Antivenom action on renal effects induced by Thalassophryne nattereri venom
Thalassophryne nattereri (niquim) is a venomous fish responsible for numerous accidents involving fishermen in northern and northeastern Brazil. The aim of the present investigation was to evaluate the action of antivenom on renal effects caused by Thalassophryne nattereri venom. Isolated kidneys of...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
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Online Access: | https://doi.org/10.1590/S1678-91992009000100011 https://doaj.org/article/58194b6a743a44e3865c43709b98fd3b |
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ftdoajarticles:oai:doaj.org/article:58194b6a743a44e3865c43709b98fd3b 2023-05-15T15:14:41+02:00 Antivenom action on renal effects induced by Thalassophryne nattereri venom AMC Martins PSF Barbosa DF Sousa CD Alves DB Menezes C Lima M Lopes-Ferreira MC Fonteles HSA Monteiro 2009-01-01T00:00:00Z https://doi.org/10.1590/S1678-91992009000100011 https://doaj.org/article/58194b6a743a44e3865c43709b98fd3b EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000100011 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992009000100011 1678-9199 https://doaj.org/article/58194b6a743a44e3865c43709b98fd3b Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 15, Iss 1, Pp 125-135 (2009) Thalassophryne nattereri antivenom kidney Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2009 ftdoajarticles https://doi.org/10.1590/S1678-91992009000100011 2022-12-30T23:27:53Z Thalassophryne nattereri (niquim) is a venomous fish responsible for numerous accidents involving fishermen in northern and northeastern Brazil. The aim of the present investigation was to evaluate the action of antivenom on renal effects caused by Thalassophryne nattereri venom. Isolated kidneys of Wistar rats were perfused with a previously dialyzed Krebs-Henseleit solution containing 6 g% bovine serum albumin. The antivenom action was studied through perfusion pressure (PP), renal vascular resistance (RVR), urinary flow (UF) and glomerular filtration rate (GFR). The niquim venom (1 µg/mL), the antivenom alone (1 µg/mL) or the venom incubated with antivenom were added to the system 30 minutes after the beginning of each perfusion. Previous works have shown venom induced-alterations of renal function parameters. In the isolated rat kidney, T. nattereri venom (1 µg/mL) increased the perfusion pressure and renal vascular resistance at 60, 90 and 120 minutes. UF and GFR also increased at 60, 90 and 120 minutes when compared with the control group; however, no effects were observed on the percent of sodium (%TNa+control = 81.1 ±0.86; %TNa+60 = 78.04 ±1.18; %TNa+90 = 76.16 ±3.34; %TNa+120 = 79.49 ±0.87) and potassium (%TK+control = 72.29 ±1.12; %TK+60 = 75.41 ±0.65; %TK+90 = 71.23 ±2.55; %TK+120 = 76.62 ±1.04) tubular transport. The administration of the antivenom (1 µg/mL) incubated with venom (1 µg/mL) reduced the changes in PP, RVR, UF and GFR provoked by Thalassophryne nattereri venom. The group perfused with venom alone showed a moderate deposit of a proteinaceous material in the tubules and urinary space. The group perfused with the antivenom presented similar results to the control group. In conclusion, the antivenom was able to decrease the effects induced by T. nattereri venom in isolated rat kidney. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Krebs ENVELOPE(-61.467,-61.467,-64.633,-64.633) Journal of Venomous Animals and Toxins including Tropical Diseases 15 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Thalassophryne nattereri antivenom kidney Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
Thalassophryne nattereri antivenom kidney Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 AMC Martins PSF Barbosa DF Sousa CD Alves DB Menezes C Lima M Lopes-Ferreira MC Fonteles HSA Monteiro Antivenom action on renal effects induced by Thalassophryne nattereri venom |
topic_facet |
Thalassophryne nattereri antivenom kidney Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Thalassophryne nattereri (niquim) is a venomous fish responsible for numerous accidents involving fishermen in northern and northeastern Brazil. The aim of the present investigation was to evaluate the action of antivenom on renal effects caused by Thalassophryne nattereri venom. Isolated kidneys of Wistar rats were perfused with a previously dialyzed Krebs-Henseleit solution containing 6 g% bovine serum albumin. The antivenom action was studied through perfusion pressure (PP), renal vascular resistance (RVR), urinary flow (UF) and glomerular filtration rate (GFR). The niquim venom (1 µg/mL), the antivenom alone (1 µg/mL) or the venom incubated with antivenom were added to the system 30 minutes after the beginning of each perfusion. Previous works have shown venom induced-alterations of renal function parameters. In the isolated rat kidney, T. nattereri venom (1 µg/mL) increased the perfusion pressure and renal vascular resistance at 60, 90 and 120 minutes. UF and GFR also increased at 60, 90 and 120 minutes when compared with the control group; however, no effects were observed on the percent of sodium (%TNa+control = 81.1 ±0.86; %TNa+60 = 78.04 ±1.18; %TNa+90 = 76.16 ±3.34; %TNa+120 = 79.49 ±0.87) and potassium (%TK+control = 72.29 ±1.12; %TK+60 = 75.41 ±0.65; %TK+90 = 71.23 ±2.55; %TK+120 = 76.62 ±1.04) tubular transport. The administration of the antivenom (1 µg/mL) incubated with venom (1 µg/mL) reduced the changes in PP, RVR, UF and GFR provoked by Thalassophryne nattereri venom. The group perfused with venom alone showed a moderate deposit of a proteinaceous material in the tubules and urinary space. The group perfused with the antivenom presented similar results to the control group. In conclusion, the antivenom was able to decrease the effects induced by T. nattereri venom in isolated rat kidney. |
format |
Article in Journal/Newspaper |
author |
AMC Martins PSF Barbosa DF Sousa CD Alves DB Menezes C Lima M Lopes-Ferreira MC Fonteles HSA Monteiro |
author_facet |
AMC Martins PSF Barbosa DF Sousa CD Alves DB Menezes C Lima M Lopes-Ferreira MC Fonteles HSA Monteiro |
author_sort |
AMC Martins |
title |
Antivenom action on renal effects induced by Thalassophryne nattereri venom |
title_short |
Antivenom action on renal effects induced by Thalassophryne nattereri venom |
title_full |
Antivenom action on renal effects induced by Thalassophryne nattereri venom |
title_fullStr |
Antivenom action on renal effects induced by Thalassophryne nattereri venom |
title_full_unstemmed |
Antivenom action on renal effects induced by Thalassophryne nattereri venom |
title_sort |
antivenom action on renal effects induced by thalassophryne nattereri venom |
publisher |
SciELO |
publishDate |
2009 |
url |
https://doi.org/10.1590/S1678-91992009000100011 https://doaj.org/article/58194b6a743a44e3865c43709b98fd3b |
long_lat |
ENVELOPE(-61.467,-61.467,-64.633,-64.633) |
geographic |
Arctic Krebs |
geographic_facet |
Arctic Krebs |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 15, Iss 1, Pp 125-135 (2009) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000100011 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992009000100011 1678-9199 https://doaj.org/article/58194b6a743a44e3865c43709b98fd3b |
op_doi |
https://doi.org/10.1590/S1678-91992009000100011 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
15 |
container_issue |
1 |
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1766345105576296448 |