Evaluation of residual submicroscopic Plasmodium falciparum parasites 3 days after initiation of treatment with artemisinin-based combination therapy
Abstract Plasmodium falciparum resistance against artemisinin has not emerged in Africa; however, there are reports of the presence of polymerase chain reaction-determined residual submicroscopic parasitaemia detected on day 3 after artemisinin-based combination therapy (ACT). These residual submicr...
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ftdoajarticles:oai:doaj.org/article:5841749055204817b7e5829efe82c47f 2023-05-15T15:07:28+02:00 Evaluation of residual submicroscopic Plasmodium falciparum parasites 3 days after initiation of treatment with artemisinin-based combination therapy Richard Mwaiswelo Bill Ngasala 2020-04-01T00:00:00Z https://doi.org/10.1186/s12936-020-03235-3 https://doaj.org/article/5841749055204817b7e5829efe82c47f EN eng BMC http://link.springer.com/article/10.1186/s12936-020-03235-3 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-020-03235-3 1475-2875 https://doaj.org/article/5841749055204817b7e5829efe82c47f Malaria Journal, Vol 19, Iss 1, Pp 1-9 (2020) Submicroscopic Parasites Day 3 Artemisinin-based combination therapy Transmission Resistance Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2020 ftdoajarticles https://doi.org/10.1186/s12936-020-03235-3 2022-12-30T22:59:54Z Abstract Plasmodium falciparum resistance against artemisinin has not emerged in Africa; however, there are reports of the presence of polymerase chain reaction-determined residual submicroscopic parasitaemia detected on day 3 after artemisinin-based combination therapy (ACT). These residual submicroscopic parasites are thought to represent tolerant/resistant parasites against artemisinin, the fast-acting component of the combination. This review focused on residual submicroscopic parasitaemia, what it represents, and its significance on the emergence and spread of artemisinin resistance in Africa. Presence of residual submicroscopic parasitemia on day 3 after treatment initiation leaves question on whether successful treatment is attained with ACT. Thus there is a need to determine the potential public health implication of the PCR-determined residual submicroscopic parasitaemia observed on day 3 after ACT. Robust techniques, such as in vitro cultivation, should be used to evaluate if the residual submicroscopic parasites detected on day 3 after ACT are viable asexual parasites, or gametocytes, or the DNA of the dead parasites waiting to be cleared from the circulation. Such techniques would also evaluate the transmissibility of these residual parasites. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 19 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Submicroscopic Parasites Day 3 Artemisinin-based combination therapy Transmission Resistance Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Submicroscopic Parasites Day 3 Artemisinin-based combination therapy Transmission Resistance Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Richard Mwaiswelo Bill Ngasala Evaluation of residual submicroscopic Plasmodium falciparum parasites 3 days after initiation of treatment with artemisinin-based combination therapy |
topic_facet |
Submicroscopic Parasites Day 3 Artemisinin-based combination therapy Transmission Resistance Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Plasmodium falciparum resistance against artemisinin has not emerged in Africa; however, there are reports of the presence of polymerase chain reaction-determined residual submicroscopic parasitaemia detected on day 3 after artemisinin-based combination therapy (ACT). These residual submicroscopic parasites are thought to represent tolerant/resistant parasites against artemisinin, the fast-acting component of the combination. This review focused on residual submicroscopic parasitaemia, what it represents, and its significance on the emergence and spread of artemisinin resistance in Africa. Presence of residual submicroscopic parasitemia on day 3 after treatment initiation leaves question on whether successful treatment is attained with ACT. Thus there is a need to determine the potential public health implication of the PCR-determined residual submicroscopic parasitaemia observed on day 3 after ACT. Robust techniques, such as in vitro cultivation, should be used to evaluate if the residual submicroscopic parasites detected on day 3 after ACT are viable asexual parasites, or gametocytes, or the DNA of the dead parasites waiting to be cleared from the circulation. Such techniques would also evaluate the transmissibility of these residual parasites. |
format |
Article in Journal/Newspaper |
author |
Richard Mwaiswelo Bill Ngasala |
author_facet |
Richard Mwaiswelo Bill Ngasala |
author_sort |
Richard Mwaiswelo |
title |
Evaluation of residual submicroscopic Plasmodium falciparum parasites 3 days after initiation of treatment with artemisinin-based combination therapy |
title_short |
Evaluation of residual submicroscopic Plasmodium falciparum parasites 3 days after initiation of treatment with artemisinin-based combination therapy |
title_full |
Evaluation of residual submicroscopic Plasmodium falciparum parasites 3 days after initiation of treatment with artemisinin-based combination therapy |
title_fullStr |
Evaluation of residual submicroscopic Plasmodium falciparum parasites 3 days after initiation of treatment with artemisinin-based combination therapy |
title_full_unstemmed |
Evaluation of residual submicroscopic Plasmodium falciparum parasites 3 days after initiation of treatment with artemisinin-based combination therapy |
title_sort |
evaluation of residual submicroscopic plasmodium falciparum parasites 3 days after initiation of treatment with artemisinin-based combination therapy |
publisher |
BMC |
publishDate |
2020 |
url |
https://doi.org/10.1186/s12936-020-03235-3 https://doaj.org/article/5841749055204817b7e5829efe82c47f |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 19, Iss 1, Pp 1-9 (2020) |
op_relation |
http://link.springer.com/article/10.1186/s12936-020-03235-3 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-020-03235-3 1475-2875 https://doaj.org/article/5841749055204817b7e5829efe82c47f |
op_doi |
https://doi.org/10.1186/s12936-020-03235-3 |
container_title |
Malaria Journal |
container_volume |
19 |
container_issue |
1 |
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1766338969259212800 |