Bacterial and viral etiology of acute respiratory infection among the Forcibly Displaced Myanmar Nationals (FDMNs) in fragile settings in Cox’s Bazar- a prospective case-control study
The leading infectious cause of death in children worldwide is lower acute respiratory infection (LARI), particularly pneumonia. We enrolled a total of 538 acute respiratory infection (ARI) cases according to WHO criteria and age-sex matched 514 controls in the Forcibly Displaced Myanmar National (F...
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ftdoajarticles:oai:doaj.org/article:5638758dd9b744e688678f53a9154441 2023-06-06T11:51:39+02:00 Bacterial and viral etiology of acute respiratory infection among the Forcibly Displaced Myanmar Nationals (FDMNs) in fragile settings in Cox’s Bazar- a prospective case-control study Abu Bakar Siddik Nabid Anjum Tanvir Golam Sarower Bhuyan Md. Shahariar Alam Zahirul Islam Md. Rakibul Hassan Bulbul Md. Moniruzzaman Charls Erik Halder Tayabur Rahman Hubert Endtz Shakeel Ahmed Firdausi Qadri Valentina Sanchez Picot 2023-04-01T00:00:00Z https://doaj.org/article/5638758dd9b744e688678f53a9154441 EN eng Public Library of Science (PLoS) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085056/?tool=EBI https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 https://doaj.org/article/5638758dd9b744e688678f53a9154441 PLoS Neglected Tropical Diseases, Vol 17, Iss 4 (2023) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2023 ftdoajarticles 2023-04-16T00:32:23Z The leading infectious cause of death in children worldwide is lower acute respiratory infection (LARI), particularly pneumonia. We enrolled a total of 538 acute respiratory infection (ARI) cases according to WHO criteria and age-sex matched 514 controls in the Forcibly Displaced Myanmar National (FDMN) refugee camps in Cox’s Bazar, Bangladesh, between June 2018 and March 2020 to investigate the role of bacteria, viruses, and their co-infection patterns and observe Streptococcus pneumoniae (S. pneumoniae) serotype distribution. According to the etiological findings, children ≤5 years of age have a higher bacterial positivity (90%) and viral positivity (34%) in nasopharyngeal samples (NPS) compared to those >5 years of age, in both ARI cases as well as for the control group. Among the bacteria, S. pneumoniae was predominant in both cases and controls (85% and 88%). Adenovirus (ADV)(34), influenza virus A and B (IFV-A, B)(32,23), and respiratory syncytial virus (RSV)(26) were detected as the highest number among the viruses tested for the ARI cases. The total number of viruses was also found higher in ≤5 years of age group. Within this group, positive correlation was observed between bacteria and viruses but negative correlation was observed between bacteria. Both single and co-infection for viruses were found higher in the case group than the control group. However, co-infection was significantly high for Streptococcus aureus (S. aureus) and Haemophilus influenzae b (H. influenza b) (p<0.05). Additionally, semi-quantitative bacterial and viral load was found higher for the ARI cases over control considering Cycle threshold (Ct)≤30. Pathogen identification from blood specimens was higher by qRT-PCR than blood culture (16% vs 5%, p<0.05). In the S. pneumoniae serotype distribution, the predominant serotypes in ARI cases were 23F, 19A, 16F, 35B, 15A, 20 and 10F, while 11A, 10A, 34, 35A and 13 serotypes were predominant in the control group. Pathogen correlation analysis showed RSV positively correlated with ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Ari ENVELOPE(147.813,147.813,59.810,59.810) |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Abu Bakar Siddik Nabid Anjum Tanvir Golam Sarower Bhuyan Md. Shahariar Alam Zahirul Islam Md. Rakibul Hassan Bulbul Md. Moniruzzaman Charls Erik Halder Tayabur Rahman Hubert Endtz Shakeel Ahmed Firdausi Qadri Valentina Sanchez Picot Bacterial and viral etiology of acute respiratory infection among the Forcibly Displaced Myanmar Nationals (FDMNs) in fragile settings in Cox’s Bazar- a prospective case-control study |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
The leading infectious cause of death in children worldwide is lower acute respiratory infection (LARI), particularly pneumonia. We enrolled a total of 538 acute respiratory infection (ARI) cases according to WHO criteria and age-sex matched 514 controls in the Forcibly Displaced Myanmar National (FDMN) refugee camps in Cox’s Bazar, Bangladesh, between June 2018 and March 2020 to investigate the role of bacteria, viruses, and their co-infection patterns and observe Streptococcus pneumoniae (S. pneumoniae) serotype distribution. According to the etiological findings, children ≤5 years of age have a higher bacterial positivity (90%) and viral positivity (34%) in nasopharyngeal samples (NPS) compared to those >5 years of age, in both ARI cases as well as for the control group. Among the bacteria, S. pneumoniae was predominant in both cases and controls (85% and 88%). Adenovirus (ADV)(34), influenza virus A and B (IFV-A, B)(32,23), and respiratory syncytial virus (RSV)(26) were detected as the highest number among the viruses tested for the ARI cases. The total number of viruses was also found higher in ≤5 years of age group. Within this group, positive correlation was observed between bacteria and viruses but negative correlation was observed between bacteria. Both single and co-infection for viruses were found higher in the case group than the control group. However, co-infection was significantly high for Streptococcus aureus (S. aureus) and Haemophilus influenzae b (H. influenza b) (p<0.05). Additionally, semi-quantitative bacterial and viral load was found higher for the ARI cases over control considering Cycle threshold (Ct)≤30. Pathogen identification from blood specimens was higher by qRT-PCR than blood culture (16% vs 5%, p<0.05). In the S. pneumoniae serotype distribution, the predominant serotypes in ARI cases were 23F, 19A, 16F, 35B, 15A, 20 and 10F, while 11A, 10A, 34, 35A and 13 serotypes were predominant in the control group. Pathogen correlation analysis showed RSV positively correlated with ... |
format |
Article in Journal/Newspaper |
author |
Abu Bakar Siddik Nabid Anjum Tanvir Golam Sarower Bhuyan Md. Shahariar Alam Zahirul Islam Md. Rakibul Hassan Bulbul Md. Moniruzzaman Charls Erik Halder Tayabur Rahman Hubert Endtz Shakeel Ahmed Firdausi Qadri Valentina Sanchez Picot |
author_facet |
Abu Bakar Siddik Nabid Anjum Tanvir Golam Sarower Bhuyan Md. Shahariar Alam Zahirul Islam Md. Rakibul Hassan Bulbul Md. Moniruzzaman Charls Erik Halder Tayabur Rahman Hubert Endtz Shakeel Ahmed Firdausi Qadri Valentina Sanchez Picot |
author_sort |
Abu Bakar Siddik |
title |
Bacterial and viral etiology of acute respiratory infection among the Forcibly Displaced Myanmar Nationals (FDMNs) in fragile settings in Cox’s Bazar- a prospective case-control study |
title_short |
Bacterial and viral etiology of acute respiratory infection among the Forcibly Displaced Myanmar Nationals (FDMNs) in fragile settings in Cox’s Bazar- a prospective case-control study |
title_full |
Bacterial and viral etiology of acute respiratory infection among the Forcibly Displaced Myanmar Nationals (FDMNs) in fragile settings in Cox’s Bazar- a prospective case-control study |
title_fullStr |
Bacterial and viral etiology of acute respiratory infection among the Forcibly Displaced Myanmar Nationals (FDMNs) in fragile settings in Cox’s Bazar- a prospective case-control study |
title_full_unstemmed |
Bacterial and viral etiology of acute respiratory infection among the Forcibly Displaced Myanmar Nationals (FDMNs) in fragile settings in Cox’s Bazar- a prospective case-control study |
title_sort |
bacterial and viral etiology of acute respiratory infection among the forcibly displaced myanmar nationals (fdmns) in fragile settings in cox’s bazar- a prospective case-control study |
publisher |
Public Library of Science (PLoS) |
publishDate |
2023 |
url |
https://doaj.org/article/5638758dd9b744e688678f53a9154441 |
long_lat |
ENVELOPE(147.813,147.813,59.810,59.810) |
geographic |
Arctic Ari |
geographic_facet |
Arctic Ari |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 17, Iss 4 (2023) |
op_relation |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085056/?tool=EBI https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 https://doaj.org/article/5638758dd9b744e688678f53a9154441 |
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1767957338834075648 |