Carbapenemasas KPC en Enterobacteriaceae aisladas en un Hospital de Maracaibo, Venezuela
Abstract: Carbapenems have generally been considered the pharmacotherapy of last resort for managing infections associated with health services caused by multidrug-resistant gram-negative bacteria. However, it is worrisome that this situation is being threatened worldwide with the appearance of bact...
Main Authors: | , , , , , |
---|---|
Format: | Article in Journal/Newspaper |
Language: | English Spanish |
Published: |
Universidad del Zulia,Facultad de Medicina,Departamento de Enfermedades Infecciosas y Tropicales
2014
|
Subjects: | |
Online Access: | https://doaj.org/article/586f741454cf4185b8cc6edab30a9910 |
id |
ftdoajarticles:oai:doaj.org/article:586f741454cf4185b8cc6edab30a9910 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:586f741454cf4185b8cc6edab30a9910 2023-10-01T03:54:18+02:00 Carbapenemasas KPC en Enterobacteriaceae aisladas en un Hospital de Maracaibo, Venezuela Gómez-Gamboa Liliana Perozo-Mena Armindo Lugo Judith Bermúdez-González José Zabala Irene Morales, Ever 2014-12-01T00:00:00Z https://doaj.org/article/586f741454cf4185b8cc6edab30a9910 EN ES eng spa Universidad del Zulia,Facultad de Medicina,Departamento de Enfermedades Infecciosas y Tropicales https://sites.google.com/prod/view/revistakasmera/vol%C3%BAmenes/2011-2015-vols-39-43/2014-v-42-n-2/89-104?authuser=0 https://doaj.org/toc/0075-5222 https://doaj.org/toc/2477-9628 0075-5222 2477-9628 https://doaj.org/article/586f741454cf4185b8cc6edab30a9910 Kasmera, Vol 42, Iss 2, Pp 89-104 (2014) Enterobacteriaceae carbapenemasas KPC susceptibilidad antibióticos KPC carbapenemase antibiotic susceptibility Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2014 ftdoajarticles 2023-09-03T00:41:29Z Abstract: Carbapenems have generally been considered the pharmacotherapy of last resort for managing infections associated with health services caused by multidrug-resistant gram-negative bacteria. However, it is worrisome that this situation is being threatened worldwide with the appearance of bacterial strains that resist these antibiotics due to the production of novel B-lactamases with direct carbapenem-hydrolyzing activity (carbapenemases). This study was performed to characterize KPC carbapenemase-producing Enterobacteriaceae isolated from a hospital in the Zulia region during 2009-2013. KPC carbapenemase production was detected in 423 strains of carbapenem-resistant Enterobacteriaceae (36.29%). The most affected patients were male adults from the intensive care unit. The most common site of colonization was the respiratory tract, while rectal carrier status was rare. These KPC carbapenemases were detected mainly in K. pneumoniae, K. oxytoca, E. coli and E. cloacae. Most isolates showed multidrug-resistance and an extensively drug-resistant phenotype. The majority of the phenotypic methods were effective for the detection of KPC producers in Enterobacteriaceae isolates and the presence of blaKPC gene confirmed that the Carbapenemase circulating in Enterobacteriaceae strains in this region are the KPC type. Resumen: Los antibióticos carbapenemes representan generalmente los últimos recursos para el tratamiento de infecciones asociadas a los servicios de salud producidas por bacterias Gram negativas multiresistentes. Es preocupante que esta situación esté siendo amenazada en todo el mundo por la aparición de cepas con resistencia a estos antibióticos debido a la producción de Carbapenemasas. Observando este panorama, se caracterizaron tanto fenotípica como genotípicamente las cepas de Enterobacteriaceae productoras de Carbapenemasas tipo KPC aisladas en un Hospital de la región Zuliana, durante 2009 a 2013. Fueron detectadas 423 cepas de Enterobacteriaceae resistentes a los carbapenemes debido a la ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English Spanish |
topic |
Enterobacteriaceae carbapenemasas KPC susceptibilidad antibióticos KPC carbapenemase antibiotic susceptibility Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Enterobacteriaceae carbapenemasas KPC susceptibilidad antibióticos KPC carbapenemase antibiotic susceptibility Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Gómez-Gamboa Liliana Perozo-Mena Armindo Lugo Judith Bermúdez-González José Zabala Irene Morales, Ever Carbapenemasas KPC en Enterobacteriaceae aisladas en un Hospital de Maracaibo, Venezuela |
topic_facet |
Enterobacteriaceae carbapenemasas KPC susceptibilidad antibióticos KPC carbapenemase antibiotic susceptibility Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Abstract: Carbapenems have generally been considered the pharmacotherapy of last resort for managing infections associated with health services caused by multidrug-resistant gram-negative bacteria. However, it is worrisome that this situation is being threatened worldwide with the appearance of bacterial strains that resist these antibiotics due to the production of novel B-lactamases with direct carbapenem-hydrolyzing activity (carbapenemases). This study was performed to characterize KPC carbapenemase-producing Enterobacteriaceae isolated from a hospital in the Zulia region during 2009-2013. KPC carbapenemase production was detected in 423 strains of carbapenem-resistant Enterobacteriaceae (36.29%). The most affected patients were male adults from the intensive care unit. The most common site of colonization was the respiratory tract, while rectal carrier status was rare. These KPC carbapenemases were detected mainly in K. pneumoniae, K. oxytoca, E. coli and E. cloacae. Most isolates showed multidrug-resistance and an extensively drug-resistant phenotype. The majority of the phenotypic methods were effective for the detection of KPC producers in Enterobacteriaceae isolates and the presence of blaKPC gene confirmed that the Carbapenemase circulating in Enterobacteriaceae strains in this region are the KPC type. Resumen: Los antibióticos carbapenemes representan generalmente los últimos recursos para el tratamiento de infecciones asociadas a los servicios de salud producidas por bacterias Gram negativas multiresistentes. Es preocupante que esta situación esté siendo amenazada en todo el mundo por la aparición de cepas con resistencia a estos antibióticos debido a la producción de Carbapenemasas. Observando este panorama, se caracterizaron tanto fenotípica como genotípicamente las cepas de Enterobacteriaceae productoras de Carbapenemasas tipo KPC aisladas en un Hospital de la región Zuliana, durante 2009 a 2013. Fueron detectadas 423 cepas de Enterobacteriaceae resistentes a los carbapenemes debido a la ... |
format |
Article in Journal/Newspaper |
author |
Gómez-Gamboa Liliana Perozo-Mena Armindo Lugo Judith Bermúdez-González José Zabala Irene Morales, Ever |
author_facet |
Gómez-Gamboa Liliana Perozo-Mena Armindo Lugo Judith Bermúdez-González José Zabala Irene Morales, Ever |
author_sort |
Gómez-Gamboa Liliana |
title |
Carbapenemasas KPC en Enterobacteriaceae aisladas en un Hospital de Maracaibo, Venezuela |
title_short |
Carbapenemasas KPC en Enterobacteriaceae aisladas en un Hospital de Maracaibo, Venezuela |
title_full |
Carbapenemasas KPC en Enterobacteriaceae aisladas en un Hospital de Maracaibo, Venezuela |
title_fullStr |
Carbapenemasas KPC en Enterobacteriaceae aisladas en un Hospital de Maracaibo, Venezuela |
title_full_unstemmed |
Carbapenemasas KPC en Enterobacteriaceae aisladas en un Hospital de Maracaibo, Venezuela |
title_sort |
carbapenemasas kpc en enterobacteriaceae aisladas en un hospital de maracaibo, venezuela |
publisher |
Universidad del Zulia,Facultad de Medicina,Departamento de Enfermedades Infecciosas y Tropicales |
publishDate |
2014 |
url |
https://doaj.org/article/586f741454cf4185b8cc6edab30a9910 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Kasmera, Vol 42, Iss 2, Pp 89-104 (2014) |
op_relation |
https://sites.google.com/prod/view/revistakasmera/vol%C3%BAmenes/2011-2015-vols-39-43/2014-v-42-n-2/89-104?authuser=0 https://doaj.org/toc/0075-5222 https://doaj.org/toc/2477-9628 0075-5222 2477-9628 https://doaj.org/article/586f741454cf4185b8cc6edab30a9910 |
_version_ |
1778521783910006784 |