Impairment of T cell function in parasitic infections.
In mammals subverted as hosts by protozoan parasites, the latter and/or the agonists they release are detected and processed by sensors displayed by many distinct immune cell lineages, in a tissue(s)-dependent context. Focusing on the T lymphocyte lineage, we review our present understanding on its...
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ftdoajarticles:oai:doaj.org/article:586fa2fc42414c91b52f8c21cf8c3bbe 2023-05-15T15:05:00+02:00 Impairment of T cell function in parasitic infections. Vasco Rodrigues Anabela Cordeiro-da-Silva Mireille Laforge Ali Ouaissi Khadija Akharid Ricardo Silvestre Jérôme Estaquier 2014-02-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0002567 https://doaj.org/article/586fa2fc42414c91b52f8c21cf8c3bbe EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3923671?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002567 https://doaj.org/article/586fa2fc42414c91b52f8c21cf8c3bbe PLoS Neglected Tropical Diseases, Vol 8, Iss 2, p e2567 (2014) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2014 ftdoajarticles https://doi.org/10.1371/journal.pntd.0002567 2022-12-31T14:11:43Z In mammals subverted as hosts by protozoan parasites, the latter and/or the agonists they release are detected and processed by sensors displayed by many distinct immune cell lineages, in a tissue(s)-dependent context. Focusing on the T lymphocyte lineage, we review our present understanding on its transient or durable functional impairment over the course of the developmental program of the intracellular parasites Leishmania spp., Plasmodium spp., Toxoplasma gondii, and Trypanosoma cruzi in their mammalian hosts. Strategies employed by protozoa to down-regulate T lymphocyte function may act at the initial moment of naïve T cell priming, rendering T cells anergic or unresponsive throughout infection, or later, exhausting T cells due to antigen persistence. Furthermore, by exploiting host feedback mechanisms aimed at maintaining immune homeostasis, parasites can enhance T cell apoptosis. We will discuss how infections with prominent intracellular protozoan parasites lead to a general down-regulation of T cell function through T cell anergy and exhaustion, accompanied by apoptosis, and ultimately allowing pathogen persistence. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 8 2 e2567 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Vasco Rodrigues Anabela Cordeiro-da-Silva Mireille Laforge Ali Ouaissi Khadija Akharid Ricardo Silvestre Jérôme Estaquier Impairment of T cell function in parasitic infections. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
In mammals subverted as hosts by protozoan parasites, the latter and/or the agonists they release are detected and processed by sensors displayed by many distinct immune cell lineages, in a tissue(s)-dependent context. Focusing on the T lymphocyte lineage, we review our present understanding on its transient or durable functional impairment over the course of the developmental program of the intracellular parasites Leishmania spp., Plasmodium spp., Toxoplasma gondii, and Trypanosoma cruzi in their mammalian hosts. Strategies employed by protozoa to down-regulate T lymphocyte function may act at the initial moment of naïve T cell priming, rendering T cells anergic or unresponsive throughout infection, or later, exhausting T cells due to antigen persistence. Furthermore, by exploiting host feedback mechanisms aimed at maintaining immune homeostasis, parasites can enhance T cell apoptosis. We will discuss how infections with prominent intracellular protozoan parasites lead to a general down-regulation of T cell function through T cell anergy and exhaustion, accompanied by apoptosis, and ultimately allowing pathogen persistence. |
format |
Article in Journal/Newspaper |
author |
Vasco Rodrigues Anabela Cordeiro-da-Silva Mireille Laforge Ali Ouaissi Khadija Akharid Ricardo Silvestre Jérôme Estaquier |
author_facet |
Vasco Rodrigues Anabela Cordeiro-da-Silva Mireille Laforge Ali Ouaissi Khadija Akharid Ricardo Silvestre Jérôme Estaquier |
author_sort |
Vasco Rodrigues |
title |
Impairment of T cell function in parasitic infections. |
title_short |
Impairment of T cell function in parasitic infections. |
title_full |
Impairment of T cell function in parasitic infections. |
title_fullStr |
Impairment of T cell function in parasitic infections. |
title_full_unstemmed |
Impairment of T cell function in parasitic infections. |
title_sort |
impairment of t cell function in parasitic infections. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2014 |
url |
https://doi.org/10.1371/journal.pntd.0002567 https://doaj.org/article/586fa2fc42414c91b52f8c21cf8c3bbe |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 8, Iss 2, p e2567 (2014) |
op_relation |
http://europepmc.org/articles/PMC3923671?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002567 https://doaj.org/article/586fa2fc42414c91b52f8c21cf8c3bbe |
op_doi |
https://doi.org/10.1371/journal.pntd.0002567 |
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PLoS Neglected Tropical Diseases |
container_volume |
8 |
container_issue |
2 |
container_start_page |
e2567 |
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1766336771231055872 |