Plasmodium knowlesi infecting humans in Southeast Asia: What's next?
Plasmodium knowlesi, a simian malaria parasite, has been in the limelight since a large focus of human P. knowlesi infection was reported from Sarawak (Malaysian Borneo) in 2004. Although this infection is transmitted across Southeast Asia, the largest number of cases has been reported from Malaysia...
Published in: | PLOS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2020
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0008900 https://doaj.org/article/5629639a241e450a9267404f9bb2de31 |
id |
ftdoajarticles:oai:doaj.org/article:5629639a241e450a9267404f9bb2de31 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:5629639a241e450a9267404f9bb2de31 2023-05-15T15:05:10+02:00 Plasmodium knowlesi infecting humans in Southeast Asia: What's next? Nantha Kumar Jeyaprakasam Jonathan Wee Kent Liew Van Lun Low Wan-Yusoff Wan-Sulaiman Indra Vythilingam 2020-12-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0008900 https://doaj.org/article/5629639a241e450a9267404f9bb2de31 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0008900 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008900 https://doaj.org/article/5629639a241e450a9267404f9bb2de31 PLoS Neglected Tropical Diseases, Vol 14, Iss 12, p e0008900 (2020) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.1371/journal.pntd.0008900 2022-12-31T13:17:57Z Plasmodium knowlesi, a simian malaria parasite, has been in the limelight since a large focus of human P. knowlesi infection was reported from Sarawak (Malaysian Borneo) in 2004. Although this infection is transmitted across Southeast Asia, the largest number of cases has been reported from Malaysia. The increasing number of knowlesi malaria cases has been attributed to the use of molecular tools for detection, but environmental changes including deforestation likely play a major role by increasing human exposure to vector mosquitoes, which coexist with the macaque host. In addition, with the reduction in human malaria transmission in Southeast Asia, it is possible that human populations are at a greater risk of P. knowlesi infection due to diminishing cross-species immunity. Furthermore, the possibility of increasing exposure of humans to other simian Plasmodium parasites such as Plasmodium cynomolgi and Plasmodium inui should not be ignored. We here review the current status of these parasites in humans, macaques, and mosquitoes to support necessary reorientation of malaria control and elimination in the affected areas. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 14 12 e0008900 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Nantha Kumar Jeyaprakasam Jonathan Wee Kent Liew Van Lun Low Wan-Yusoff Wan-Sulaiman Indra Vythilingam Plasmodium knowlesi infecting humans in Southeast Asia: What's next? |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Plasmodium knowlesi, a simian malaria parasite, has been in the limelight since a large focus of human P. knowlesi infection was reported from Sarawak (Malaysian Borneo) in 2004. Although this infection is transmitted across Southeast Asia, the largest number of cases has been reported from Malaysia. The increasing number of knowlesi malaria cases has been attributed to the use of molecular tools for detection, but environmental changes including deforestation likely play a major role by increasing human exposure to vector mosquitoes, which coexist with the macaque host. In addition, with the reduction in human malaria transmission in Southeast Asia, it is possible that human populations are at a greater risk of P. knowlesi infection due to diminishing cross-species immunity. Furthermore, the possibility of increasing exposure of humans to other simian Plasmodium parasites such as Plasmodium cynomolgi and Plasmodium inui should not be ignored. We here review the current status of these parasites in humans, macaques, and mosquitoes to support necessary reorientation of malaria control and elimination in the affected areas. |
format |
Article in Journal/Newspaper |
author |
Nantha Kumar Jeyaprakasam Jonathan Wee Kent Liew Van Lun Low Wan-Yusoff Wan-Sulaiman Indra Vythilingam |
author_facet |
Nantha Kumar Jeyaprakasam Jonathan Wee Kent Liew Van Lun Low Wan-Yusoff Wan-Sulaiman Indra Vythilingam |
author_sort |
Nantha Kumar Jeyaprakasam |
title |
Plasmodium knowlesi infecting humans in Southeast Asia: What's next? |
title_short |
Plasmodium knowlesi infecting humans in Southeast Asia: What's next? |
title_full |
Plasmodium knowlesi infecting humans in Southeast Asia: What's next? |
title_fullStr |
Plasmodium knowlesi infecting humans in Southeast Asia: What's next? |
title_full_unstemmed |
Plasmodium knowlesi infecting humans in Southeast Asia: What's next? |
title_sort |
plasmodium knowlesi infecting humans in southeast asia: what's next? |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pntd.0008900 https://doaj.org/article/5629639a241e450a9267404f9bb2de31 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 14, Iss 12, p e0008900 (2020) |
op_relation |
https://doi.org/10.1371/journal.pntd.0008900 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008900 https://doaj.org/article/5629639a241e450a9267404f9bb2de31 |
op_doi |
https://doi.org/10.1371/journal.pntd.0008900 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
14 |
container_issue |
12 |
container_start_page |
e0008900 |
_version_ |
1766336925149429760 |