The hamster cheek pouch: an immunologically privileged site suitable to the study of granulomatous infections A bolsa jugal do hamster: um local imunologicamente privilegiado, apropriado para o estudo das ¡nfecções granulomatosas
The hamster check pouch is an invagination of oral mucosa, characterized histologically as skin-like. In this paper we describe anatomical, histological and embriological features of the pouch and coment on the pouch as an immunologically privileged site since it lacks lymphatic drainage and has few...
Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
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Language: | English |
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Universidade de São Paulo (USP)
1995
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Online Access: | https://doi.org/10.1590/S0036-46651995000400004 https://doaj.org/article/57c306b4a52a426c81f05bf9233fbe1b |
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ftdoajarticles:oai:doaj.org/article:57c306b4a52a426c81f05bf9233fbe1b 2024-09-09T19:28:28+00:00 The hamster cheek pouch: an immunologically privileged site suitable to the study of granulomatous infections A bolsa jugal do hamster: um local imunologicamente privilegiado, apropriado para o estudo das ¡nfecções granulomatosas M. S. P. de Arruda M. R. Montenegro 1995-08-01T00:00:00Z https://doi.org/10.1590/S0036-46651995000400004 https://doaj.org/article/57c306b4a52a426c81f05bf9233fbe1b EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651995000400004 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46651995000400004 0036-4665 1678-9946 https://doaj.org/article/57c306b4a52a426c81f05bf9233fbe1b Revista do Instituto de Medicina Tropical de São Paulo, Vol 37, Iss 4, Pp 303-309 (1995) Hamster cheek pouch Inflammatory reactions Leprosy Paracoccidioidomycosis granuloma Mycobacterium leprae Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 1995 ftdoajarticles https://doi.org/10.1590/S0036-46651995000400004 2024-08-05T17:49:30Z The hamster check pouch is an invagination of oral mucosa, characterized histologically as skin-like. In this paper we describe anatomical, histological and embriological features of the pouch and coment on the pouch as an immunologically privileged site since it lacks lymphatic drainage and has few Langerhans cells. We present the review from literature and our observations after inoculation in the pouch of mycobacteriae (BCG, Mycobacterium tuberculosis and Mycobacterium leprae) and a fungus (Paracoccidioides brasiliensis). Lesions in the pouch were granulomatous but smaller and long lasting; even granulomatous, the reaction was inefficient to control the proliferation of agents compared with inoculation in other sites, except for BCG. Appearance of immunity was also delayed or absent and, when it was detected, a sharp decrease in number of agents in pouch lesions was observed. These observations make the pouch an interesting site for the study of the role of immune system in infeccious diseases and in granuloma formation. A bolsa jugal do hamster (BJH) é uma invaginação da mucosa oral, caracterizada histologicamente como semelhante a pele. Nesse estudo nós descrevemos algumas de suas características anatômicas, histológicas e embriológicas e comentamos sobre sua propriedade como local imunologicamente privilegiado, considerando a ausência de drenagem linfática e o reduzido número de células de Langerhans. Apresentamos também os resultados obtidos quando da inoculação de micobacterias (BCG, Mycobacterium tuberculosis e Mycobacterium leprae) e do fungo Paracoccidioides brasiliensis na bolsa jugal. Comparada com as lesões provocadas em outras localizações e, à exceção do BCG, as lesões induzidas na bolsa são menores e de maior duração e, mesmo quando granulomatosas, incapazes de controlar a multiplicação do agente; nos casos em que houve o desenvolvimento da resposta imune, ele se fez tardiamente e foi acompanhado pela redução do número de parasitas nas lesões. Essas observações apontam a bolsa jugal do hamster ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 37 4 303 309 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Hamster cheek pouch Inflammatory reactions Leprosy Paracoccidioidomycosis granuloma Mycobacterium leprae Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Hamster cheek pouch Inflammatory reactions Leprosy Paracoccidioidomycosis granuloma Mycobacterium leprae Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 M. S. P. de Arruda M. R. Montenegro The hamster cheek pouch: an immunologically privileged site suitable to the study of granulomatous infections A bolsa jugal do hamster: um local imunologicamente privilegiado, apropriado para o estudo das ¡nfecções granulomatosas |
topic_facet |
Hamster cheek pouch Inflammatory reactions Leprosy Paracoccidioidomycosis granuloma Mycobacterium leprae Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
The hamster check pouch is an invagination of oral mucosa, characterized histologically as skin-like. In this paper we describe anatomical, histological and embriological features of the pouch and coment on the pouch as an immunologically privileged site since it lacks lymphatic drainage and has few Langerhans cells. We present the review from literature and our observations after inoculation in the pouch of mycobacteriae (BCG, Mycobacterium tuberculosis and Mycobacterium leprae) and a fungus (Paracoccidioides brasiliensis). Lesions in the pouch were granulomatous but smaller and long lasting; even granulomatous, the reaction was inefficient to control the proliferation of agents compared with inoculation in other sites, except for BCG. Appearance of immunity was also delayed or absent and, when it was detected, a sharp decrease in number of agents in pouch lesions was observed. These observations make the pouch an interesting site for the study of the role of immune system in infeccious diseases and in granuloma formation. A bolsa jugal do hamster (BJH) é uma invaginação da mucosa oral, caracterizada histologicamente como semelhante a pele. Nesse estudo nós descrevemos algumas de suas características anatômicas, histológicas e embriológicas e comentamos sobre sua propriedade como local imunologicamente privilegiado, considerando a ausência de drenagem linfática e o reduzido número de células de Langerhans. Apresentamos também os resultados obtidos quando da inoculação de micobacterias (BCG, Mycobacterium tuberculosis e Mycobacterium leprae) e do fungo Paracoccidioides brasiliensis na bolsa jugal. Comparada com as lesões provocadas em outras localizações e, à exceção do BCG, as lesões induzidas na bolsa são menores e de maior duração e, mesmo quando granulomatosas, incapazes de controlar a multiplicação do agente; nos casos em que houve o desenvolvimento da resposta imune, ele se fez tardiamente e foi acompanhado pela redução do número de parasitas nas lesões. Essas observações apontam a bolsa jugal do hamster ... |
format |
Article in Journal/Newspaper |
author |
M. S. P. de Arruda M. R. Montenegro |
author_facet |
M. S. P. de Arruda M. R. Montenegro |
author_sort |
M. S. P. de Arruda |
title |
The hamster cheek pouch: an immunologically privileged site suitable to the study of granulomatous infections A bolsa jugal do hamster: um local imunologicamente privilegiado, apropriado para o estudo das ¡nfecções granulomatosas |
title_short |
The hamster cheek pouch: an immunologically privileged site suitable to the study of granulomatous infections A bolsa jugal do hamster: um local imunologicamente privilegiado, apropriado para o estudo das ¡nfecções granulomatosas |
title_full |
The hamster cheek pouch: an immunologically privileged site suitable to the study of granulomatous infections A bolsa jugal do hamster: um local imunologicamente privilegiado, apropriado para o estudo das ¡nfecções granulomatosas |
title_fullStr |
The hamster cheek pouch: an immunologically privileged site suitable to the study of granulomatous infections A bolsa jugal do hamster: um local imunologicamente privilegiado, apropriado para o estudo das ¡nfecções granulomatosas |
title_full_unstemmed |
The hamster cheek pouch: an immunologically privileged site suitable to the study of granulomatous infections A bolsa jugal do hamster: um local imunologicamente privilegiado, apropriado para o estudo das ¡nfecções granulomatosas |
title_sort |
hamster cheek pouch: an immunologically privileged site suitable to the study of granulomatous infections a bolsa jugal do hamster: um local imunologicamente privilegiado, apropriado para o estudo das ¡nfecções granulomatosas |
publisher |
Universidade de São Paulo (USP) |
publishDate |
1995 |
url |
https://doi.org/10.1590/S0036-46651995000400004 https://doaj.org/article/57c306b4a52a426c81f05bf9233fbe1b |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 37, Iss 4, Pp 303-309 (1995) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651995000400004 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46651995000400004 0036-4665 1678-9946 https://doaj.org/article/57c306b4a52a426c81f05bf9233fbe1b |
op_doi |
https://doi.org/10.1590/S0036-46651995000400004 |
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Revista do Instituto de Medicina Tropical de São Paulo |
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37 |
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