Pregnant sows immunized with Cryptosporidium parvum significantly reduced infection in newborn piglets challenged with C. parvum but not with C. hominis.
Background The piglet is the only model to investigate the immunogenic relationship between Cryptosporidium hominis and C. parvum, the species responsible for diarrhea in humans. Despite being indistinguishable antigenically, and high genetic homology between them, they are only moderately cross pro...
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ftdoajarticles:oai:doaj.org/article:58cd2af033e047a1945b2e4ba2d57956 2023-05-15T15:05:33+02:00 Pregnant sows immunized with Cryptosporidium parvum significantly reduced infection in newborn piglets challenged with C. parvum but not with C. hominis. Abhineet Sheoran Alison Carvalho Ruby Pina Mimbela Adam South Samuel Major Melanie Ginese Donald Girouard Saul Tzipori 2022-07-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0010690 https://doaj.org/article/58cd2af033e047a1945b2e4ba2d57956 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0010690 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010690 https://doaj.org/article/58cd2af033e047a1945b2e4ba2d57956 PLoS Neglected Tropical Diseases, Vol 16, Iss 7, p e0010690 (2022) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2022 ftdoajarticles https://doi.org/10.1371/journal.pntd.0010690 2022-12-30T20:39:38Z Background The piglet is the only model to investigate the immunogenic relationship between Cryptosporidium hominis and C. parvum, the species responsible for diarrhea in humans. Despite being indistinguishable antigenically, and high genetic homology between them, they are only moderately cross protective after an active infection. Methodology/principal findings Here we examined the degree of passive protection conferred to piglets suckling sows immunized during pregnancy with C. parvum. After birth suckling piglets were challenged orally with either C. parvum or C. hominis at age 5 days. Animals challenged with C. parvum had significant reduction of infection rate, while piglets challenged with C. hominis showed no reduction despite high C. parvum serum and colostrum IgG and IgA antibody. Conclusions/significance We add these data to earlier studies where we described that infection derived immunity provides partial cross-protection. Together, it appears that for full protection, vaccines against human cryptosporidiosis must contain antigenic elements derived from both species. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 16 7 e0010690 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Abhineet Sheoran Alison Carvalho Ruby Pina Mimbela Adam South Samuel Major Melanie Ginese Donald Girouard Saul Tzipori Pregnant sows immunized with Cryptosporidium parvum significantly reduced infection in newborn piglets challenged with C. parvum but not with C. hominis. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background The piglet is the only model to investigate the immunogenic relationship between Cryptosporidium hominis and C. parvum, the species responsible for diarrhea in humans. Despite being indistinguishable antigenically, and high genetic homology between them, they are only moderately cross protective after an active infection. Methodology/principal findings Here we examined the degree of passive protection conferred to piglets suckling sows immunized during pregnancy with C. parvum. After birth suckling piglets were challenged orally with either C. parvum or C. hominis at age 5 days. Animals challenged with C. parvum had significant reduction of infection rate, while piglets challenged with C. hominis showed no reduction despite high C. parvum serum and colostrum IgG and IgA antibody. Conclusions/significance We add these data to earlier studies where we described that infection derived immunity provides partial cross-protection. Together, it appears that for full protection, vaccines against human cryptosporidiosis must contain antigenic elements derived from both species. |
format |
Article in Journal/Newspaper |
author |
Abhineet Sheoran Alison Carvalho Ruby Pina Mimbela Adam South Samuel Major Melanie Ginese Donald Girouard Saul Tzipori |
author_facet |
Abhineet Sheoran Alison Carvalho Ruby Pina Mimbela Adam South Samuel Major Melanie Ginese Donald Girouard Saul Tzipori |
author_sort |
Abhineet Sheoran |
title |
Pregnant sows immunized with Cryptosporidium parvum significantly reduced infection in newborn piglets challenged with C. parvum but not with C. hominis. |
title_short |
Pregnant sows immunized with Cryptosporidium parvum significantly reduced infection in newborn piglets challenged with C. parvum but not with C. hominis. |
title_full |
Pregnant sows immunized with Cryptosporidium parvum significantly reduced infection in newborn piglets challenged with C. parvum but not with C. hominis. |
title_fullStr |
Pregnant sows immunized with Cryptosporidium parvum significantly reduced infection in newborn piglets challenged with C. parvum but not with C. hominis. |
title_full_unstemmed |
Pregnant sows immunized with Cryptosporidium parvum significantly reduced infection in newborn piglets challenged with C. parvum but not with C. hominis. |
title_sort |
pregnant sows immunized with cryptosporidium parvum significantly reduced infection in newborn piglets challenged with c. parvum but not with c. hominis. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2022 |
url |
https://doi.org/10.1371/journal.pntd.0010690 https://doaj.org/article/58cd2af033e047a1945b2e4ba2d57956 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 16, Iss 7, p e0010690 (2022) |
op_relation |
https://doi.org/10.1371/journal.pntd.0010690 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010690 https://doaj.org/article/58cd2af033e047a1945b2e4ba2d57956 |
op_doi |
https://doi.org/10.1371/journal.pntd.0010690 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
16 |
container_issue |
7 |
container_start_page |
e0010690 |
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1766337231577939968 |