Genetic polymorphisms in carnitine palmitoyltransferase 1A gene are associated with variation in body composition and fasting lipid traits in Yup'ik Eskimos[S]
Variants of carnitine palmitoyltransferase 1A (CPT1A), a key hepatic lipid oxidation enzyme, may influence how fatty acid oxidation contributes to obesity and metabolic outcomes. CPT1A is regulated by diet, suggesting interactions between gene variants and diet may influence outcomes. The objective...
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ftdoajarticles:oai:doaj.org/article:55ca3f543655476c96a569a60fe84c88 2023-05-15T16:07:06+02:00 Genetic polymorphisms in carnitine palmitoyltransferase 1A gene are associated with variation in body composition and fasting lipid traits in Yup'ik Eskimos[S] Dominick J. Lemas Howard W. Wiener Diane M. O'Brien Scarlett Hopkins Kimber L. Stanhope Peter J. Havel David B. Allison Jose R. Fernandez Hemant K. Tiwari Bert B. Boyer 2012-01-01T00:00:00Z https://doi.org/10.1194/jlr.P018952 https://doaj.org/article/55ca3f543655476c96a569a60fe84c88 EN eng Elsevier http://www.sciencedirect.com/science/article/pii/S0022227520408119 https://doaj.org/toc/0022-2275 0022-2275 doi:10.1194/jlr.P018952 https://doaj.org/article/55ca3f543655476c96a569a60fe84c88 Journal of Lipid Research, Vol 53, Iss 1, Pp 175-184 (2012) lipids lipids/oxidation mitochondria omega-3 fatty acids Alaska Native healthy obesity Biochemistry QD415-436 article 2012 ftdoajarticles https://doi.org/10.1194/jlr.P018952 2022-12-31T07:58:54Z Variants of carnitine palmitoyltransferase 1A (CPT1A), a key hepatic lipid oxidation enzyme, may influence how fatty acid oxidation contributes to obesity and metabolic outcomes. CPT1A is regulated by diet, suggesting interactions between gene variants and diet may influence outcomes. The objective of this study was to test the association of CPT1A variants with body composition and lipids, mediated by consumption of polyunsaturated fatty acids (PUFA). Obesity phenotypes and fasting lipids were measured in a cross-sectional sample of Yup'ik Eskimo individuals (n = 1141) from the Center of Alaska Native Health Research (CANHR) study. Twenty-eight tagging CPT1A SNPs were evaluated with outcomes of interest in regression models accounting for family structure. Several CPT1A polymorphisms were associated with HDL-cholesterol and obesity phenotypes. The P479L (rs80356779) variant was associated with all obesity-related traits and fasting HDL-cholesterol. Interestingly, the association of P479L with HDL-cholesterol was still significant after correcting for body mass index (BMI), percentage body fat (PBF), or waist circumference (WC). Our findings are consistent with the hypothesis that the L479 allele of the CPT1A P479L variant confers a selective advantage that is both cardioprotective (through increased HDL-cholesterol) and associated with reduced adiposity. Article in Journal/Newspaper eskimo* Yup'ik Alaska Directory of Open Access Journals: DOAJ Articles Journal of Lipid Research 53 1 175 184 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
lipids lipids/oxidation mitochondria omega-3 fatty acids Alaska Native healthy obesity Biochemistry QD415-436 |
spellingShingle |
lipids lipids/oxidation mitochondria omega-3 fatty acids Alaska Native healthy obesity Biochemistry QD415-436 Dominick J. Lemas Howard W. Wiener Diane M. O'Brien Scarlett Hopkins Kimber L. Stanhope Peter J. Havel David B. Allison Jose R. Fernandez Hemant K. Tiwari Bert B. Boyer Genetic polymorphisms in carnitine palmitoyltransferase 1A gene are associated with variation in body composition and fasting lipid traits in Yup'ik Eskimos[S] |
topic_facet |
lipids lipids/oxidation mitochondria omega-3 fatty acids Alaska Native healthy obesity Biochemistry QD415-436 |
description |
Variants of carnitine palmitoyltransferase 1A (CPT1A), a key hepatic lipid oxidation enzyme, may influence how fatty acid oxidation contributes to obesity and metabolic outcomes. CPT1A is regulated by diet, suggesting interactions between gene variants and diet may influence outcomes. The objective of this study was to test the association of CPT1A variants with body composition and lipids, mediated by consumption of polyunsaturated fatty acids (PUFA). Obesity phenotypes and fasting lipids were measured in a cross-sectional sample of Yup'ik Eskimo individuals (n = 1141) from the Center of Alaska Native Health Research (CANHR) study. Twenty-eight tagging CPT1A SNPs were evaluated with outcomes of interest in regression models accounting for family structure. Several CPT1A polymorphisms were associated with HDL-cholesterol and obesity phenotypes. The P479L (rs80356779) variant was associated with all obesity-related traits and fasting HDL-cholesterol. Interestingly, the association of P479L with HDL-cholesterol was still significant after correcting for body mass index (BMI), percentage body fat (PBF), or waist circumference (WC). Our findings are consistent with the hypothesis that the L479 allele of the CPT1A P479L variant confers a selective advantage that is both cardioprotective (through increased HDL-cholesterol) and associated with reduced adiposity. |
format |
Article in Journal/Newspaper |
author |
Dominick J. Lemas Howard W. Wiener Diane M. O'Brien Scarlett Hopkins Kimber L. Stanhope Peter J. Havel David B. Allison Jose R. Fernandez Hemant K. Tiwari Bert B. Boyer |
author_facet |
Dominick J. Lemas Howard W. Wiener Diane M. O'Brien Scarlett Hopkins Kimber L. Stanhope Peter J. Havel David B. Allison Jose R. Fernandez Hemant K. Tiwari Bert B. Boyer |
author_sort |
Dominick J. Lemas |
title |
Genetic polymorphisms in carnitine palmitoyltransferase 1A gene are associated with variation in body composition and fasting lipid traits in Yup'ik Eskimos[S] |
title_short |
Genetic polymorphisms in carnitine palmitoyltransferase 1A gene are associated with variation in body composition and fasting lipid traits in Yup'ik Eskimos[S] |
title_full |
Genetic polymorphisms in carnitine palmitoyltransferase 1A gene are associated with variation in body composition and fasting lipid traits in Yup'ik Eskimos[S] |
title_fullStr |
Genetic polymorphisms in carnitine palmitoyltransferase 1A gene are associated with variation in body composition and fasting lipid traits in Yup'ik Eskimos[S] |
title_full_unstemmed |
Genetic polymorphisms in carnitine palmitoyltransferase 1A gene are associated with variation in body composition and fasting lipid traits in Yup'ik Eskimos[S] |
title_sort |
genetic polymorphisms in carnitine palmitoyltransferase 1a gene are associated with variation in body composition and fasting lipid traits in yup'ik eskimos[s] |
publisher |
Elsevier |
publishDate |
2012 |
url |
https://doi.org/10.1194/jlr.P018952 https://doaj.org/article/55ca3f543655476c96a569a60fe84c88 |
genre |
eskimo* Yup'ik Alaska |
genre_facet |
eskimo* Yup'ik Alaska |
op_source |
Journal of Lipid Research, Vol 53, Iss 1, Pp 175-184 (2012) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S0022227520408119 https://doaj.org/toc/0022-2275 0022-2275 doi:10.1194/jlr.P018952 https://doaj.org/article/55ca3f543655476c96a569a60fe84c88 |
op_doi |
https://doi.org/10.1194/jlr.P018952 |
container_title |
Journal of Lipid Research |
container_volume |
53 |
container_issue |
1 |
container_start_page |
175 |
op_container_end_page |
184 |
_version_ |
1766403167385288704 |