The clinical relevance of MBL2 gene polymorphism and sepsis
Objective: To detect the clinical relevance of mannose-binding lectin 2 (MBL2) gene polymorphism and sepsis in Chinese lived in Hainan island. Methods: Blood samples from 57 patients with sepsis and 69 patients without sepsis were collected in the ICU of several large hospitals in Hainan province. G...
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Wolters Kluwer Medknow Publications
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ftdoajarticles:oai:doaj.org/article:576c63b6331342a2b8042ca8d3846301 2023-05-15T15:10:04+02:00 The clinical relevance of MBL2 gene polymorphism and sepsis Shao-Wen Cheng Li-Na Xian Zhi-Xing Lin Xue Ao Jun-Yi Yao Ying-Qing Li Yong-Yan Li Xiu-Ru Li Wei-Cheng Wang Chuan-Zhu Lyu Ying Li 2018-01-01T00:00:00Z https://doi.org/10.4103/1995-7645.228442 https://doaj.org/article/576c63b6331342a2b8042ca8d3846301 EN eng Wolters Kluwer Medknow Publications http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=3;spage=251;epage=254;aulast=Cheng https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.228442 https://doaj.org/article/576c63b6331342a2b8042ca8d3846301 Asian Pacific Journal of Tropical Medicine, Vol 11, Iss 3, Pp 251-254 (2018) mannose-binding lectin 2 polymorphism sepsis Arctic medicine. Tropical medicine RC955-962 article 2018 ftdoajarticles https://doi.org/10.4103/1995-7645.228442 2022-12-31T04:07:33Z Objective: To detect the clinical relevance of mannose-binding lectin 2 (MBL2) gene polymorphism and sepsis in Chinese lived in Hainan island. Methods: Blood samples from 57 patients with sepsis and 69 patients without sepsis were collected in the ICU of several large hospitals in Hainan province. Genomic DNA was extracted from whole blood and then PCR purification product was sequenced and typed by 3730 sequencing analyzer. The concentration of MBL2 in serum was detected by ELISA. Results: We found that genotype and allele distributions in two groups were in accordance with the Hardy-Weinberg Equilibrium. The frequency of GA genotype was significantly higher than that in non-sepsis group (P=0.013). A allele frequency in sepsis group was also much higher than that in non-sepsis group (P=0.028). Logister regression analysis showed that the patients who carried A allele were more prone to get sepsis than G allele carrier (P=0.014, 0R=2.550, 95%CI=1.207-5.386). The MBL2 level in serum of sepsis patients with genotype GG and GA was significantly lower than that in non-sepsis group (P<0.05). In sepsis group, the MBL2 serum level of patients with genotype GA was obviously lower than that in patients with genotype GG (P<0.05). Conclusions: The variation of rs1800450 G→A increased the incidence of sepsis and decreased the level of MBL2 in serum. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Medicine 11 3 251 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
mannose-binding lectin 2 polymorphism sepsis Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
mannose-binding lectin 2 polymorphism sepsis Arctic medicine. Tropical medicine RC955-962 Shao-Wen Cheng Li-Na Xian Zhi-Xing Lin Xue Ao Jun-Yi Yao Ying-Qing Li Yong-Yan Li Xiu-Ru Li Wei-Cheng Wang Chuan-Zhu Lyu Ying Li The clinical relevance of MBL2 gene polymorphism and sepsis |
topic_facet |
mannose-binding lectin 2 polymorphism sepsis Arctic medicine. Tropical medicine RC955-962 |
description |
Objective: To detect the clinical relevance of mannose-binding lectin 2 (MBL2) gene polymorphism and sepsis in Chinese lived in Hainan island. Methods: Blood samples from 57 patients with sepsis and 69 patients without sepsis were collected in the ICU of several large hospitals in Hainan province. Genomic DNA was extracted from whole blood and then PCR purification product was sequenced and typed by 3730 sequencing analyzer. The concentration of MBL2 in serum was detected by ELISA. Results: We found that genotype and allele distributions in two groups were in accordance with the Hardy-Weinberg Equilibrium. The frequency of GA genotype was significantly higher than that in non-sepsis group (P=0.013). A allele frequency in sepsis group was also much higher than that in non-sepsis group (P=0.028). Logister regression analysis showed that the patients who carried A allele were more prone to get sepsis than G allele carrier (P=0.014, 0R=2.550, 95%CI=1.207-5.386). The MBL2 level in serum of sepsis patients with genotype GG and GA was significantly lower than that in non-sepsis group (P<0.05). In sepsis group, the MBL2 serum level of patients with genotype GA was obviously lower than that in patients with genotype GG (P<0.05). Conclusions: The variation of rs1800450 G→A increased the incidence of sepsis and decreased the level of MBL2 in serum. |
format |
Article in Journal/Newspaper |
author |
Shao-Wen Cheng Li-Na Xian Zhi-Xing Lin Xue Ao Jun-Yi Yao Ying-Qing Li Yong-Yan Li Xiu-Ru Li Wei-Cheng Wang Chuan-Zhu Lyu Ying Li |
author_facet |
Shao-Wen Cheng Li-Na Xian Zhi-Xing Lin Xue Ao Jun-Yi Yao Ying-Qing Li Yong-Yan Li Xiu-Ru Li Wei-Cheng Wang Chuan-Zhu Lyu Ying Li |
author_sort |
Shao-Wen Cheng |
title |
The clinical relevance of MBL2 gene polymorphism and sepsis |
title_short |
The clinical relevance of MBL2 gene polymorphism and sepsis |
title_full |
The clinical relevance of MBL2 gene polymorphism and sepsis |
title_fullStr |
The clinical relevance of MBL2 gene polymorphism and sepsis |
title_full_unstemmed |
The clinical relevance of MBL2 gene polymorphism and sepsis |
title_sort |
clinical relevance of mbl2 gene polymorphism and sepsis |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2018 |
url |
https://doi.org/10.4103/1995-7645.228442 https://doaj.org/article/576c63b6331342a2b8042ca8d3846301 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Medicine, Vol 11, Iss 3, Pp 251-254 (2018) |
op_relation |
http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=3;spage=251;epage=254;aulast=Cheng https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.228442 https://doaj.org/article/576c63b6331342a2b8042ca8d3846301 |
op_doi |
https://doi.org/10.4103/1995-7645.228442 |
container_title |
Asian Pacific Journal of Tropical Medicine |
container_volume |
11 |
container_issue |
3 |
container_start_page |
251 |
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1766341131414536192 |