Ameliorative properties of Iranian Trigonella foenum-graecum L. seeds and Punica granatum L. peel extracts in streptozotocin-induced experimental diabetic guinea pigs
Objective: To assess the ameliorative properties of Iranian Trigonella foenum-graecum L. (T. foenum-graecum) seeds and Punica granatum L. (P. granatum) peel extracts against streptozotocin-induced diabetes in male guinea pigs. Methods: Sixty guinea pigs were divided into six groups (10 guinea pigs p...
Published in: | Asian Pacific Journal of Tropical Biomedicine |
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Wolters Kluwer Medknow Publications
2017
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Online Access: | https://doi.org/10.1016/j.apjtb.2016.12.004 https://doaj.org/article/5946aac7cbfa45ccbe1bddb0e2e7d394 |
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ftdoajarticles:oai:doaj.org/article:5946aac7cbfa45ccbe1bddb0e2e7d394 2023-05-15T15:11:20+02:00 Ameliorative properties of Iranian Trigonella foenum-graecum L. seeds and Punica granatum L. peel extracts in streptozotocin-induced experimental diabetic guinea pigs Nabil Abdel Salam Ahmed Hasona Mohammed Ahmed Qumani Turki Ahmed Alghassab Muath Abdulrahman Alghassab Abdullah Ali Alghabban 2017-03-01T00:00:00Z https://doi.org/10.1016/j.apjtb.2016.12.004 https://doaj.org/article/5946aac7cbfa45ccbe1bddb0e2e7d394 EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169116303744 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2016.12.004 https://doaj.org/article/5946aac7cbfa45ccbe1bddb0e2e7d394 Asian Pacific Journal of Tropical Biomedicine, Vol 7, Iss 3, Pp 234-239 (2017) Diabetes Iranian Trigonella foenum-graecum Seeds Punica granatum Peel Streptozotocin Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2017 ftdoajarticles https://doi.org/10.1016/j.apjtb.2016.12.004 2022-12-31T14:54:34Z Objective: To assess the ameliorative properties of Iranian Trigonella foenum-graecum L. (T. foenum-graecum) seeds and Punica granatum L. (P. granatum) peel extracts against streptozotocin-induced diabetes in male guinea pigs. Methods: Sixty guinea pigs were divided into six groups (10 guinea pigs per group). Group 1 consisted of normal animals. Groups 2 and 3 were treated with Iranian T. foenum-graecum seeds and P. granatum peel extract alone, respectively. Group 4 was treated with streptozotocin only; whereas Groups 5 and 6 receiving streptozotocin were treated with Iranian T. foenum-graecum seeds and P. granatum peel extract, respectively. All animals were treated for 30 days, and the body weight, blood and liver biochemical parameters were measured. Results: Guinea pigs exposed to streptozotocin showed an alteration in body weight gain, fasting glucose level, kidney function parameters (blood urea nitrogen and creatinine) as well as decreased serum and hepatic total protein level. In addition, it increased the cholesterol and triglyceride level, while decreasing the hepatic glucose-6 phosphate dehydrogenase activity, glycogen, glutathione content and hepatic catalase activity. Oral treatment with T. foenum-graecum seeds and P. granatum peel extracts revealed significant protective properties with respect to body weight gain and other biochemical parameters studied. Conclusions: The Iranian T. foenum-graecum seeds and P. granatum peel extracts are significantly potent in ameliorating diabetic condition induced by streptozotocin and improving various biochemical parameters in serum and liver of guinea pigs. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 7 3 234 239 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
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English |
topic |
Diabetes Iranian Trigonella foenum-graecum Seeds Punica granatum Peel Streptozotocin Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
Diabetes Iranian Trigonella foenum-graecum Seeds Punica granatum Peel Streptozotocin Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Nabil Abdel Salam Ahmed Hasona Mohammed Ahmed Qumani Turki Ahmed Alghassab Muath Abdulrahman Alghassab Abdullah Ali Alghabban Ameliorative properties of Iranian Trigonella foenum-graecum L. seeds and Punica granatum L. peel extracts in streptozotocin-induced experimental diabetic guinea pigs |
topic_facet |
Diabetes Iranian Trigonella foenum-graecum Seeds Punica granatum Peel Streptozotocin Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To assess the ameliorative properties of Iranian Trigonella foenum-graecum L. (T. foenum-graecum) seeds and Punica granatum L. (P. granatum) peel extracts against streptozotocin-induced diabetes in male guinea pigs. Methods: Sixty guinea pigs were divided into six groups (10 guinea pigs per group). Group 1 consisted of normal animals. Groups 2 and 3 were treated with Iranian T. foenum-graecum seeds and P. granatum peel extract alone, respectively. Group 4 was treated with streptozotocin only; whereas Groups 5 and 6 receiving streptozotocin were treated with Iranian T. foenum-graecum seeds and P. granatum peel extract, respectively. All animals were treated for 30 days, and the body weight, blood and liver biochemical parameters were measured. Results: Guinea pigs exposed to streptozotocin showed an alteration in body weight gain, fasting glucose level, kidney function parameters (blood urea nitrogen and creatinine) as well as decreased serum and hepatic total protein level. In addition, it increased the cholesterol and triglyceride level, while decreasing the hepatic glucose-6 phosphate dehydrogenase activity, glycogen, glutathione content and hepatic catalase activity. Oral treatment with T. foenum-graecum seeds and P. granatum peel extracts revealed significant protective properties with respect to body weight gain and other biochemical parameters studied. Conclusions: The Iranian T. foenum-graecum seeds and P. granatum peel extracts are significantly potent in ameliorating diabetic condition induced by streptozotocin and improving various biochemical parameters in serum and liver of guinea pigs. |
format |
Article in Journal/Newspaper |
author |
Nabil Abdel Salam Ahmed Hasona Mohammed Ahmed Qumani Turki Ahmed Alghassab Muath Abdulrahman Alghassab Abdullah Ali Alghabban |
author_facet |
Nabil Abdel Salam Ahmed Hasona Mohammed Ahmed Qumani Turki Ahmed Alghassab Muath Abdulrahman Alghassab Abdullah Ali Alghabban |
author_sort |
Nabil Abdel Salam Ahmed Hasona |
title |
Ameliorative properties of Iranian Trigonella foenum-graecum L. seeds and Punica granatum L. peel extracts in streptozotocin-induced experimental diabetic guinea pigs |
title_short |
Ameliorative properties of Iranian Trigonella foenum-graecum L. seeds and Punica granatum L. peel extracts in streptozotocin-induced experimental diabetic guinea pigs |
title_full |
Ameliorative properties of Iranian Trigonella foenum-graecum L. seeds and Punica granatum L. peel extracts in streptozotocin-induced experimental diabetic guinea pigs |
title_fullStr |
Ameliorative properties of Iranian Trigonella foenum-graecum L. seeds and Punica granatum L. peel extracts in streptozotocin-induced experimental diabetic guinea pigs |
title_full_unstemmed |
Ameliorative properties of Iranian Trigonella foenum-graecum L. seeds and Punica granatum L. peel extracts in streptozotocin-induced experimental diabetic guinea pigs |
title_sort |
ameliorative properties of iranian trigonella foenum-graecum l. seeds and punica granatum l. peel extracts in streptozotocin-induced experimental diabetic guinea pigs |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2017 |
url |
https://doi.org/10.1016/j.apjtb.2016.12.004 https://doaj.org/article/5946aac7cbfa45ccbe1bddb0e2e7d394 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 7, Iss 3, Pp 234-239 (2017) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169116303744 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2016.12.004 https://doaj.org/article/5946aac7cbfa45ccbe1bddb0e2e7d394 |
op_doi |
https://doi.org/10.1016/j.apjtb.2016.12.004 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
7 |
container_issue |
3 |
container_start_page |
234 |
op_container_end_page |
239 |
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1766342205017948160 |