Cost minimization analysis of line probe assay for detection of multidrug-resistant tuberculosis in Arkhangelsk region of Russian Federation.
BACKGROUND:The development of new diagnostic tools allows for faster detection of both tuberculosis (TB) and multidrug-resistant (MDR) TB and should lead to reduced transmission by earlier initiation of anti TB therapy. The research conducted in the Arkhangelsk region of the Russian Federation in 20...
Published in: | PLOS ONE |
---|---|
Main Authors: | , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2019
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pone.0211203 https://doaj.org/article/5793eaf19f3e43aaba5eb933b16fbcbe |
id |
ftdoajarticles:oai:doaj.org/article:5793eaf19f3e43aaba5eb933b16fbcbe |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:5793eaf19f3e43aaba5eb933b16fbcbe 2023-05-15T15:23:47+02:00 Cost minimization analysis of line probe assay for detection of multidrug-resistant tuberculosis in Arkhangelsk region of Russian Federation. E N Bogdanova A O Mariandyshev G A Balantcev P I Eliseev E I Nikishova A I Gaida D Enarson A Detjen R Dacombe P P J Phillips S B Squire E Gospodarevskaya 2019-01-01T00:00:00Z https://doi.org/10.1371/journal.pone.0211203 https://doaj.org/article/5793eaf19f3e43aaba5eb933b16fbcbe EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pone.0211203 https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0211203 https://doaj.org/article/5793eaf19f3e43aaba5eb933b16fbcbe PLoS ONE, Vol 14, Iss 1, p e0211203 (2019) Medicine R Science Q article 2019 ftdoajarticles https://doi.org/10.1371/journal.pone.0211203 2022-12-31T13:17:42Z BACKGROUND:The development of new diagnostic tools allows for faster detection of both tuberculosis (TB) and multidrug-resistant (MDR) TB and should lead to reduced transmission by earlier initiation of anti TB therapy. The research conducted in the Arkhangelsk region of the Russian Federation in 2012-14 included economic evaluation of Line Probe Assay (LPA) implementation in MDR-TB diagnostics compared to existing culture-based diagnostics of Löwenstein Jensen (LJ) and BacTAlert. Clinical superiority of LPA was demonstrated and results were reported elsewhere. STUDY AIM:The PROVE-IT Russia study aimed to report the outcomes of the cost minimization analysis. METHODS:Costs of LPA-based diagnostic algorithm (smear positive (SSm+) and for smear negative (SSm-) culture confirmed TB patients by Bactec MGIT or LJ were compared with conventional culture-based algorithm (LJ-for SSm- and SSm+ patients and BacTAlert-for SSm+ patients). Cost minimization analysis was conducted from the healthcare system, patient and societal perspectives and included the direct and indirect costs to the healthcare system (microscopy and drug susceptibility test (DST), hospitalization, medications obtained from electronic medical records) and non-hospital direct costs (patient's travel cost, additional expenses associated with hospitalization, supplementary medicine and food) collected at the baseline and two subsequent interviews using the WHO-approved questionnaire. RESULTS:Over the period of treatment the LPA-based diagnostic corresponded to lesser direct and indirect costs comparing to the alternative algorithms. For SSm+ LPA-based diagnostics resulted in the costs 4.5 times less (808.21 US$) than LJ (3593.81 US$) and 2.5 times less than BacTAlert liquid culture (2009.61 US$). For SSm- LPA in combination with Bactec MGIT (1480.75 US$) vs LJ (1785.83 US$) showed the highest cost minimization compared to LJ (2566.09 US$). One-way sensitivity analyses of the key parameters and threshold analyses were conducted and demonstrated that the ... Article in Journal/Newspaper Arkhangelsk Directory of Open Access Journals: DOAJ Articles PLOS ONE 14 1 e0211203 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Medicine R Science Q |
spellingShingle |
Medicine R Science Q E N Bogdanova A O Mariandyshev G A Balantcev P I Eliseev E I Nikishova A I Gaida D Enarson A Detjen R Dacombe P P J Phillips S B Squire E Gospodarevskaya Cost minimization analysis of line probe assay for detection of multidrug-resistant tuberculosis in Arkhangelsk region of Russian Federation. |
topic_facet |
Medicine R Science Q |
description |
BACKGROUND:The development of new diagnostic tools allows for faster detection of both tuberculosis (TB) and multidrug-resistant (MDR) TB and should lead to reduced transmission by earlier initiation of anti TB therapy. The research conducted in the Arkhangelsk region of the Russian Federation in 2012-14 included economic evaluation of Line Probe Assay (LPA) implementation in MDR-TB diagnostics compared to existing culture-based diagnostics of Löwenstein Jensen (LJ) and BacTAlert. Clinical superiority of LPA was demonstrated and results were reported elsewhere. STUDY AIM:The PROVE-IT Russia study aimed to report the outcomes of the cost minimization analysis. METHODS:Costs of LPA-based diagnostic algorithm (smear positive (SSm+) and for smear negative (SSm-) culture confirmed TB patients by Bactec MGIT or LJ were compared with conventional culture-based algorithm (LJ-for SSm- and SSm+ patients and BacTAlert-for SSm+ patients). Cost minimization analysis was conducted from the healthcare system, patient and societal perspectives and included the direct and indirect costs to the healthcare system (microscopy and drug susceptibility test (DST), hospitalization, medications obtained from electronic medical records) and non-hospital direct costs (patient's travel cost, additional expenses associated with hospitalization, supplementary medicine and food) collected at the baseline and two subsequent interviews using the WHO-approved questionnaire. RESULTS:Over the period of treatment the LPA-based diagnostic corresponded to lesser direct and indirect costs comparing to the alternative algorithms. For SSm+ LPA-based diagnostics resulted in the costs 4.5 times less (808.21 US$) than LJ (3593.81 US$) and 2.5 times less than BacTAlert liquid culture (2009.61 US$). For SSm- LPA in combination with Bactec MGIT (1480.75 US$) vs LJ (1785.83 US$) showed the highest cost minimization compared to LJ (2566.09 US$). One-way sensitivity analyses of the key parameters and threshold analyses were conducted and demonstrated that the ... |
format |
Article in Journal/Newspaper |
author |
E N Bogdanova A O Mariandyshev G A Balantcev P I Eliseev E I Nikishova A I Gaida D Enarson A Detjen R Dacombe P P J Phillips S B Squire E Gospodarevskaya |
author_facet |
E N Bogdanova A O Mariandyshev G A Balantcev P I Eliseev E I Nikishova A I Gaida D Enarson A Detjen R Dacombe P P J Phillips S B Squire E Gospodarevskaya |
author_sort |
E N Bogdanova |
title |
Cost minimization analysis of line probe assay for detection of multidrug-resistant tuberculosis in Arkhangelsk region of Russian Federation. |
title_short |
Cost minimization analysis of line probe assay for detection of multidrug-resistant tuberculosis in Arkhangelsk region of Russian Federation. |
title_full |
Cost minimization analysis of line probe assay for detection of multidrug-resistant tuberculosis in Arkhangelsk region of Russian Federation. |
title_fullStr |
Cost minimization analysis of line probe assay for detection of multidrug-resistant tuberculosis in Arkhangelsk region of Russian Federation. |
title_full_unstemmed |
Cost minimization analysis of line probe assay for detection of multidrug-resistant tuberculosis in Arkhangelsk region of Russian Federation. |
title_sort |
cost minimization analysis of line probe assay for detection of multidrug-resistant tuberculosis in arkhangelsk region of russian federation. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2019 |
url |
https://doi.org/10.1371/journal.pone.0211203 https://doaj.org/article/5793eaf19f3e43aaba5eb933b16fbcbe |
genre |
Arkhangelsk |
genre_facet |
Arkhangelsk |
op_source |
PLoS ONE, Vol 14, Iss 1, p e0211203 (2019) |
op_relation |
https://doi.org/10.1371/journal.pone.0211203 https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0211203 https://doaj.org/article/5793eaf19f3e43aaba5eb933b16fbcbe |
op_doi |
https://doi.org/10.1371/journal.pone.0211203 |
container_title |
PLOS ONE |
container_volume |
14 |
container_issue |
1 |
container_start_page |
e0211203 |
_version_ |
1766354411770085376 |