Re-examination of the risk of dementia after dengue virus infection: A population-based cohort study.
Dengue infection can affect the central nervous system and cause various neurological complications. Previous studies also suggest dengue was associated with a significantly increased long-term risk of dementia. A population-based cohort study was conducted using national health databases in Taiwan...
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ftdoajarticles:oai:doaj.org/article:55fd547fc3624bafb5470baeee1f6d9d 2024-01-28T10:04:00+01:00 Re-examination of the risk of dementia after dengue virus infection: A population-based cohort study. Yu-Wen Chien Hsin-I Shih Yu-Ping Wang Chia-Yu Chi 2023-12-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0011788 https://doaj.org/article/55fd547fc3624bafb5470baeee1f6d9d EN eng Public Library of Science (PLoS) https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0011788&type=printable https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0011788 https://doaj.org/article/55fd547fc3624bafb5470baeee1f6d9d PLoS Neglected Tropical Diseases, Vol 17, Iss 12, p e0011788 (2023) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2023 ftdoajarticles https://doi.org/10.1371/journal.pntd.0011788 2023-12-31T01:49:22Z Dengue infection can affect the central nervous system and cause various neurological complications. Previous studies also suggest dengue was associated with a significantly increased long-term risk of dementia. A population-based cohort study was conducted using national health databases in Taiwan and included 37,928 laboratory-confirmed dengue patients aged ≥ 45 years between 2002 and 2015, along with 151,712 matched nondengue individuals. Subdistribution hazard regression models showed a slightly increased risk of Alzheimer's disease, and unspecified dementia, non-vascular dementia, and overall dementia in dengue patients than the nondengue group, adjusted for age, sex, area of residence, urbanization level, income, comorbidities, and all-cause clinical visits within one year before the index date. After considering multiple comparisons using Bonferroni correction, only overall dementia and non-vascular dementia remained statistically significant (adjusted SHR 1.13, 95% CI 1.05-1.21, p = 0.0009; E-value 1.51, 95% CI 1.28-NA). Sensitivity analyses in which dementia cases occurring in the first three or five years after the index dates were excluded revealed no association between dengue and dementia. In conclusion, this study found dengue patients had a slightly increased risk of non-vascular dementia and total dementia than those without dengue. However, the small corresponding E-values and sensitivity analyses suggest the association between dengue and dementia may not be causal. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 17 12 e0011788 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Yu-Wen Chien Hsin-I Shih Yu-Ping Wang Chia-Yu Chi Re-examination of the risk of dementia after dengue virus infection: A population-based cohort study. |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Dengue infection can affect the central nervous system and cause various neurological complications. Previous studies also suggest dengue was associated with a significantly increased long-term risk of dementia. A population-based cohort study was conducted using national health databases in Taiwan and included 37,928 laboratory-confirmed dengue patients aged ≥ 45 years between 2002 and 2015, along with 151,712 matched nondengue individuals. Subdistribution hazard regression models showed a slightly increased risk of Alzheimer's disease, and unspecified dementia, non-vascular dementia, and overall dementia in dengue patients than the nondengue group, adjusted for age, sex, area of residence, urbanization level, income, comorbidities, and all-cause clinical visits within one year before the index date. After considering multiple comparisons using Bonferroni correction, only overall dementia and non-vascular dementia remained statistically significant (adjusted SHR 1.13, 95% CI 1.05-1.21, p = 0.0009; E-value 1.51, 95% CI 1.28-NA). Sensitivity analyses in which dementia cases occurring in the first three or five years after the index dates were excluded revealed no association between dengue and dementia. In conclusion, this study found dengue patients had a slightly increased risk of non-vascular dementia and total dementia than those without dengue. However, the small corresponding E-values and sensitivity analyses suggest the association between dengue and dementia may not be causal. |
format |
Article in Journal/Newspaper |
author |
Yu-Wen Chien Hsin-I Shih Yu-Ping Wang Chia-Yu Chi |
author_facet |
Yu-Wen Chien Hsin-I Shih Yu-Ping Wang Chia-Yu Chi |
author_sort |
Yu-Wen Chien |
title |
Re-examination of the risk of dementia after dengue virus infection: A population-based cohort study. |
title_short |
Re-examination of the risk of dementia after dengue virus infection: A population-based cohort study. |
title_full |
Re-examination of the risk of dementia after dengue virus infection: A population-based cohort study. |
title_fullStr |
Re-examination of the risk of dementia after dengue virus infection: A population-based cohort study. |
title_full_unstemmed |
Re-examination of the risk of dementia after dengue virus infection: A population-based cohort study. |
title_sort |
re-examination of the risk of dementia after dengue virus infection: a population-based cohort study. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2023 |
url |
https://doi.org/10.1371/journal.pntd.0011788 https://doaj.org/article/55fd547fc3624bafb5470baeee1f6d9d |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 17, Iss 12, p e0011788 (2023) |
op_relation |
https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0011788&type=printable https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0011788 https://doaj.org/article/55fd547fc3624bafb5470baeee1f6d9d |
op_doi |
https://doi.org/10.1371/journal.pntd.0011788 |
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PLOS Neglected Tropical Diseases |
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