxicity evaluation |
title_full |
Phytochemical profiling and biological activity of Plectranthus amboinicus (Lour.) mediated by various solvent extracts against Aedes aegypti larvae and toxicity evaluation |
title_fullStr |
Phytochemical profiling and biological activity of Plectranthus amboinicus (Lour.) mediated by various solvent extracts against Aedes aegypti larvae and toxicity evaluation |
title_full_unstemmed |
Phytochemical profiling and biological activity of Plectranthus amboinicus (Lour.) mediated by various solvent extracts against Aedes aegypti larvae and toxicity evaluation |
title_sort |
phytochemical profiling and biological activity of plectranthus amboinicus (lour.) mediated by various solvent extracts against aedes aegypti larvae and toxicity evaluation |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2020 |
url |
https://doi.org/10.4103/1995-7645.295360 https://doaj.org/article/594f911d83304365b3947ff0cd902ee4 |
geographic |
Arctic Indian |
geographic_facet |
Arctic Indian |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Medicine, Vol 13, Iss 11, Pp 494-502 (2020) |
op_relation |
http://www.apjtm.org/article.asp?issn=1995-7645;year=2020;volume=13;issue=11;spage=494;epage=502;aulast=Paramasivam https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.295360 https://doaj.org/article/594f911d83304365b3947ff0cd902ee4 |
op_doi |
https://doi.org/10.4103/1995-7645.295360 |
container_title |
Asian Pacific Journal of Tropical Medicine |
container_volume |
13 |
container_issue |
11 |
container_start_page |
494 |
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1766340263562706944 |