Reduced exposure to malaria vectors following indoor residual spraying of pirimiphos-methyl in a high-burden district of rural Mozambique with high ownership of long-lasting insecticidal nets: entomological surveillance results from a cluster-randomized trial
Abstract Background The need to develop new products and novel approaches for malaria vector control is recognized as a global health priority. One approach to meeting this need has been the development of new products for indoor residual spraying (IRS) with novel active ingredients for public healt...
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ftdoajarticles:oai:doaj.org/article:5666b4d36d4e4e78a22e9ee9a70e8d88 2023-05-15T15:17:09+02:00 Reduced exposure to malaria vectors following indoor residual spraying of pirimiphos-methyl in a high-burden district of rural Mozambique with high ownership of long-lasting insecticidal nets: entomological surveillance results from a cluster-randomized trial Joseph M. Wagman Kenyssony Varela Rose Zulliger Abuchahama Saifodine Rodaly Muthoni Stephen Magesa Carlos Chaccour Christelle Gogue Kenzie Tynuv Aklilu Seyoum Dereje Dengela Francisco Saúte Jason H. Richardson Christen Fornadel Yvonne-Marie Linton Laurence Slutsker Baltazar Candrinho Molly Robertson 2021-01-01T00:00:00Z https://doi.org/10.1186/s12936-021-03583-8 https://doaj.org/article/5666b4d36d4e4e78a22e9ee9a70e8d88 EN eng BMC https://doi.org/10.1186/s12936-021-03583-8 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-021-03583-8 1475-2875 https://doaj.org/article/5666b4d36d4e4e78a22e9ee9a70e8d88 Malaria Journal, Vol 20, Iss 1, Pp 1-17 (2021) Indoor residual spraying 3GIRS Pyrethroid resistance An. funestus Cluster-randomized trial Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2021 ftdoajarticles https://doi.org/10.1186/s12936-021-03583-8 2022-12-31T10:33:08Z Abstract Background The need to develop new products and novel approaches for malaria vector control is recognized as a global health priority. One approach to meeting this need has been the development of new products for indoor residual spraying (IRS) with novel active ingredients for public health. While initial results showing the impact of several of these next-generation IRS products have been encouraging, questions remain about how to best deploy them for maximum impact. To help address these questions, a 2-year cluster-randomized controlled trial to measure the impact of IRS with a microencapsulated formulation of pirimiphos-methyl (PM) in an area with high ownership of long-lasting insecticidal nets (LLINs) was conducted in a high-transmission district of central Mozambique with pyrethroid resistant vectors. Presented here are the results of the vector surveillance component of the trial. Methods The 2 year, two-armed trial was conducted in Mopeia District, Zambezia Province, Mozambique. In ten sentinel villages, five that received IRS with PM in October–November 2016 and again in October–November 2017 and five that received no IRS, indoor light trap collections and paired indoor-outdoor human landing collections catches (HLCs) were conducted monthly from September 2016 through October 2018. A universal coverage campaign in June 2017, just prior to the second spray round, distributed 131,540 standard alpha-cypermethrin LLINs across all study villages and increased overall net usage rates in children under 5 years old to over 90%. Results The primary malaria vector during the trial was Anopheles funestus sensu lato (s.l.), and standard World Health Organization (WHO) tube tests with this population indicated variable but increasing resistance to pyrethroids (including alpha-cypermethrin, from > 85% mortality in 2017 to 7% mortality in 2018) and uniform susceptibility to PM (100% mortality in both years). Over the entire duration of the study, IRS reduced An. funestus s.l. densities by 48% (CI95 ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 20 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Indoor residual spraying 3GIRS Pyrethroid resistance An. funestus Cluster-randomized trial Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Indoor residual spraying 3GIRS Pyrethroid resistance An. funestus Cluster-randomized trial Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Joseph M. Wagman Kenyssony Varela Rose Zulliger Abuchahama Saifodine Rodaly Muthoni Stephen Magesa Carlos Chaccour Christelle Gogue Kenzie Tynuv Aklilu Seyoum Dereje Dengela Francisco Saúte Jason H. Richardson Christen Fornadel Yvonne-Marie Linton Laurence Slutsker Baltazar Candrinho Molly Robertson Reduced exposure to malaria vectors following indoor residual spraying of pirimiphos-methyl in a high-burden district of rural Mozambique with high ownership of long-lasting insecticidal nets: entomological surveillance results from a cluster-randomized trial |
topic_facet |
Indoor residual spraying 3GIRS Pyrethroid resistance An. funestus Cluster-randomized trial Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background The need to develop new products and novel approaches for malaria vector control is recognized as a global health priority. One approach to meeting this need has been the development of new products for indoor residual spraying (IRS) with novel active ingredients for public health. While initial results showing the impact of several of these next-generation IRS products have been encouraging, questions remain about how to best deploy them for maximum impact. To help address these questions, a 2-year cluster-randomized controlled trial to measure the impact of IRS with a microencapsulated formulation of pirimiphos-methyl (PM) in an area with high ownership of long-lasting insecticidal nets (LLINs) was conducted in a high-transmission district of central Mozambique with pyrethroid resistant vectors. Presented here are the results of the vector surveillance component of the trial. Methods The 2 year, two-armed trial was conducted in Mopeia District, Zambezia Province, Mozambique. In ten sentinel villages, five that received IRS with PM in October–November 2016 and again in October–November 2017 and five that received no IRS, indoor light trap collections and paired indoor-outdoor human landing collections catches (HLCs) were conducted monthly from September 2016 through October 2018. A universal coverage campaign in June 2017, just prior to the second spray round, distributed 131,540 standard alpha-cypermethrin LLINs across all study villages and increased overall net usage rates in children under 5 years old to over 90%. Results The primary malaria vector during the trial was Anopheles funestus sensu lato (s.l.), and standard World Health Organization (WHO) tube tests with this population indicated variable but increasing resistance to pyrethroids (including alpha-cypermethrin, from > 85% mortality in 2017 to 7% mortality in 2018) and uniform susceptibility to PM (100% mortality in both years). Over the entire duration of the study, IRS reduced An. funestus s.l. densities by 48% (CI95 ... |
format |
Article in Journal/Newspaper |
author |
Joseph M. Wagman Kenyssony Varela Rose Zulliger Abuchahama Saifodine Rodaly Muthoni Stephen Magesa Carlos Chaccour Christelle Gogue Kenzie Tynuv Aklilu Seyoum Dereje Dengela Francisco Saúte Jason H. Richardson Christen Fornadel Yvonne-Marie Linton Laurence Slutsker Baltazar Candrinho Molly Robertson |
author_facet |
Joseph M. Wagman Kenyssony Varela Rose Zulliger Abuchahama Saifodine Rodaly Muthoni Stephen Magesa Carlos Chaccour Christelle Gogue Kenzie Tynuv Aklilu Seyoum Dereje Dengela Francisco Saúte Jason H. Richardson Christen Fornadel Yvonne-Marie Linton Laurence Slutsker Baltazar Candrinho Molly Robertson |
author_sort |
Joseph M. Wagman |
title |
Reduced exposure to malaria vectors following indoor residual spraying of pirimiphos-methyl in a high-burden district of rural Mozambique with high ownership of long-lasting insecticidal nets: entomological surveillance results from a cluster-randomized trial |
title_short |
Reduced exposure to malaria vectors following indoor residual spraying of pirimiphos-methyl in a high-burden district of rural Mozambique with high ownership of long-lasting insecticidal nets: entomological surveillance results from a cluster-randomized trial |
title_full |
Reduced exposure to malaria vectors following indoor residual spraying of pirimiphos-methyl in a high-burden district of rural Mozambique with high ownership of long-lasting insecticidal nets: entomological surveillance results from a cluster-randomized trial |
title_fullStr |
Reduced exposure to malaria vectors following indoor residual spraying of pirimiphos-methyl in a high-burden district of rural Mozambique with high ownership of long-lasting insecticidal nets: entomological surveillance results from a cluster-randomized trial |
title_full_unstemmed |
Reduced exposure to malaria vectors following indoor residual spraying of pirimiphos-methyl in a high-burden district of rural Mozambique with high ownership of long-lasting insecticidal nets: entomological surveillance results from a cluster-randomized trial |
title_sort |
reduced exposure to malaria vectors following indoor residual spraying of pirimiphos-methyl in a high-burden district of rural mozambique with high ownership of long-lasting insecticidal nets: entomological surveillance results from a cluster-randomized trial |
publisher |
BMC |
publishDate |
2021 |
url |
https://doi.org/10.1186/s12936-021-03583-8 https://doaj.org/article/5666b4d36d4e4e78a22e9ee9a70e8d88 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 20, Iss 1, Pp 1-17 (2021) |
op_relation |
https://doi.org/10.1186/s12936-021-03583-8 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-021-03583-8 1475-2875 https://doaj.org/article/5666b4d36d4e4e78a22e9ee9a70e8d88 |
op_doi |
https://doi.org/10.1186/s12936-021-03583-8 |
container_title |
Malaria Journal |
container_volume |
20 |
container_issue |
1 |
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1766347418879655936 |