Treatment outcomes and adverse drug reactions among patients with drug–resistant tuberculosis receiving all-oral, long–term regimens: First record viewing report from Pakistan
Objective: To assess the effectiveness and adverse drug reactions of all-oral regimens for patients with multidrug-resistant tuberculosis. Methods: This retrospective study was conducted at 10 Programmatic Management of Drug Resistant Tuberculosis sites in Punjab province of Pakistan. Patients recei...
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ftdoajarticles:oai:doaj.org/article:58f10e2029a748e4ac982156a8bc23ce 2023-11-12T04:13:28+01:00 Treatment outcomes and adverse drug reactions among patients with drug–resistant tuberculosis receiving all-oral, long–term regimens: First record viewing report from Pakistan Hira Aslam Asad Omar Razia Fatima Usman Rasool Aashifa Yaqoob Waseem Ullah Aamir Khan Yusra Habib Khan Tauqeer Hussain Mallhi 2023-01-01T00:00:00Z https://doi.org/10.4103/1995-7645.370148 https://doaj.org/article/58f10e2029a748e4ac982156a8bc23ce EN eng Wolters Kluwer Medknow Publications http://www.apjtm.org/article.asp?issn=1995-7645;year=2023;volume=16;issue=2;spage=58;epage=64;aulast=Aslam https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.370148 https://doaj.org/article/58f10e2029a748e4ac982156a8bc23ce Asian Pacific Journal of Tropical Medicine, Vol 16, Iss 2, Pp 58-64 (2023) all-oral long-term regimens long-term regimens bedaquiline linezolid clofazimine drug resistant tuberculosis treatment outcomes adsm Arctic medicine. Tropical medicine RC955-962 article 2023 ftdoajarticles https://doi.org/10.4103/1995-7645.370148 2023-10-29T00:38:43Z Objective: To assess the effectiveness and adverse drug reactions of all-oral regimens for patients with multidrug-resistant tuberculosis. Methods: This retrospective study was conducted at 10 Programmatic Management of Drug Resistant Tuberculosis sites in Punjab province of Pakistan. Patients receiving treatment for drug resistant tuberculosis from July 2019 to December 2020 with at least interim result i.e. 6th month culture conversion or final outcomes (cured, complete, lost to follow-up, failure, death) available, were included in the study. Data was extracted from electronic data management system. For the reporting and management of adverse drug events, active tuberculosis drug safety monitoring and management was implemented across all sites. All the data was analyzed using SPSS version 22. Results: Out of 947 drug resistant tuberculosis patients included in this study, 579 (68%) of the patients had final outcomes available. Of these, 384 (67.9%) successfully completed their treatment. Out of 368 (32%) patients who had their interim results available, all had their 6th month culture negative. Combining new medications was thought to result in serious adverse outcomes such as QT prolongation. However, this study did not record any severe adverse events among patients. Conclusions: All-oral regimens formulation guided by overall treatment effectiveness resulted in treatment outcomes comparable to those obtained with traditional injectable treatment. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Asian Pacific Journal of Tropical Medicine 16 2 58 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
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all-oral long-term regimens long-term regimens bedaquiline linezolid clofazimine drug resistant tuberculosis treatment outcomes adsm Arctic medicine. Tropical medicine RC955-962 |
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all-oral long-term regimens long-term regimens bedaquiline linezolid clofazimine drug resistant tuberculosis treatment outcomes adsm Arctic medicine. Tropical medicine RC955-962 Hira Aslam Asad Omar Razia Fatima Usman Rasool Aashifa Yaqoob Waseem Ullah Aamir Khan Yusra Habib Khan Tauqeer Hussain Mallhi Treatment outcomes and adverse drug reactions among patients with drug–resistant tuberculosis receiving all-oral, long–term regimens: First record viewing report from Pakistan |
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all-oral long-term regimens long-term regimens bedaquiline linezolid clofazimine drug resistant tuberculosis treatment outcomes adsm Arctic medicine. Tropical medicine RC955-962 |
description |
Objective: To assess the effectiveness and adverse drug reactions of all-oral regimens for patients with multidrug-resistant tuberculosis. Methods: This retrospective study was conducted at 10 Programmatic Management of Drug Resistant Tuberculosis sites in Punjab province of Pakistan. Patients receiving treatment for drug resistant tuberculosis from July 2019 to December 2020 with at least interim result i.e. 6th month culture conversion or final outcomes (cured, complete, lost to follow-up, failure, death) available, were included in the study. Data was extracted from electronic data management system. For the reporting and management of adverse drug events, active tuberculosis drug safety monitoring and management was implemented across all sites. All the data was analyzed using SPSS version 22. Results: Out of 947 drug resistant tuberculosis patients included in this study, 579 (68%) of the patients had final outcomes available. Of these, 384 (67.9%) successfully completed their treatment. Out of 368 (32%) patients who had their interim results available, all had their 6th month culture negative. Combining new medications was thought to result in serious adverse outcomes such as QT prolongation. However, this study did not record any severe adverse events among patients. Conclusions: All-oral regimens formulation guided by overall treatment effectiveness resulted in treatment outcomes comparable to those obtained with traditional injectable treatment. |
format |
Article in Journal/Newspaper |
author |
Hira Aslam Asad Omar Razia Fatima Usman Rasool Aashifa Yaqoob Waseem Ullah Aamir Khan Yusra Habib Khan Tauqeer Hussain Mallhi |
author_facet |
Hira Aslam Asad Omar Razia Fatima Usman Rasool Aashifa Yaqoob Waseem Ullah Aamir Khan Yusra Habib Khan Tauqeer Hussain Mallhi |
author_sort |
Hira Aslam |
title |
Treatment outcomes and adverse drug reactions among patients with drug–resistant tuberculosis receiving all-oral, long–term regimens: First record viewing report from Pakistan |
title_short |
Treatment outcomes and adverse drug reactions among patients with drug–resistant tuberculosis receiving all-oral, long–term regimens: First record viewing report from Pakistan |
title_full |
Treatment outcomes and adverse drug reactions among patients with drug–resistant tuberculosis receiving all-oral, long–term regimens: First record viewing report from Pakistan |
title_fullStr |
Treatment outcomes and adverse drug reactions among patients with drug–resistant tuberculosis receiving all-oral, long–term regimens: First record viewing report from Pakistan |
title_full_unstemmed |
Treatment outcomes and adverse drug reactions among patients with drug–resistant tuberculosis receiving all-oral, long–term regimens: First record viewing report from Pakistan |
title_sort |
treatment outcomes and adverse drug reactions among patients with drug–resistant tuberculosis receiving all-oral, long–term regimens: first record viewing report from pakistan |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2023 |
url |
https://doi.org/10.4103/1995-7645.370148 https://doaj.org/article/58f10e2029a748e4ac982156a8bc23ce |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Medicine, Vol 16, Iss 2, Pp 58-64 (2023) |
op_relation |
http://www.apjtm.org/article.asp?issn=1995-7645;year=2023;volume=16;issue=2;spage=58;epage=64;aulast=Aslam https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.370148 https://doaj.org/article/58f10e2029a748e4ac982156a8bc23ce |
op_doi |
https://doi.org/10.4103/1995-7645.370148 |
container_title |
Asian Pacific Journal of Tropical Medicine |
container_volume |
16 |
container_issue |
2 |
container_start_page |
58 |
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1782331460240277504 |