Rhinacanthus nasutus leaf improves metabolic abnormalities in high-fat diet-induced obese mice
Objective: To investigate the effect of Rhinacanthus nasutus (R. nasutus) leaf extract on impaired glucose and lipid metabolism in obese ICR mice. Methods: Obesity was induced in the male ICR mice by feeding them a high-fat diet (60 kcal% fat) for 12 weeks. After the first six weeks of the diet, the...
Published in: | Asian Pacific Journal of Tropical Biomedicine |
---|---|
Main Authors: | , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2016
|
Subjects: | |
Online Access: | https://doi.org/10.1016/j.apjtb.2015.10.004 https://doaj.org/article/5818826f96f74f5f81987f53f7712378 |
id |
ftdoajarticles:oai:doaj.org/article:5818826f96f74f5f81987f53f7712378 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:5818826f96f74f5f81987f53f7712378 2023-05-15T15:13:24+02:00 Rhinacanthus nasutus leaf improves metabolic abnormalities in high-fat diet-induced obese mice Supaporn Wannasiri Pritsana Piyabhan Jarinyaporn Naowaboot 2016-01-01T00:00:00Z https://doi.org/10.1016/j.apjtb.2015.10.004 https://doaj.org/article/5818826f96f74f5f81987f53f7712378 EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169115002488 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2015.10.004 https://doaj.org/article/5818826f96f74f5f81987f53f7712378 Asian Pacific Journal of Tropical Biomedicine, Vol 6, Iss 1, Pp 1-7 (2016) Rhinacanthus nasutus Obesity Insulin sensitivity Adiponectin Peroxisome proliferators-activated receptor-α Glucose transporter 4 Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2016 ftdoajarticles https://doi.org/10.1016/j.apjtb.2015.10.004 2022-12-31T05:39:40Z Objective: To investigate the effect of Rhinacanthus nasutus (R. nasutus) leaf extract on impaired glucose and lipid metabolism in obese ICR mice. Methods: Obesity was induced in the male ICR mice by feeding them a high-fat diet (60 kcal% fat) for 12 weeks. After the first six weeks of the diet, the obese mice were administered with the water extract of R. nasutus leaves at 250 and 500 mg/kg per day for the next six weeks. Subsequently, the blood glucose, lipid profiles, insulin, leptin, and adiponectin levels were measured. The liver and adipose tissues were excised for histopathological examination and protein expression study. Results: After six weeks of the treatment, R. nasutus extract (at 250 and 500 mg/kg per day) was found to reduce the elevated blood glucose level, improve the insulin sensitivity, decrease the serum leptin, and increase the serum adiponectin levels. The obese mice treated with R. nasutus were found to have a reduction in the increased lipid concentrations in their serum and liver tissues. Moreover, treatment with R. nasutus reduced the fat accumulation in the liver and the large adipocyte size in the fat tissues. Interestingly, the administration with R. nasutus extract was marked by an increase in the hepatic peroxisome proliferators-activated receptor alpha, fat cell adiponectin, and glucose transporter 4 proteins. Conclusions: To the best of our knowledge, the present study is the first report on the impact of R. nasutus extract in improving the impaired glucose and lipid metabolism in high-fat diet-induced obesity in mice via stimulating the insulin sensitivity in the liver and adipose tissues. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 6 1 1 7 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Rhinacanthus nasutus Obesity Insulin sensitivity Adiponectin Peroxisome proliferators-activated receptor-α Glucose transporter 4 Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
Rhinacanthus nasutus Obesity Insulin sensitivity Adiponectin Peroxisome proliferators-activated receptor-α Glucose transporter 4 Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Supaporn Wannasiri Pritsana Piyabhan Jarinyaporn Naowaboot Rhinacanthus nasutus leaf improves metabolic abnormalities in high-fat diet-induced obese mice |
topic_facet |
Rhinacanthus nasutus Obesity Insulin sensitivity Adiponectin Peroxisome proliferators-activated receptor-α Glucose transporter 4 Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To investigate the effect of Rhinacanthus nasutus (R. nasutus) leaf extract on impaired glucose and lipid metabolism in obese ICR mice. Methods: Obesity was induced in the male ICR mice by feeding them a high-fat diet (60 kcal% fat) for 12 weeks. After the first six weeks of the diet, the obese mice were administered with the water extract of R. nasutus leaves at 250 and 500 mg/kg per day for the next six weeks. Subsequently, the blood glucose, lipid profiles, insulin, leptin, and adiponectin levels were measured. The liver and adipose tissues were excised for histopathological examination and protein expression study. Results: After six weeks of the treatment, R. nasutus extract (at 250 and 500 mg/kg per day) was found to reduce the elevated blood glucose level, improve the insulin sensitivity, decrease the serum leptin, and increase the serum adiponectin levels. The obese mice treated with R. nasutus were found to have a reduction in the increased lipid concentrations in their serum and liver tissues. Moreover, treatment with R. nasutus reduced the fat accumulation in the liver and the large adipocyte size in the fat tissues. Interestingly, the administration with R. nasutus extract was marked by an increase in the hepatic peroxisome proliferators-activated receptor alpha, fat cell adiponectin, and glucose transporter 4 proteins. Conclusions: To the best of our knowledge, the present study is the first report on the impact of R. nasutus extract in improving the impaired glucose and lipid metabolism in high-fat diet-induced obesity in mice via stimulating the insulin sensitivity in the liver and adipose tissues. |
format |
Article in Journal/Newspaper |
author |
Supaporn Wannasiri Pritsana Piyabhan Jarinyaporn Naowaboot |
author_facet |
Supaporn Wannasiri Pritsana Piyabhan Jarinyaporn Naowaboot |
author_sort |
Supaporn Wannasiri |
title |
Rhinacanthus nasutus leaf improves metabolic abnormalities in high-fat diet-induced obese mice |
title_short |
Rhinacanthus nasutus leaf improves metabolic abnormalities in high-fat diet-induced obese mice |
title_full |
Rhinacanthus nasutus leaf improves metabolic abnormalities in high-fat diet-induced obese mice |
title_fullStr |
Rhinacanthus nasutus leaf improves metabolic abnormalities in high-fat diet-induced obese mice |
title_full_unstemmed |
Rhinacanthus nasutus leaf improves metabolic abnormalities in high-fat diet-induced obese mice |
title_sort |
rhinacanthus nasutus leaf improves metabolic abnormalities in high-fat diet-induced obese mice |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2016 |
url |
https://doi.org/10.1016/j.apjtb.2015.10.004 https://doaj.org/article/5818826f96f74f5f81987f53f7712378 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 6, Iss 1, Pp 1-7 (2016) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169115002488 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2015.10.004 https://doaj.org/article/5818826f96f74f5f81987f53f7712378 |
op_doi |
https://doi.org/10.1016/j.apjtb.2015.10.004 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
6 |
container_issue |
1 |
container_start_page |
1 |
op_container_end_page |
7 |
_version_ |
1766343952817979392 |