A Case Study of Two Rodent-Borne Viruses: Not Always the Same Old Suspects
Two Old World rodents, house mice (Mus musculus) and Norway rats (Rattus norvegicus), were introduced into and established populations on every continent, save Antarctica. With their travels, they concomitantly introduced several zoonotic agents capable of causing human diseases. Two viruses—Lymphoc...
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ftdoajarticles:oai:doaj.org/article:558e692f79a1419db1cfc61d03430c01 2023-05-15T13:53:05+02:00 A Case Study of Two Rodent-Borne Viruses: Not Always the Same Old Suspects James E. Childs Sabra L. Klein Gregory E. Glass 2019-03-01T00:00:00Z https://doi.org/10.3389/fevo.2019.00035 https://doaj.org/article/558e692f79a1419db1cfc61d03430c01 EN eng Frontiers Media S.A. https://www.frontiersin.org/article/10.3389/fevo.2019.00035/full https://doaj.org/toc/2296-701X 2296-701X doi:10.3389/fevo.2019.00035 https://doaj.org/article/558e692f79a1419db1cfc61d03430c01 Frontiers in Ecology and Evolution, Vol 7 (2019) lymphocytic choriomeningitis virus Seoul virus Rattus norvegicus Mus musculus zoonotic disease Evolution QH359-425 Ecology QH540-549.5 article 2019 ftdoajarticles https://doi.org/10.3389/fevo.2019.00035 2022-12-30T22:29:25Z Two Old World rodents, house mice (Mus musculus) and Norway rats (Rattus norvegicus), were introduced into and established populations on every continent, save Antarctica. With their travels, they concomitantly introduced several zoonotic agents capable of causing human diseases. Two viruses—Lymphocytic choriomeningitis virus (LCMV; genus Arenavirus with mice) and Seoul virus (SEOV; genus Hantavirus with rats)—can cause chronic infections within their respective rodent hosts, resulting in persistent or life-long sporadic shedding of virus through secreta and excreta. Although the prevalence of infection within their wild rodent hosts can exceed 25% among mice infected with LCMV and 50% among rats infected with SEOV, acute human disease resulting from direct transmission from wild rodents is rarely reported even though both species live in close coexistence with humans. The usual “classic” zoonotic cycle of transmission from wild rodent reservoirs to humans now includes multiple unusual/unexpected routes. The largest described outbreaks of human disease caused by these viruses are linked to pet rodents. A novel reservoir host, the golden hamster, has supplanted house mice as the major source of LCMV infection, and SEOV outbreaks are linked to fancy rats kept as pets. Following LCMV, and to a lesser extent SEOV, outbreaks or infections associated with lab animals and/or cultured tissues derived from mice and hamsters have led to hundreds of cases of LCMV among laboratory workers, and SEOV has been detected among cell-cultured tissues. Additionally, LCMV is now a recognized source of severe congenital disease and is the unexpected source of severe and often fatal disease among solid organ recipients. Although the extensive usual and unusual routes of LCMV infection are exceptional there are many parallels with SEOV emergence. Article in Journal/Newspaper Antarc* Antarctica Directory of Open Access Journals: DOAJ Articles Norway Frontiers in Ecology and Evolution 7 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
lymphocytic choriomeningitis virus Seoul virus Rattus norvegicus Mus musculus zoonotic disease Evolution QH359-425 Ecology QH540-549.5 |
spellingShingle |
lymphocytic choriomeningitis virus Seoul virus Rattus norvegicus Mus musculus zoonotic disease Evolution QH359-425 Ecology QH540-549.5 James E. Childs Sabra L. Klein Gregory E. Glass A Case Study of Two Rodent-Borne Viruses: Not Always the Same Old Suspects |
topic_facet |
lymphocytic choriomeningitis virus Seoul virus Rattus norvegicus Mus musculus zoonotic disease Evolution QH359-425 Ecology QH540-549.5 |
description |
Two Old World rodents, house mice (Mus musculus) and Norway rats (Rattus norvegicus), were introduced into and established populations on every continent, save Antarctica. With their travels, they concomitantly introduced several zoonotic agents capable of causing human diseases. Two viruses—Lymphocytic choriomeningitis virus (LCMV; genus Arenavirus with mice) and Seoul virus (SEOV; genus Hantavirus with rats)—can cause chronic infections within their respective rodent hosts, resulting in persistent or life-long sporadic shedding of virus through secreta and excreta. Although the prevalence of infection within their wild rodent hosts can exceed 25% among mice infected with LCMV and 50% among rats infected with SEOV, acute human disease resulting from direct transmission from wild rodents is rarely reported even though both species live in close coexistence with humans. The usual “classic” zoonotic cycle of transmission from wild rodent reservoirs to humans now includes multiple unusual/unexpected routes. The largest described outbreaks of human disease caused by these viruses are linked to pet rodents. A novel reservoir host, the golden hamster, has supplanted house mice as the major source of LCMV infection, and SEOV outbreaks are linked to fancy rats kept as pets. Following LCMV, and to a lesser extent SEOV, outbreaks or infections associated with lab animals and/or cultured tissues derived from mice and hamsters have led to hundreds of cases of LCMV among laboratory workers, and SEOV has been detected among cell-cultured tissues. Additionally, LCMV is now a recognized source of severe congenital disease and is the unexpected source of severe and often fatal disease among solid organ recipients. Although the extensive usual and unusual routes of LCMV infection are exceptional there are many parallels with SEOV emergence. |
format |
Article in Journal/Newspaper |
author |
James E. Childs Sabra L. Klein Gregory E. Glass |
author_facet |
James E. Childs Sabra L. Klein Gregory E. Glass |
author_sort |
James E. Childs |
title |
A Case Study of Two Rodent-Borne Viruses: Not Always the Same Old Suspects |
title_short |
A Case Study of Two Rodent-Borne Viruses: Not Always the Same Old Suspects |
title_full |
A Case Study of Two Rodent-Borne Viruses: Not Always the Same Old Suspects |
title_fullStr |
A Case Study of Two Rodent-Borne Viruses: Not Always the Same Old Suspects |
title_full_unstemmed |
A Case Study of Two Rodent-Borne Viruses: Not Always the Same Old Suspects |
title_sort |
case study of two rodent-borne viruses: not always the same old suspects |
publisher |
Frontiers Media S.A. |
publishDate |
2019 |
url |
https://doi.org/10.3389/fevo.2019.00035 https://doaj.org/article/558e692f79a1419db1cfc61d03430c01 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
Frontiers in Ecology and Evolution, Vol 7 (2019) |
op_relation |
https://www.frontiersin.org/article/10.3389/fevo.2019.00035/full https://doaj.org/toc/2296-701X 2296-701X doi:10.3389/fevo.2019.00035 https://doaj.org/article/558e692f79a1419db1cfc61d03430c01 |
op_doi |
https://doi.org/10.3389/fevo.2019.00035 |
container_title |
Frontiers in Ecology and Evolution |
container_volume |
7 |
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1766258036361396224 |