Alterations in lipid transfer to High-Density Lipoprotein (HDL) and activity of paraoxonase-1 in HIV+ patients Alterações na transferência de lípides para a lipoproteína de alta densidade (HDL) e atividade da paroxonase 1 em pacientes HIV+
HIV+ patients often develop alterations of the plasma lipids that may implicate in development of premature coronary artery disease. High-density lipoprotein (HDL) has an important role in preventing atherogenesis and the aim of this study was to investigate aspects of HDL function in HIV+ patients....
Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
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Universidade de São Paulo (USP)
2008
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ftdoajarticles:oai:doaj.org/article:57147e816fb9444ab7b5a5273a121af8 2024-09-09T19:28:27+00:00 Alterations in lipid transfer to High-Density Lipoprotein (HDL) and activity of paraoxonase-1 in HIV+ patients Alterações na transferência de lípides para a lipoproteína de alta densidade (HDL) e atividade da paroxonase 1 em pacientes HIV+ Elaine Nunes Daminelli Celso Spada Arício Treitinger Tatiane Vanessa Oliveira Maria da Conceição Latrilha Raul Cavalcante Maranhão 2008-08-01T00:00:00Z https://doi.org/10.1590/S0036-46652008000400007 https://doaj.org/article/57147e816fb9444ab7b5a5273a121af8 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652008000400007 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46652008000400007 0036-4665 1678-9946 https://doaj.org/article/57147e816fb9444ab7b5a5273a121af8 Revista do Instituto de Medicina Tropical de São Paulo, Vol 50, Iss 4, Pp 223-227 (2008) High-density lipoproteins Lipid Transfer Protein Paraoxonase-1 Lipids HIV AIDS Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2008 ftdoajarticles https://doi.org/10.1590/S0036-46652008000400007 2024-08-05T17:49:31Z HIV+ patients often develop alterations of the plasma lipids that may implicate in development of premature coronary artery disease. High-density lipoprotein (HDL) has an important role in preventing atherogenesis and the aim of this study was to investigate aspects of HDL function in HIV+ patients. HIV+ patients (n = 48) and healthy control subjects (n = 45) of both sexes with similar age were studied. Twenty-five were not being treated with antiretroviral agents, 13 were under reverse transcriptase inhibitor nucleosidic and non-nucleosidic (NRTI+NNRTI) and 10 were under NRTI + protease inhibitors (NRTI+PI) treatment. Paraoxonase 1 (PON1) activity and the transfer of free and esterified cholesterol, tryglicerides and phospholipids from a lipidic nanoemulsion to HDL were analyzed. In comparison with healthy controls, HIV+ patients presented low PON-1 activity and diminished transfer of free cholesterol and tryglicerides. In contrast, phospholipid transfer was increased in those patients, whereas the transfer of cholesteryl esters was unchanged. NRTI+NNRTI increases the transfer of cholesteryl esters and triglycerides but in NRTI+PI there was no difference in respect to non-treated HIV+ patients. HDL from HIV+ patients has smaller antioxidant properties, as shown by lower PON-1 activity, and the transfer of lipids to this lipoprotein fraction is also altered, suggesting that HDL function is defective in those patients. Pacientes HIV+ freqüentemente desenvolvem alterações no metabolismo de lípides que podem influir no desenvolvimento de doença arterial coronária. A lipoproteína de alta densidade (HDL) tem papel importante na prevenção da aterogênese. Para investigar aspectos funcionais da HDL na doença, foram estudados 48 pacientes HIV+ e 45 indivíduos-controle saudáveis de ambos os sexos, com idade semelhantes. Vinte e cinco pacientes HIV+ não recebiam terapia antirretroviral, 13 estavam sob tratamento com inibidores nucleosídicos de transcriptase reversa e não-nucleosídicos (NRTI+NNRTI) e 10 sob tratamento com ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Alta Sob’ ENVELOPE(66.156,66.156,66.322,66.322) Revista do Instituto de Medicina Tropical de São Paulo 50 4 223 227 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
High-density lipoproteins Lipid Transfer Protein Paraoxonase-1 Lipids HIV AIDS Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
High-density lipoproteins Lipid Transfer Protein Paraoxonase-1 Lipids HIV AIDS Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Elaine Nunes Daminelli Celso Spada Arício Treitinger Tatiane Vanessa Oliveira Maria da Conceição Latrilha Raul Cavalcante Maranhão Alterations in lipid transfer to High-Density Lipoprotein (HDL) and activity of paraoxonase-1 in HIV+ patients Alterações na transferência de lípides para a lipoproteína de alta densidade (HDL) e atividade da paroxonase 1 em pacientes HIV+ |
topic_facet |
High-density lipoproteins Lipid Transfer Protein Paraoxonase-1 Lipids HIV AIDS Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
HIV+ patients often develop alterations of the plasma lipids that may implicate in development of premature coronary artery disease. High-density lipoprotein (HDL) has an important role in preventing atherogenesis and the aim of this study was to investigate aspects of HDL function in HIV+ patients. HIV+ patients (n = 48) and healthy control subjects (n = 45) of both sexes with similar age were studied. Twenty-five were not being treated with antiretroviral agents, 13 were under reverse transcriptase inhibitor nucleosidic and non-nucleosidic (NRTI+NNRTI) and 10 were under NRTI + protease inhibitors (NRTI+PI) treatment. Paraoxonase 1 (PON1) activity and the transfer of free and esterified cholesterol, tryglicerides and phospholipids from a lipidic nanoemulsion to HDL were analyzed. In comparison with healthy controls, HIV+ patients presented low PON-1 activity and diminished transfer of free cholesterol and tryglicerides. In contrast, phospholipid transfer was increased in those patients, whereas the transfer of cholesteryl esters was unchanged. NRTI+NNRTI increases the transfer of cholesteryl esters and triglycerides but in NRTI+PI there was no difference in respect to non-treated HIV+ patients. HDL from HIV+ patients has smaller antioxidant properties, as shown by lower PON-1 activity, and the transfer of lipids to this lipoprotein fraction is also altered, suggesting that HDL function is defective in those patients. Pacientes HIV+ freqüentemente desenvolvem alterações no metabolismo de lípides que podem influir no desenvolvimento de doença arterial coronária. A lipoproteína de alta densidade (HDL) tem papel importante na prevenção da aterogênese. Para investigar aspectos funcionais da HDL na doença, foram estudados 48 pacientes HIV+ e 45 indivíduos-controle saudáveis de ambos os sexos, com idade semelhantes. Vinte e cinco pacientes HIV+ não recebiam terapia antirretroviral, 13 estavam sob tratamento com inibidores nucleosídicos de transcriptase reversa e não-nucleosídicos (NRTI+NNRTI) e 10 sob tratamento com ... |
format |
Article in Journal/Newspaper |
author |
Elaine Nunes Daminelli Celso Spada Arício Treitinger Tatiane Vanessa Oliveira Maria da Conceição Latrilha Raul Cavalcante Maranhão |
author_facet |
Elaine Nunes Daminelli Celso Spada Arício Treitinger Tatiane Vanessa Oliveira Maria da Conceição Latrilha Raul Cavalcante Maranhão |
author_sort |
Elaine Nunes Daminelli |
title |
Alterations in lipid transfer to High-Density Lipoprotein (HDL) and activity of paraoxonase-1 in HIV+ patients Alterações na transferência de lípides para a lipoproteína de alta densidade (HDL) e atividade da paroxonase 1 em pacientes HIV+ |
title_short |
Alterations in lipid transfer to High-Density Lipoprotein (HDL) and activity of paraoxonase-1 in HIV+ patients Alterações na transferência de lípides para a lipoproteína de alta densidade (HDL) e atividade da paroxonase 1 em pacientes HIV+ |
title_full |
Alterations in lipid transfer to High-Density Lipoprotein (HDL) and activity of paraoxonase-1 in HIV+ patients Alterações na transferência de lípides para a lipoproteína de alta densidade (HDL) e atividade da paroxonase 1 em pacientes HIV+ |
title_fullStr |
Alterations in lipid transfer to High-Density Lipoprotein (HDL) and activity of paraoxonase-1 in HIV+ patients Alterações na transferência de lípides para a lipoproteína de alta densidade (HDL) e atividade da paroxonase 1 em pacientes HIV+ |
title_full_unstemmed |
Alterations in lipid transfer to High-Density Lipoprotein (HDL) and activity of paraoxonase-1 in HIV+ patients Alterações na transferência de lípides para a lipoproteína de alta densidade (HDL) e atividade da paroxonase 1 em pacientes HIV+ |
title_sort |
alterations in lipid transfer to high-density lipoprotein (hdl) and activity of paraoxonase-1 in hiv+ patients alterações na transferência de lípides para a lipoproteína de alta densidade (hdl) e atividade da paroxonase 1 em pacientes hiv+ |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2008 |
url |
https://doi.org/10.1590/S0036-46652008000400007 https://doaj.org/article/57147e816fb9444ab7b5a5273a121af8 |
long_lat |
ENVELOPE(66.156,66.156,66.322,66.322) |
geographic |
Arctic Alta Sob’ |
geographic_facet |
Arctic Alta Sob’ |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 50, Iss 4, Pp 223-227 (2008) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652008000400007 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46652008000400007 0036-4665 1678-9946 https://doaj.org/article/57147e816fb9444ab7b5a5273a121af8 |
op_doi |
https://doi.org/10.1590/S0036-46652008000400007 |
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Revista do Instituto de Medicina Tropical de São Paulo |
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50 |
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223 |
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