Chronic hepatitis C virus infections in Brazilian patients: association with genotypes, clinical parameters and response to long term alpha interferon therapy
The present study assessed the clinical significance of hepatitis C virus (HCV) genotypes and their influence on response to long term recombinant-interferon-alpha (r-IFN- a ) therapy in Brazilian patients. One hundred and thirty samples from patients previously genotyped for the HCV and with histol...
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ftdoajarticles:oai:doaj.org/article:558220bc66e542478674d7414eaa556a 2024-09-09T19:27:59+00:00 Chronic hepatitis C virus infections in Brazilian patients: association with genotypes, clinical parameters and response to long term alpha interferon therapy Leda BASSIT Luiz C. DA SILVA Gabriela RIBEIRO-DOS-SANTOS Geert MAERTENS Flair J. CARRILHO Luis E. P. FONSECA Venâncio A. F. ALVES Luis C.C. GAYOTTO Analice N. PEREIRA Kioko TAKEI Dalton CHAMONE Amadeo SÁEZ-ALQUÉZAR 1999-05-01T00:00:00Z https://doaj.org/article/558220bc66e542478674d7414eaa556a EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651999000300010&tlng=en https://doaj.org/toc/1678-9946 1678-9946 https://doaj.org/article/558220bc66e542478674d7414eaa556a Revista do Instituto de Medicina Tropical de São Paulo, Vol 41, Iss 3, Pp 183-189 (1999) Brazilian patients Genotypes HCV IFN therapy Sustained response Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 1999 ftdoajarticles 2024-08-05T17:49:31Z The present study assessed the clinical significance of hepatitis C virus (HCV) genotypes and their influence on response to long term recombinant-interferon-alpha (r-IFN- a ) therapy in Brazilian patients. One hundred and thirty samples from patients previously genotyped for the HCV and with histologically confirmed chronic hepatitis C (CH-C) were evaluated for clinical and epidemiological parameters (sex, age, time of HCV infection and transmission routes). No difference in disease activity, sex, age or mode and time of transmission were seen among patients infected with HCV types 1, 2 or 3. One hundred and thirteen of them were treated with 3 million units of r-IFN- a , 3 times a week for 12 months. Initial response (IR) was significantly better in patients with genotype 2 (100%) and 3 (46%) infections than in patients with genotype 1 (29%) (p < 0.005). Among subtypes, difference in IR was observed between 1b and 2 (p < 0.005), and between 1b and 3a (p < 0.05). Sustained response (SR) was observed in 12% for (sub)type 1a, 13% for 1b, 19% for 3a, and 40% for type 2; significant differences were found between 1b and 2 (p < 0.001), and between 1b and 3a (p < 0.05). Moreover, presence of cirrhosis was significantly associated with non response and response with relapse (p < 0.05). In conclusion, non-1 HCV genotype and lack of histological diagnosis of cirrhosis were the only baseline features associated with sustained response to treatment. These data indicate that HCV genotyping may have prognostic relevance in the responsiveness to r-IFN- a therapy in Brazilian patients with chronic HCV infection, as seen in other reports worldwide. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Brazilian patients Genotypes HCV IFN therapy Sustained response Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Brazilian patients Genotypes HCV IFN therapy Sustained response Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Leda BASSIT Luiz C. DA SILVA Gabriela RIBEIRO-DOS-SANTOS Geert MAERTENS Flair J. CARRILHO Luis E. P. FONSECA Venâncio A. F. ALVES Luis C.C. GAYOTTO Analice N. PEREIRA Kioko TAKEI Dalton CHAMONE Amadeo SÁEZ-ALQUÉZAR Chronic hepatitis C virus infections in Brazilian patients: association with genotypes, clinical parameters and response to long term alpha interferon therapy |
topic_facet |
Brazilian patients Genotypes HCV IFN therapy Sustained response Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
The present study assessed the clinical significance of hepatitis C virus (HCV) genotypes and their influence on response to long term recombinant-interferon-alpha (r-IFN- a ) therapy in Brazilian patients. One hundred and thirty samples from patients previously genotyped for the HCV and with histologically confirmed chronic hepatitis C (CH-C) were evaluated for clinical and epidemiological parameters (sex, age, time of HCV infection and transmission routes). No difference in disease activity, sex, age or mode and time of transmission were seen among patients infected with HCV types 1, 2 or 3. One hundred and thirteen of them were treated with 3 million units of r-IFN- a , 3 times a week for 12 months. Initial response (IR) was significantly better in patients with genotype 2 (100%) and 3 (46%) infections than in patients with genotype 1 (29%) (p < 0.005). Among subtypes, difference in IR was observed between 1b and 2 (p < 0.005), and between 1b and 3a (p < 0.05). Sustained response (SR) was observed in 12% for (sub)type 1a, 13% for 1b, 19% for 3a, and 40% for type 2; significant differences were found between 1b and 2 (p < 0.001), and between 1b and 3a (p < 0.05). Moreover, presence of cirrhosis was significantly associated with non response and response with relapse (p < 0.05). In conclusion, non-1 HCV genotype and lack of histological diagnosis of cirrhosis were the only baseline features associated with sustained response to treatment. These data indicate that HCV genotyping may have prognostic relevance in the responsiveness to r-IFN- a therapy in Brazilian patients with chronic HCV infection, as seen in other reports worldwide. |
format |
Article in Journal/Newspaper |
author |
Leda BASSIT Luiz C. DA SILVA Gabriela RIBEIRO-DOS-SANTOS Geert MAERTENS Flair J. CARRILHO Luis E. P. FONSECA Venâncio A. F. ALVES Luis C.C. GAYOTTO Analice N. PEREIRA Kioko TAKEI Dalton CHAMONE Amadeo SÁEZ-ALQUÉZAR |
author_facet |
Leda BASSIT Luiz C. DA SILVA Gabriela RIBEIRO-DOS-SANTOS Geert MAERTENS Flair J. CARRILHO Luis E. P. FONSECA Venâncio A. F. ALVES Luis C.C. GAYOTTO Analice N. PEREIRA Kioko TAKEI Dalton CHAMONE Amadeo SÁEZ-ALQUÉZAR |
author_sort |
Leda BASSIT |
title |
Chronic hepatitis C virus infections in Brazilian patients: association with genotypes, clinical parameters and response to long term alpha interferon therapy |
title_short |
Chronic hepatitis C virus infections in Brazilian patients: association with genotypes, clinical parameters and response to long term alpha interferon therapy |
title_full |
Chronic hepatitis C virus infections in Brazilian patients: association with genotypes, clinical parameters and response to long term alpha interferon therapy |
title_fullStr |
Chronic hepatitis C virus infections in Brazilian patients: association with genotypes, clinical parameters and response to long term alpha interferon therapy |
title_full_unstemmed |
Chronic hepatitis C virus infections in Brazilian patients: association with genotypes, clinical parameters and response to long term alpha interferon therapy |
title_sort |
chronic hepatitis c virus infections in brazilian patients: association with genotypes, clinical parameters and response to long term alpha interferon therapy |
publisher |
Universidade de São Paulo (USP) |
publishDate |
1999 |
url |
https://doaj.org/article/558220bc66e542478674d7414eaa556a |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 41, Iss 3, Pp 183-189 (1999) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651999000300010&tlng=en https://doaj.org/toc/1678-9946 1678-9946 https://doaj.org/article/558220bc66e542478674d7414eaa556a |
_version_ |
1809897297987764224 |