Substandard anti-malarial drugs in Burkina Faso
Abstract Background There is concern about an increasing infiltration of markets by substandard and fake medications against life-threatening diseases in developing countries. This is particularly worrying with regard to the increasing resistance development of Plasmodium falciparum against affordab...
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ftdoajarticles:oai:doaj.org/article:55afa05972e949139fc47e90fec6068f 2023-05-15T15:14:10+02:00 Substandard anti-malarial drugs in Burkina Faso Sie Ali Hoppe-Tichy Torsten Störzinger Dominic Coulibaly Boubacar Diallo Salou Tipke Maike Müller Olaf 2008-05-01T00:00:00Z https://doi.org/10.1186/1475-2875-7-95 https://doaj.org/article/55afa05972e949139fc47e90fec6068f EN eng BMC http://www.malariajournal.com/content/7/1/95 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-7-95 1475-2875 https://doaj.org/article/55afa05972e949139fc47e90fec6068f Malaria Journal, Vol 7, Iss 1, p 95 (2008) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2008 ftdoajarticles https://doi.org/10.1186/1475-2875-7-95 2022-12-31T01:59:53Z Abstract Background There is concern about an increasing infiltration of markets by substandard and fake medications against life-threatening diseases in developing countries. This is particularly worrying with regard to the increasing resistance development of Plasmodium falciparum against affordable anti-malarial medications, which has led to a change to more expensive drugs in most endemic countries. Methods A representative sample of modern anti-malarial medications from licensed (public and private pharmacies, community health workers) and illicit (market and street vendors, shops) sources has been collected in the Nouna Health District in north-western Burkina Faso in 2006. All drugs were tested for their quality with the standard procedures of the German Pharma Health Fund-Minilab. Detected low standard drugs were re-tested with European Pharmacopoeia 2.9.1 standards for disintegration and ultraviolet-visible spectroscopy at the laboratory of the Heidelberg University for confirmation. Results Overall, 86 anti-malarial drug samples were collected, of which 77 samples have been included in the final analysis. The sample consisted of 39/77 (50%) chloroquine, 10/77 (13%) pyrimethamine-sulphadoxine, 9/77 (12%) quinine, 6/77 (8%) amodiaquine, 9/77 (12%) artesunate, and 4/77 (5%) artemether-lumefantrine. 32/77 (42%) drug samples were found to be of poor quality, of which 28 samples failed the visual inspection, nine samples had substandard concentrations of the active ingredient, four samples showed poor disintegration, and one sample contained non of the stated active ingredient. The licensed and the illicit market contributed 5/47 (10.6%) and 27/30 (90.0%) samples of substandard drugs respectively. Conclusion These findings provide further evidence for the wide-spread existence of substandard anti-malarial medications in Africa and call for strengthening of the regulatory and quality control capacity of affected countries, particularly in view of the now wider available and substantially more costly ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 7 1 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Sie Ali Hoppe-Tichy Torsten Störzinger Dominic Coulibaly Boubacar Diallo Salou Tipke Maike Müller Olaf Substandard anti-malarial drugs in Burkina Faso |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background There is concern about an increasing infiltration of markets by substandard and fake medications against life-threatening diseases in developing countries. This is particularly worrying with regard to the increasing resistance development of Plasmodium falciparum against affordable anti-malarial medications, which has led to a change to more expensive drugs in most endemic countries. Methods A representative sample of modern anti-malarial medications from licensed (public and private pharmacies, community health workers) and illicit (market and street vendors, shops) sources has been collected in the Nouna Health District in north-western Burkina Faso in 2006. All drugs were tested for their quality with the standard procedures of the German Pharma Health Fund-Minilab. Detected low standard drugs were re-tested with European Pharmacopoeia 2.9.1 standards for disintegration and ultraviolet-visible spectroscopy at the laboratory of the Heidelberg University for confirmation. Results Overall, 86 anti-malarial drug samples were collected, of which 77 samples have been included in the final analysis. The sample consisted of 39/77 (50%) chloroquine, 10/77 (13%) pyrimethamine-sulphadoxine, 9/77 (12%) quinine, 6/77 (8%) amodiaquine, 9/77 (12%) artesunate, and 4/77 (5%) artemether-lumefantrine. 32/77 (42%) drug samples were found to be of poor quality, of which 28 samples failed the visual inspection, nine samples had substandard concentrations of the active ingredient, four samples showed poor disintegration, and one sample contained non of the stated active ingredient. The licensed and the illicit market contributed 5/47 (10.6%) and 27/30 (90.0%) samples of substandard drugs respectively. Conclusion These findings provide further evidence for the wide-spread existence of substandard anti-malarial medications in Africa and call for strengthening of the regulatory and quality control capacity of affected countries, particularly in view of the now wider available and substantially more costly ... |
format |
Article in Journal/Newspaper |
author |
Sie Ali Hoppe-Tichy Torsten Störzinger Dominic Coulibaly Boubacar Diallo Salou Tipke Maike Müller Olaf |
author_facet |
Sie Ali Hoppe-Tichy Torsten Störzinger Dominic Coulibaly Boubacar Diallo Salou Tipke Maike Müller Olaf |
author_sort |
Sie Ali |
title |
Substandard anti-malarial drugs in Burkina Faso |
title_short |
Substandard anti-malarial drugs in Burkina Faso |
title_full |
Substandard anti-malarial drugs in Burkina Faso |
title_fullStr |
Substandard anti-malarial drugs in Burkina Faso |
title_full_unstemmed |
Substandard anti-malarial drugs in Burkina Faso |
title_sort |
substandard anti-malarial drugs in burkina faso |
publisher |
BMC |
publishDate |
2008 |
url |
https://doi.org/10.1186/1475-2875-7-95 https://doaj.org/article/55afa05972e949139fc47e90fec6068f |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 7, Iss 1, p 95 (2008) |
op_relation |
http://www.malariajournal.com/content/7/1/95 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-7-95 1475-2875 https://doaj.org/article/55afa05972e949139fc47e90fec6068f |
op_doi |
https://doi.org/10.1186/1475-2875-7-95 |
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Malaria Journal |
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7 |
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1 |
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1766344649357656064 |